ESPE Abstracts

Objective: Observe in children born SGA the relationship that the different variables have in the evolution towards metabolic syndrome, adrenarche and/or early/advanced pubarche or short stature and treatment with GH.

Material and Methods:A retrospective observational study analyzing in SGA children at birth (n=103) and who are currently between 7-9 years of age, variables such as: sex; “Catch UP” at 2 years old and the type; GH treatment; presence of adrenarche and/or early/advanced pubarche; presence of metabolic syndrome through BMI and other measures such as BP and blood levels of LDL/HDL, insulin, and HbA1. These last values could not be analyzed in all patients, only in those who had performed a measurement or analysis for some other reason (n=1, n=9, n=1, n=1 respectively). Statistical study SPSS 11.0. Study X squared, paired samples. Significance P<0.05.

Results: Of the 103 cases collected, 61 are boys and 42 girls. 89 of them (86.4%) performed the catch up before the age of 2, of which 28 (27.2%) were classified as fast catch up. 14 did not catch up (13.6%). At the current age, only one patient has received GH treatment, none has presented signs of adrenarche and/or precocious/advanced puberty and 7 of them (6.8%) have evolved to obesity. Associating the different variables, a statistically significant relationship has been seen between a catch up before 2 years of age and obesity (P<0.05). No significant results have been seen between gender and the other variables (P>0.05). It has not been possible to draw conclusions about adrenarche and/or early/advanced pubarche since no case has been registered. Nor could it be seen the relationship between the absence of Catch up before 2 years and the need for GH (P>0.05).

Conclusions: Our findings determine that the correct coding of SGA children at birth, a close follow-up of growth and preventing a rapid catch up could prevent the subsequent development of obesity and, therefore, future Sd. metabolic. Probably this result would be even more significant if there were measurements of the rest of the parameters that complete the Sd. metabolic. In this work we have studied children who are currently between 7-9 years old. It would be interesting to conclude the follow-up of this same group and re-analyze them at the end of puberty, in order to obtain more significant results about the relationship between SGA children and puberty itself.