ESPE2023 Poster Category 2 Fetal, Neonatal Endocrinology and Metabolism (6 abstracts)
Foetal exposures to endocrine-disrupting chemicals. INMA-ASTURIAS COHORT. SPAIN.
Ana Cristina Rodríguez-Dehli 1,2,3 , Ana Fernández-Somoano 2,3 , Isolina Riaño Galán 4,2,3 & Adonina Tardon 2,3
1Hospital Universitario San Agustín, Avilés, Spain. 2Universidad de Oviedo y CIBERESP, Oviedo, Spain. 3Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. 4Hospital Universitario Central de Asturias, Oviedo, Spain
Background: Endocrine-disrupting chemicals (EDCs) are serious and urgent threats to public health, due to the potentially serious adverse effects of EDCs on endocrine processes during susceptible periods of human development.
Objective: To evaluate the levels endocrine disruptors at gestation.
Material and methods: A pilot study. Data were obtained from 30 pregnant mothers recruited in Asturias between 2004-2007 and their children from of the Environment and Childhood [INfancia y Medio Ambiente] (INMA) Project, a population-based birth cohort study. Maternal endocrine disruptors urinary levels (phthalates, parabens, benzophenone and bisphenol A) were analyzed at 12 weeks of gestation.
Results: The urinary levels of the following endocrine disruptors are analyzed at 12 weeks of gestation: Mono(carboxy-isononyl), Mono(carboxy-isooctyl) phthalates, Mono-2-ethyl-5-carboxypentyl phthalate, Mono-2-ethyl-5-hydroxyhexyl phthalate, Mono-2-ethyl-5-oxohexyl phthalate, Mono-2-ethylhexyl phthalate, Mono-3-carboxypropyl phthalate, Mono-isobutyl phthalate, Mono-n-butyl phthalate, Monobenzyl phthalate, Monoethyl phthalate, 2 5-dichlorophenol, Ethyl Paraben, Methyl Paraben, Propyl Paraben, benzophenone-3 and bisphenol A, showing the results in table 1.
| N | Mean | D. T. | P25 | Median | P75 | Range | |
| Mono(carboxy-isononyl) phthalates | 30 | 9.51 | 13.71 | 2.30 | 3.65 | 9.10 | 1.30-52.90 |
| Mono(carboxy-isooctyl) phthalates | 30 | 8.64 | 10.53 | 3.10 | 5.20 | 9.90 | 1.00- 45.50 |
| Mono-2-ethyl-5-carboxypentyl phthalate | 30 | 87.64 | 132.49 | 22.60 | 36.90 | 97.40 | 14.20- 609.00 |
| Mono-2-ethyl-5-hydroxyhexyl phthalate | 30 | 52.13 | 94.52 | 10.50 | 19.10 | 63.20 | 7.80- 419.00 |
| Mono-2-ethyl-5-oxohexyl phthalate | 30 | 46.67 | 83.15 | 10.90 | 18.55 | 51.90 | 4.30- 367.00 |
| Mono-2-ethylhexyl phthalate | 27 | 14.48 | 27.48 | 2.10 | 5.50 | 12.50 | 1.30- 129.00 |
| Mono-3-carboxypropyl phthalate | 30 | 6.04 | 14.54 | 1.10 | 1.80 | 3.40 | 0.50- 66.30 |
| Mono-isobutyl phthalate | 30 | 64.00 | 63.44 | 18.60 | 47.10 | 68.90 | 10.80- 273.00 |
| Mono-n-butyl phthalate | 30 | 219.22 | 947.12 | 20.50 | 34.10 | 62.80 | 9.70- 5230.00 |
| Monobenzyl phthalate | 30 | 26.21 | 41.70 | 8.10 | 14.50 | 26.90 | 2.40- 228.00 |
| Monoethyl phthalate | 30 | 506.07 | 685.18 | 120.00 | 291.50 | 449.00 | 30.90- 3270.00 |
| 2 5-dichlorophenol | 30 | 40.98 | 70.95 | 9.50 | 15.15 | 27.00 | 1.50- 341.00 |
| Ethyl Paraben | 27 | 22.04 | 34.24 | 3.90 | 8.80 | 20.90 | 2.10- 151.00 |
| Methyl Paraben | 30 | 455.27 | 1244.24 | 34.50 | 114.40 | 304.00 | 1.50- 6780.00 |
| Propyl Paraben | 28 | 86.94 | 197.25 | 3.55 | 13.00 | 47.50 | 0.40- 947.00 |
| benzophenone-3 | 27 | 21.85 | 41.05 | 2.30 | 5.40 | 26.60 | 0.40- 180.00 |
| bisphenol A | 30 | 6.80 | 11.51 | 2.10 | 3.30 | 5.90 | 0.50- 59.90 |
Conclusions: All the pregnant mothers were exposed to all the disruptors analyzed, with the potential risk to the health of their offspring.
Article tools
My recent searches
My recently viewed abstracts
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more