ESPE Abstracts

Objective: determination of changes in metabolic status and osteoprotegerin (OPG) concentrations in obese children.

Methods: We examined 220 children in the University Hospital (Minsk) from 2022 to 2023 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of OPG, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) - 160 patients (90 boys(B)/70 girls(G)) (BMI more than 99th percentile for sex and age) (BMI 34.14±2.64 kg/m², age 13.37±2.22 years); group 2 - 70 patients (B/G=35/35) with alimentary obesity (AO) (BMI-95-99th percentile for sex and age) (BMI 27.16±2.36 kg/m², age 13.13±2.17 years). The control group (C) consisted of 60 patients (B/G=30/30) with normal body weight (BMI 19.66±2.34 kg/m², age 13.42±2.31 years).

Results: In boys and girls with obesity higher concentrations of insulin were detected relative to the control group (АО (G 17.35 (9.92–19.30) µU/ml; B 18.17 (8.41–22.00) µU/ml) and МО (G 23.16 (12.66–28.54) µU/ml; B 25.79 (12.76–29.40) µU/ml); С (G 8.35 (5.95–11.50) µU/ml; B 9.23 (7.90-11.21) µU/ml) (G U_АО-С=528.0; р<0.001; U_МО-С=776.0; р<0.001; B U_АО-С=453.5; р<0.001; U_МО-С=691.0; р<0.001)). Insulin resistance index level (HOMA-IR) in patients with АО (G 3.26 (1.97–3.84); B 3.69 (1.55–4.37)) and МО (G 4.54 (2.37–6.12); B 4.21 (2.54–5.36)) was higher than in the control (G 1.60 (0.99–2.18); B 1.89 (1.53–2.30)) (G U_АО-С=219.0; р<0.001; U_МО-С=354.0; р<0.001; B U_АО-С=1150.5; р=0.001; U_МО-С=592.5; р<0.001). In boys with obesity higher concentrations of OPG were detected relative to the control group (АO 250.89±22.17 ng/ml vs 189.91±11.32 ng/ml (P=0.04), MO 222.22±21.14 ng/ml vs 189.91±11.32 ng/ml (P=0.03)).

Conclusion: Changes in metabolic status were registered in obese patients: an increase in insulin, OPG levels compared with children with normal body weight.