hrp0098p1-201 | Thyroid 2 | ESPE2024

Potential Role of Selected miRNAs in the Pathogenesis of Autoimmune Thyroid Diseases in Children and Adolescents

Sawicka Beata , Sulewska Anetta , Kulczyńska- Przybik Agnieszka , Bossowski Filip , Dulewicz Maciej , Borysewicz-Sańczyk Hanna , Mroczko Barbara , Niklinski Jacek , Bossowski Artur

Background: Many epigenetic factors, including microRNAs, are involved in the process of changing gene expression. MiRNAs are small non-coding RNA molecules that regulate gene translation by silencing or degrading target mRNAs. They are recognized as novel diagnostic and prognostic biomarkers for many diseases. Patients with autoimmune thyroid diseases are more likely to develop nodules in the thyroid tissue, and Hashimoto's thyroiditis and Graves’ ...

hrp0084p1-123 | Thyroid | ESPE2015

Th17 Cells in Children with Graves’ Disease During Methimazole Treatment

Klatka Maria , Grywalska Ewelina , Rolinski Jacek

Background: Graves’ disease (GD) is the most common cause of hyperthyroidism in the pediatric population. T helper 17 (Th17) IL-17A+CD3+CD4+ cells represent a novel subset of T helper cells that play an active role in inflammatory and autoimmune diseases. Although methimazole (MMI) lowers the levels of thyroid autoantibodies, little is still known about its influence on cell-mediated immune response. The role of Th17 cells in GD pathogenesis remains uncertain and the impa...

hrp0086rfc14.7 | Growth : Mechanisms | ESPE2016

GH Influences Plasma Fasting Adropin Concentration in Patients with Turner Syndrome

Wikiera Beata , Krawczyk Magdalena , Noczynska Anna , Daroszewski Jacek

Background: Increased adiposity and insulin resistance are conditions frequently observed nowadays. Many hormones are involved in the pathogenesis of the condition but therapeutic options we can offer to the patients are still scant. Each newly discovered peptide give us hope. Adropin (Ad) is a newly discovered metabolic hormone involved in energy homeostasis. This homeostasis is frequently disturbed in patient with Turner Syndrome (TS). Patient with Turner syndrome are unique...

hrp0086p1-p907 | Thyroid P1 | ESPE2016

Dysregulation of the Immune System in Children with Graves Disease – the Role of NK and NKT-Like Cells

Klatka Maria , Polak Agnieszka , Grywalska Ewelina , Kollataj Witold , Rolinski Jacek

Background: Almost all cases of hyperthyroidism in children result from Graves’ disease (GD). Recent studies have confirmed a significant role of T cells in the development of autoimmune diseases. However, the interactions between NKT-like cells and NK cells in GD are still poorly understood.Objective and hypotheses: The aim of the study was to assess the frequencies of peripheral blood T, NK and NKT-like cells in children with GD.<p class="abst...

hrp0082p1-d2-244 | Thyroid (1) | ESPE2014

Treatment of Graves’ Disease with Methimazole in Children Alters the Proliferation of Treg Cells and T Lymphocytes

Klatka Maria , Grywalska Ewelina , Wasiak Magdalena , Rolinski Jacek

Background: Graves’ disease (GD) is almost always the cause of hyperthyroidism in children. Studies carried out for recent years confirm an important role of T regulatory cells (Tregs) in the development of autoimmune diseases. However, the interactions between T-cell response and Treg proliferation in GD is still poorly understood.Objective and hypotheses: The aim of this research was the assessment of the in vitro proliferation of Treg ce...

hrp0089p1-p263 | Thyroid P1 | ESPE2018

Expression of ZnT8 Transporter in Thyroid Tissues from Patients with Immune and Non-Immune Thyroid Diseases

Bossowski Artur , Reszec Joanna , Polnik Dariusz , Gasowska Marta , Niklinska Wieslawa

Introduction: Zinc homeostasis is regulated by ZnT and Zip zinc transporters. Zinc transporter 8 (ZnT8) is localized in insulin containing secretory granule membrane and transports zinc from the cytosol into the vesicles. ZnT8 was identified on peripheral lymphocytes, in subcutaneous adipose tissue, in a pancreatic β-cells and extra-pancreatic endocrine glands including pituitary, adrenal and thyroid. Autoantibodies to the ZnT8 are detected in the majority of type 1 diabe...

hrp0092rfc12.2 | Growth and Syndromes (to include Turner syndrome) | ESPE2019

Treatment with Growth Hormone Increases Klotho Concentration in Patients with Turner Syndrome

Wikiera Beata , Seifert Monika , Nocon-Bohusz Julita , Noczynska Anna , Daroszewski Jacek

Background: Short stature, increased adiposity and insulin resistance are conditions frequently observed in patients with Turner syndrome (TS). Many hormones are involved in the pathogenesis of the condition but therapeutic options we can offer to the patients are still scant. Each newly discovered peptide give us hope. Klotho play a very important role in the regulation of the human body metabolism and was not investigated in patients with TS so far.<p cl...

hrp0089p1-p148 | GH &amp; IGFs P1 | ESPE2018

GH Treatment Causes an Increase in Klotho Concentration in Children with Growth Hormone Deficiency

Wikiera Beata , Seifert Monika , Nocon-Bohusz Julita , Noczynska Anna , Daroszewski Jacek

Introduction: Klotho is a protein which may serve as a regulator of GH secretion. Growth hormone deficiency is diagnosed in children with growth restriction when GH secretion in two GH stimulation tests do not exceed the level of 10 ng/ml.Aim: The objective of the study was to investigate Klotho and FGF23 in children with growth hormone deficiency (GHD) and their responce to the treatment with recombinant human growth hormone (rHGH).<p class="abstext...

hrp0082p1-d1-63 | Diabetes | ESPE2014

Th17 Cells in Children with New Onset Type 1 Diabetes

Piekarski Robert , Ben-Skowronek Iwona , Bojarska-Junak Agnieszka , Tabarkiewicz Jacek , Szewczyk Leszek

Background: A recent data indicates a complex mechanism of β-cell destruction in type 1 diabetes in which despite Th1/Th2 bias different other populations of immune cells like Th17 with specific IL17A secretion with proinflammatory action will mediate β cells autoreactivity. In humans, the relevance of Th17 cells in new onset T1DM is still controversial.Objective and hypotheses: The aim of our study was to evaluate circulating Th17 in children ...

hrp0084p1-86 | Growth Hormone | ESPE2015

The Growth Hormone Treatment Results in the Increase of Irisin Concentration in Plasma

Wikiera Beata , Pukajlo Katarzyna , Laczmanski Lukasz , Sloka Natalia , Basiak Aleksander , Noczynska Anna , Bolanowski Marek , Daroszewski Jacek

Background: Brown adipose tissue metabolism is of remarkable pathophysiological interest, because it could be a target for therapies for obesity and metabolic syndrome. Irisin (Ir), recently identified adipomyokine is essential in a white-to-brown fatty tissue transdifferentiation, and mediates some of the positive influences on metabolic disorders through increase of energy expenditure. The exact regulation of Ir secretion and action is unknown but positive associations of ci...