ESPE Abstracts

Objective: To analyze the correlation between glucose metabolism disorder and bone turnover markers in obese adolescents.

Methods: From June 2022 to June 2023, 50 obese adolescents in West China Second Hospital of Sichuan University were taken as the research group, and 50 adolescents with normal weight who received health examination at the same time were taken as the control group. The general data, glucose metabolism indexes and bone turnover markers were compared between the two groups, and the correlation between glucose metabolism indexes and bone turnover markers in obese group was analyzed by canonical correlation. Obesity group was divided into hyperglycemia group and normal blood sugar group according to blood sugar, and the correlation between bone turnover markers and the risk of hyperglycemia was analyzed by Kendall correlation.

Results: Body mass index (BMI), fasting blood glucose (FBG), insulin resistance index (HOMA-IR), insulin-like growth factor 1(IGF-1), insulin-like growth factor binding protein 3(IGFBP-3), total type 1 collagen amino-terminal peptide (P1NP) and B- collagen degradation product (B-CTX) in obese group were all higher than those in control group (P <0.05）. The correlation between the first pair (r =0.968) and the second pair (r =0.452) was significant (P <0.05), which was determined by insulin and HOMA-IR in glucose metabolism indexes, P1NP and B-CTX in bone turnover markers, and HOMA-IR and P1NP and P1NP in typical variables. HOMA-IR, FBG, IGF-BP-3, IGF-1, P1NP and B-CTX in hyperglycemia group were higher than those in normal blood sugar group (P <0.05). Kendall analysis showed that the risk of hyperglycemia was correlated with P1NP(r =0.715), B-CTX(r =0.530) and N-MID(r =0.566) (P <0.05).

Conclusion: Obese adolescents are accompanied by disorder of glucose metabolism, which can affect bone turnover markers, especially P1NP and B-CTX.