ESPE Abstracts

Introduction: Autoimmune thyroid disease and type 1 diabetes (T1DM) often cooccur, particularly among children. This study aim ed to explore the relationship between type 1 diabetes and autoimmune thyroiditis, examining influencing factors such as gender, age, and duration of diabetes. Additionally, we assessed the glycemic control of all patients involved in the study.

Keywords: diabetes- children- auto immune thyroid disease

Material and Methods: This is a retrospective, descriptive study including 435 children hospitalized in the endocrinology-diabetology-nutrition department for the management of type I diabetes. All patients underwent a clinical examination and a biological work-up. The statistical analysis was performed with SPSS-version-21-software

Results: We involved 435 children diagnosed with T1DM. Five percent of patients tested for anti TPO antibodies were positive at the time of T1DM diagnosis. Among these patients, 18.3 % developed positive anti – TPO antibodies with an average of 6.07±3.15 years after the diagnosis of T1DM. All patients were in euthyroidism state, with a mean age of 11.3 years (4 -16) and a mean diabetes duration of 5.21±3.57 years (0-9). After 5±3.3 years (range 0- 9 years), evolution towards subclinical hypothyroidism due to Hashimoto thyroiditis was observed in (87%) of cases, while 13% developed clinical hypoythyroidism. The mean value of HBA1C was at 9.2 % ±1.5% in patients with thyroiditis compared to the average of 7.9 % ± 0.7 % in those without thyroiditis.

Conclusion: Thyroid autoimmunity is frequently present among T1DM patients, can be associated with increased age, long diabetes duration, and can unbalance the glycemic control of T1DM patients.