hrp0095p2-265 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Gynecomastia and Short Height;45,X[2]/ 46,X, +mar[28] karyotype

Derya Buluş Ayşe , Dünya Betül , Yaşartekin Yüksel , Cevdet Ceylan Ahmet

Introduction: Physiological pubertal gynecomastia is common in adolescents aged 13-14 years. Most physiological pubertal gynecomastia regresses spontaneously within 1-2 years. In studies: If it lasts more than 2 years, if prepubertal has started, endocrine evaluation is recommended. Sex differentiation disorders or genital abnormalities such as increased aromatase activity, adrenal/testicular neoplasia, partial androgen insensitivity syndrome and Klinefelter s...

hrp0095p1-387 | Thyroid | ESPE2022

Pediatric Graves Disease (PGD): presentation, treatment and follow up. A single center Argentine perspective

Rothenfusser Anna , Eugenia Masnata Maria , Suco Valle Sofia , Eugenia Rodriguez Maria , Bergada Ignacio , Papendieck Patricia , Elena Chiesa Ana

Introduction: PGD is characterized by hyperthyroidism and antibodies against the TSH receptor (TSHRAB). Reported annual incidence is 4,58/100,000.Objective: To describe an Argentinean cohort with PGD followed between 2006 and 2020 at the Ricardo Gutierrez Children’s Hospital.Material and Methods: Retrospective study of 69 patients, who were treated initially with antithyroid ...

hrp0082p2-d1-533 | Puberty and Neuroendocrinology | ESPE2014

Polycystic Ovarian Syndrome in Adolescents: Metabolic Profile at Diagnosis, During and After Treatment with Oral Contraceptive

Arcari Andrea , Gryngarten Mirta , Ballerini Maria Gabriela , Freire Analia , Rodriguez Maria Eugenia , Ropelato Maria Gabriela , Bergada Ignacio , Escobar Maria Eugenia

Background: Obesity and unfavorable metabolic profile (insulin resistance and/or dyslipidemia) are frequently observed in Polycystic Ovarian Syndrome in Adolescents (PCOS) girls regardless of weight.Objective and hypotheses: To evaluate clinical features and metabolic profile in PCOS adolescents, before, during and after Oral Contraceptive (OC) treatment.Method: We performed a retrospective study on 51 girls with PCOS diagnosed acc...

hrp0092p1-72 | GH and IGFs | ESPE2019

Diagnostic Value of Random Serum Growth Hormone (GH), IGF-I and IGFBP-3 Concentrations for the Diagnosis of Growth Hormone Deficiency (GHD) in Patients Below One Year of Life

Ballerini María Gabriela , Braslavsky Débora , Freire Analía Verónica , Keselman Ana , Rodríguez María Eugenia , Altube Mercedes , Scaglia Paula Alejandra , Bergadá Ignacio , Ropelato María Gabriela

GHD diagnosis in neonates and infants is a challenge owing to the fact that GH pharmacological stimulation tests (GHST) are not approved at this age. In a retrospective study, we found that a random GH<6.5 µg/L confirmed GHD diagnosis in neonates with clinical suspicion of GHD with high diagnostic accuracy (1). The accuracy of GH and its surrogates of action have not been set for infants with current standardized immunoassays.Objective</...

hrp0084p3-996 | Gonads | ESPE2015

Endocrine Disruptor and Premature Puberty, is There Any Association?

Riano-Galan Isolina , Menendez Adrian Estrada , Lopez Ana Perez , Fuente Mar Coto , Moran Margot , Rodriguez-Dehli Cristina

Background: Endocrine disruptors (ED) can alter endocrine function. ED have become a part of everyday life and are found among phytoestrogens, active ingredients in pharmaceuticals, and additives or contaminants in food, personal care products, cosmetics, plastics and textiles.Objective: To describe cases of children with signs of early puberty who are exposed to ED.Method: Observational study of patients affected of premature pube...

hrp0092lb-7 | Late Breaking Posters | ESPE2019

Long-Term Evaluation of Ovarian Function and Follicular Reserve in Patients with Malignant Diseases Treated with Chemotherapy in Prepubertal or Pubertal Age

Josefina Arcari Andrea , Verónica Freire Analía , Paula Grinspon Romina , Bedecarrás Patricia , Eugenia Escobar María , Gabriela Ropelato María , Bergadá Ignacio , Rey Rodolfo , Graciela Gryngarten Mirta

The survival rate of young patients with cancer has greatly improved in the last decades, in part due to the introduction of new therapeutic agents and protocols.Chemotherapy may be associated with risk of ovarian dysfunction, permanent or transient amenorrhea, symptoms of ovarian insufficiency and infertility.It has been suggested that prepubertal ovary is less susceptible to deleterious effect of chemotherapy.<p class="abstex...

hrp0095p1-214 | Adrenals and HPA Axis | ESPE2022

Development and validation of simultaneous quantification of urinary catecholamines and free metanephrines by UHPLC-MS/MS method

Eugenia Rodriguez Maria , Gabriela Ballerini Maria , Ambao Veronica , Vieites Ana , Sanso Gabriela , Rey Rodolfo , Bergada Ignacio , Gabriela Ropelato Maria

Background: Neuroendocrine tumors from adrenal and extra-adrenal chromaffin cells are characterized by overproduction of catecholamines (CA), leading to the increase of urinary O-methylated metabolites (uO-Met) excretion, reliable biomarkers for the initial screening, diagnosis and monitoring of patients with pheochromocytoma and paragangliomas (PPGLs).Objective: To develop and validate a UHPLC-MS/MS method for the simul...

hrp0089p1-p147 | GH &amp; IGFs P1 | ESPE2018

Serum IGFBP-2 Concentration in Neonates with Potential Diagnosis of Growth Hormone Deficiency (GHD)

Gabriela Ballerini Maria , Braslavsky Debora , Keselman Ana , Eugenia Rodriguez Maria , Gotta Gabriela , Gabriela Ropelato Maria , Bergada Ignacio

In a retrospective study (1), we found that a GH<6.5 μg/L, IGF-I-WHO87/518 <30 μg/L and IGFBP-3<0.8 μg/mL confirmed GHD diagnosis with high diagnostic accuracy in neonates with clinical suspicion of GHD. GH and insulin negatively regulate IGFBP-2, and it was proposed to reflect GH status in the diagnostic work-out of GHD in childhood and adults. The accuracy of IGFBP-2 has not been set for neonates.Objective: To prospectively v...

hrp0094p1-108 | Adrenal B | ESPE2021

Circadian rhythm of cortisol in saliva in obese children with clinical signs of hypercortisolism

Gabriela Ballerini Maria , Arcari Andrea Josefina , Brenzoni Luciana , Veronica Freire Analia , Eugenia Rodriguez Maria , Amaro Andrea , Bravlavsky Debora , Maggioni Irina , Keselman Ana , Bergada Ignacio , Gabriela Ropelato Maria ,

Due to the increase in prevalence of childhood obesity, more obese children are referred to the endocrinologist for the hypothalamus-hypophysis-adrenal axis assessment. The circadian rhythm (CR) of cortisol in saliva (SAF) may constitute a non-invasive, first line test to exclude hypercortisolism on obese children.Aim: To evaluate possible disturbances of CR of SAF in obese children with clinical signs of hypercortisolism.<p class="a...

hrp0098p1-184 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Assessment of hypogonadotropic hypogonadism using a gonadotropic-gonadal stimulation test with subcutaneous Triptorelin: preliminary results.

Freire Analía , Arcari Andrea , Gabriela Ballerini María , Grinspon Romina , Castro Sebastian , Eugenia Rodriguez María , Gryngarten Mirta , Keselman Ana , Braslavsky Débora , Bergadá Ignacio , Rey Rodolfo , Gabriela Ropelato María

Introduction: Comprehensive evaluation of the gonadotropic axis, including pituitary and gonadal assessment, using a diagnostic test with aGnRH (Triptorelin) could be useful in the differential diagnosis between hypogonadotropic hypogonadism (HH) and self-limited delayed puberty (SLDP) or amenorrhea of unknown cause.Objective: To assess the performance of the Triptorelin test for the diagnosis of HH and to compare it wit...