hrp0097p2-47 | GH and IGFs | ESPE2023

The Interaction between Growth Hormone (GH) -Insulin-like Growth factor 1 (IGF1) axis and Immune Systems in Infants and Children During undernutrition: Newly Discovered Pathological mechanisms.

Soliman Ashraf , Alaaraj Nada , Rogol Alan , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Soliman Nada

Accumulating evidence indicates various interactions between the GH-IGF1 axis and the immune system in infants and children during undernutrition.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on the link between the GH-IGF1 axis and the immune system in infants and children during malnutrition. We reviewed 22 studies (2007-2...

hrp0097p2-48 | GH and IGFs | ESPE2023

The Value of using IGF1/Growth Hormone Peak Ratio in Children with Idiopathic Short Stature

Soliman Ashraf , Alyafei Fawzia , Elsideeq Sohair , Hamed Noor , Ahmed Shayma , Alaaraj Nada

Introduction: Stimulated GH peak values have been shown to correlate well with nocturnal GH peak values and with nocturnal mean GH values. In addition, the expression level of serum IGF-1 in ISS has been shown to be significantly lower than that in normal children despite their normal GH peak response to provocation.Objectives: To investigate the value of using the IGF1/GH peak ratio in the anthropometric assessment of c...

hrp0097p2-136 | GH and IGFs | ESPE2023

Human milk insulin-like growth factors and Cyclic glycine-proline (cGP) concentrations in relation to infantile and childhood growth.

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Nada

Introduction: Insulin-like growth factor (IGF)-1, IGF binding proteins (IGFBPs) and regulatory metabolites, including cyclic Glycine-Proline (cGP), have a possible role in modifying infant growth trajectories through their effects on linear growth, and body composition. There is no consensus on how maternal BMI affects breast milk IGF1 level.Aim: We reviewed the recent literature about human milk (IGF)-1, and cGP concent...

hrp0097p2-161 | GH and IGFs | ESPE2023

Maternal Factors affecting Human milk insulin-like growth factor (IGF) (HMIGF1) level.

Soliman Ashraf , Hamed Noor , Alaaraj Nada , Alyafei Fawzia , Ahmed Shayma , Adel Ashraf

Introduction: Accumulating evidence indicates various but significant effects of human milk IGF1 (HMIGF1) on infantile and childhood linear growth and weight gain. Studies on maternal factors affecting the level of HMIGF1 need to be clarified.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on maternal factors ...

hrp0097p2-5 | Growth and Syndromes | ESPE2023

Variations in body composition, IGF1 and Cyclic glycine-proline (cGP) concentrations in breastfed vs formula fed infants during infancy period.

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Nada , Shaat Mona

Introduction: Breastfeeding is one of the most effective preventive measures of childhood obesity and many other chronic diseases. The effect of breastfeeding vs formula feeding in changing infant`s body composition remains unclear.Aim and Methods: The objective of this review is to update and summarize the recent literature (Pubmed, Google scholar, Scopus and Research gate in the past 10 years) on studies investig...

hrp0097p2-194 | Growth and Syndromes | ESPE2023

Impact of Undernutrition and Short Stature on The Quality of Life (QOL) in Children and adolescents with Beta thalassemia Major (BTM)

Soliman Ashraf , Ahmed Shayma , Soliman Nada , Elalaily Rania , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Itani Maya

Introduction: Quality of life (QoL), comprises physical, psychological, environmental, and social aspects, is an index designed to measure the burden of chronic diseases and evaluate the treatment outcome. Thalassemia major (BTM) is a chronic disease in children that harms children QoL by interrupting physical function, emotional function, social function, and school function. ObjectivesAim: This study aims to identify t...

hrp0097p2-1 | Multisystem Endocrine Disorders | ESPE2023

Prevalence of Malnutrition and Underweight in Children and Adolescents with Beta-Thalassemia Major (BTM)

Soliman Ashraf , Yassin Mohamed , Alyafei Fawzia , Ahmed Shayma , Alaaraj Nada , Soliman Nada

Introduction: Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition affects the growth, efficacy of treatments, and quality of life in children suffering from BTM.Objective: To evaluate the prevalence of malnutrition (BMI < 3rd centile for age and sex) or BMISDS < -2 in 10 Mediterranean and Middle east countries and the USA in the past 20 years.  <p c...

hrp0097p2-87 | Multisystem Endocrine Disorders | ESPE2023

Undernutrition, abnormal body composition, and impaired linear growth in children and adolescents with Beta-Thalassemia Major: possible contributing factors

Soliman Ashraf , Ahmed Shayma , Alaaraj Nada , Elalaily Rania , Alyafei Fawzia , Hamed Noor , Soliman Nada

Introduction:Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition negatively affects their growth, efficacy of treatments, and quality of life.Objective: To evaluate the nutritional status and linear growth in 10 countries in the past 20 years.Methods: We performed an electronic search in PubMed, Google Scholar, and Web of Scie...

hrp0098t1 | Top 20 Posters | ESPE2024

Genetic and Nutritional Influences on Growth: A Case of PAPPA2-Related Growth Disorder in a Pediatric Patient.

Elsiddig Sohair , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Alyafei Fawzia , Soliman Ashraf

Background: Growth disorders in children often present a multifactorial challenge involving genetics, nutrition, and endocrine function. This case report focuses on a young girl with growth retardation linked to a homozygous pathogenic variant in the PAPPA2 gene, encoding pregnancy-associated plasma protein-A2 (PAPP-A2), a key regulator in the insulin-like growth factor 1 (IGF-I) axis.Case Presentation: A 5-year-old girl...

hrp0098p1-49 | GH and IGFs 1 | ESPE2024

Correlations Between Nutritional Interventions, Growth Dynamics, and IGF-1 Levels in Pediatric Populations: A Comprehensive Analysis

Soliman Ashraf , Sabt Amal , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Alyafei Fawzia

Introduction: The complex interplay between nutritional status, body mass index (BMI), and insulin-like growth factor-1 (IGF-1) is pivotal in understanding pediatric growth. Our study investigates these relationships to enhance growth outcomes in children.Objective: We aimed to evaluate the effects of nutritional interventions on BMI, height growth velocity, and IGF-1 levels in 125 underweight children aged 2-10, who und...