ESPE2023 Poster Category 1 Pituitary, Neuroendocrinology and Puberty (73 abstracts)
The Difference in Newly diagnosed Precocious Puberty Before and During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis
Nam Nhat Nguyen 1 , Tri Dang Do 2,3 , Hieu Hong Truong 4 , Anh Nam Mai 5,6 , Hsien-Yu Fan 7,8 & Yang-Ching Chen 9,10,11,8
1College of Medicine, Taipei Medical University, Taipei, Taiwan. 2Department of Pediatrics, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. 3Department of Nephrology and Endocrinology, Children’s Hospital, Ho Chi Minh City, Vietnam. 4Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, USA. 5Faculty of Medicine, College of Medicine and Pharmacy, Duy Tan University, Da Nang, Vietnam. 6Institute for Research and Training in Medicine, Biology and Pharmacy, Duy Tan University, Da Nang, Vietnam. 7Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan. 8Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 9School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan. 10Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan. 11Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan
Keywords: precocious puberty, COVID-19
Background: Studies have reported an increase in precocious puberty (PP) cases during the COVID-19 pandemic, but there is inconsistency in the findings. Various influencing factors have been proposed to explain this surge. The present study aimed to investigate the PP trend following the pandemic, examine potential influencing factors, and investigate the dose-response relationship between time points and the risk of PP.
Methods: We searched for four databases until Feb 20, 2023, to seek articles reporting various indicators relevant to the incidence of PP before and during the pandemic. We included participants visiting pediatric clinics for suspected PP for the first time. The number of events and total observations were extracted. Meta-analyses were conducted to compare the risk of PP and the differences in other factors between the two periods. Subgroup, meta-regression, and sensitivity analyses were pre-planned.
Main findings: COVID-19 was associated with an increasing Incidence of PP among children referred for PP (OR 1.96, 95% CI 1.56–2.47, I2 = 54%, p < 0.01). Sensitivity analysis showed that our findings were robust. Entering the COVID-19 pandemic, children had earlier PP onset and earlier clinic visits, but similar to Tanner’s stage at first presentation. BMI SDS of children pre- and during COVID-19 was no different. The PP incidence since the COVID-19 outbreak has increased more rapidly compared to the pre-pandemic period.
Conclusions: Our results indicated that there was a dose-dependent increase in the PP incidence and an acceleration in the timing of puberty following the COVID-19 pandemic. Many environmental factors could contribute to this phenomenon.
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