hrp0098p1-307 | Late Breaking 2 | ESPE2024

The man in the LOOP: Ramadan fast in Type 1 diabetic patients with a Closed Loop automated insulin delivery system

Abraham Schuldenfrei Yonatan , Sharaf Al-Hayek Narmeen , Cohen Amitay , Eliyahu Mendelsohn Espen , Abu Libdeh Abedelsalam , Lavi Eran , Zangen David

Background: Fasting during Ramadan, starting daily before sunrise and ending at sunset, with traditional rich meals at "Sohoor" (pre-dawn) and "Fotoor" (evening break of fast). is common among Muslims from 8 years of age. Recent use of the closed loop automated insulin delivery system (CLAIDS) including insulin pump and glucose sensor has become staple treatment of type 1 diabetes (T1D) patients and reported to safely manage glucose fluctua...

hrp0089p2-p229 | GH & IGFs P2 | ESPE2018

Area under the Curve of Growth Hormone, An Additional Tool in Assessing Stimulation Test Results

Yeshayahu Yonatan , Frizinsky Shirly

Introduction: Growth hormone (GH) deficiency is diagnosed through the combination of clinical observation and low GH upon stimulation, in two separate stimulation tests. Normal response is considered as a single rise of GH above the local cutoff point which is used, and differs between countries and range between 7–10 mcg/L. The aim of our study was to assess whether a calculation of area under the curve (AUC) of GH can be used as an additional tool in the diagnosis of GH...

hrp0084p2-390 | Fat | ESPE2015

Programming of Rat Behaviours and the Stress Response by Duration of the Infancy Stage

Crispel Yonatan , Katz Oren , Hochberg Ze'ev

Background: The age at weaning programs life history adaptively. Shorter infancy resulted in longer/thinner animals with a reproductive-strategic shift to earlier physical and sexual development (BMC Med, 2013).Hypotheses: The length of infancy impacts also the stress-response and has behavioural consequences.Method: Sprague-Dawley pups (generation F1), which usually are weaned at age 21 days, were weaned by cross-fostering at age ...

hrp0098p2-213 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Saliva sex-hormones as an alternative method for assessment of pubertal status

Vinker-Shuster Michal , Ofek-Geva Ella , Fortus David , Yeshayahu Yonatan

Background: Pubertal assessment is based on patient history, physical examination, bone age, blood tests, and in some cases, endocrine “stimulation tests”. Sex hormones are present in saliva and may serve as a cost-effective, simple, and painless alternative for invasive blood or stimulation tests performed at day care units. Previous studies showed correlation between saliva-and-blood levels of sex hormones; However, it is not in routine clinical ...

hrp0098p1-125 | Diabetes and Insulin 3 | ESPE2024

RISING TREND OF TYPE 2 DIABETES FOLLOWING COVID-19 PANDEMIC IN PAEDIATRIC AGE GROUP

Paulose Abraham , Kurian Akhila

Background: The alarming increase in the prevalence of obesity in children and adolescents following COVID-19 pandemic has given rise to an upward trend in Type 2 Diabetes.Aims/Objectives: To determine the prevalence of newly diagnosed Type 2 Diabetes in children and adolescents from the year 2018 to 2022.Methods: A hospital based retrospective study was conducted in the Paediatric...

hrp0098p2-116 | Fat, Metabolism and Obesity | ESPE2024

Prevalence of Central Obesity Among Adolescent School Children in Rural Kerala, South India.

Paulose Abraham , P Raghupriya

Background: Central obesity among adolescents has been on the rise globally and there is ample evidence that to suggest that central obesity is a strong predictor of cardiovascular disease and Type 2 Diabetes.Aims/Objectives: To determine the prevalence of Central Obesity among adolescent school children aged 14-18 years in rural Kerala.Methods: A descriptive cross-sectional, schoo...

hrp0095p2-159 | Growth and Syndromes | ESPE2022

SHOX haploinsufficiency among patients with idiopathic short stature

Kedar Tal , Marek-Yagel Dina , Gruber Noah , Mazor-Aronovitch Kineret , Pinhas-Hamiel Orit , Yeshayahu Yonatan

Shox gene deficiency which causes short stature is a known indication for treatment with growth hormone. The prevalence of shox deficiency among children with idiopathic short stature has a high variability in different studies and ranges between 1.5-17%. We aimed to determine the incidence of SHOX haploinsufficiency in our region and to assess the genotype-phenotype relation which may help with setting criteria in the decision to which patients should we offer this genetic te...

hrp0092rfc5.5 | Thyroid | ESPE2019

A Novel Mutation in the Thyroglobulin Gene Leading to Neonatal Goiter and Congenital Hypothyroidism in an Eritrean Infant

Stern Eve , Kassif Eran , Schoenmakers Nadia , Gruber Noah , Pinhas-Hamiel Orit , Yeshayahu Yonatan

Background: Congenital hypothyroidism is a common condition with reported incidence between 1/2000 – 1/4000 live births. In approximately 85% of cases this is sporadic due to a structural abnormality of the thyroid gland. Approximately 15% of cases are hereditary and secondary to thyroid dyshormonogenesis. Most of these are due to mutations in one of the genes involved in iodine transport or organification, mutations in the thyroglobulin gene or d...

hrp0086p2-p56 | Adrenal P2 | ESPE2016

The Effect of Anti-TNF on the Metabolism of Adrenal Hormones; A Steroid Metabolomic Approach

Keinan Ariel , Hartmann Michaela F. , Butbul Yonatan , Wudy Stefan A. , Tiosano Dov

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease seen in children. The systemic features of JIA are mediated by cytokine products of an activated immune system. Recent studies showed that the median level of urine cortisol in active JIA patients is significantly lower than remission period and control groups.Objective and hypotheses: One of the najor drugs in JIA is TNFα blocker (Enbrel). The aim of the study was ...

hrp0098p2-293 | Thyroid | ESPE2024

Prevalence and Predictor Factors of Transient Congenital Hypothyroidism in Resource-limited Setting

Paulose Abraham , Sreelal Shraddha , KK Diwakar

Background: In recent years, different studies have shown an increasing trend in the prevalence of transient congenital hypothyroidism, varying from 20 to 89%.Aims/Objectives: 1. To determine the prevalence of transient hypothyroidism (TCH) among children diagnosed with congenital hypothyroidism (CH) on newborn screening (NBS). 2. To identify the predictive factors for distinguishing between transient and permanent hypot...