ESPE2023 Poster Category 2 Thyroid (13 abstracts)
Hypothyroidism without elevation of thyroid-sttmulating hormone associated with oxcarbazepine use in children and adolescents
Insung Kim 1 , JiHoon Hwang 1 , Juyoung Sung 1 , Min-Sun Kim 1 , Hyunju Park 2 , Jung Heo 2 , Min-ji Kim 3 , Jee-Hun Lee 1 , Dong-Kyu Jin 1 , Tae Hyuk Kim 2 , Jae Hoon Chung 2 , Sung Yoon Cho 1 & Sung Wook Kim 2
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of. 2Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of. 3Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of
Introduction: Hypothyroidism without elevation of thyroid-stimulating hormone level during oxcarbazepine use in children and adolescent. There have been studies on the association of oxcarbazepine, which is used as an anticonvulsant, with hypothyroidism, but studies in children and adolescents have been limited. The authors aimed to determine the effects of long-term oxcarbazepine on thyroid function in children and adolescents.
Methods: This study was a retrospective cohort study of pediatric patients who were treated with oxcarbazepine for the first time in management epilepsy between 2003 and 2020. Changes in serum triiodothyronine (T3), thyroxine (T4), free thyroxine (or fT4), and thyroid-stimulating hormone (TSH) were evaluated during treatment. Thyroid hormone levels were followed up for 5 years after starting the drug.
Results: Changes in TSH levels during the treatment period were insignificant. However, thyroid hormone levels showed a significant decrease for 2 years after the start of treatment and were maintained thereafter. About 6% of the patients observed during the study required levothyroxine administration.
Conclusion: A significant decrease in thyroid function was observed when using oxcarbazepine in children and adolescents. Therefore, regular evaluation of thyroid function is necessary when using oxcarbazepine. Since hypothyroidism without TSH changes is shown, this should be borne in mind when performing the test.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more