hrp0082p2-d1-588 | Thyroid | ESPE2014

Investigation of Autoimmune Diseases Accompanying Hashimoto’s Thyroiditis in Children and Adolescents and Evaluation of Cardiac Signs

Bas Veysel Nijat , Agladioglu Sebahat Yilmaz , Ozgur Senem , Karademir Selmin , Aycan Zehra

Objective: In the present study, it was aimed to investigate the concomitance of additional cardiac problems, mainly mitral valve prolapse, in adolescents and pediatric patients with Hashimoto’s thyroiditis, by screening autoimmune markers.Methods: Euthyroid 57 patients, who applied to the Pediatric Endocrinology clinic at our institution with marked symptoms of hypothyroidism at the time of diagnosis, and were diagnosed and treated for Hashimoto&#1...

hrp0084p3-665 | Bone | ESPE2015

Vitamin D Status in Children in the Western Part of Turkey

Ozhan Bayram , Evrengul Havva , Agladioglu Sebahat Yilmaz , Yasar Sukru Umit , Demir Suleyman

Background: An optimal vitamin D status is important for the growth and development of bones in children and adolescents. The prevalence of vitamin D deficiency is still high, even in low-latitude and industrialized countries, and vitamin D deficiency in childhood is reemerging as major public health issue.Objectives: To determine the frequencies of 25-hydroxyvitamin D (25(OH)D) deficiency and insufficiency in children and adolescents.<p class="abste...

hrp0082p1-d2-79 | Diabetes (1) | ESPE2014

Sequence Analysis of 11 Known Causative Genes in Clinically Diagnosed Children as Maturity Onset Diabetes of Youth by Next Generation Sequencing

Agladioglu Sebahat Yilmaz , Aycan Zehra , Cetinkaya Semra , Bas Veysel Nijat , Onder Asan , Kendirci Havva Nur Peltek , Dogan Haldun , Ceylaner Serdar

Introduction: Maturity-onset diabetes of the youth (MODY), is a genetically and clinically heterogeneous group of diseases in the pancreatic β–cell that impair insulin secreation. It mostly caused by heterozygous mutations in one of 11 different genes associated with β–cell function. The aim of this study is detection of the distribution of both known and novel point mutations of these genes in Turkish population.Pati...

hrp0084p3-1061 | Hypo | ESPE2015

Clinical Characteristics and Molecular Analysis of Turkish Patients with Congenital Hyperinsulinism: a Single-Centre Experience with 15 Cases

Agladioglu Sebahat Yilmaz , Aycan Zehra , Cetinkaya Semra , Erdeve Senay Savas , Sagsak Elif , Keskin Meliksah , Kurnaz Erdal , Flanagan Sarah E , Ellard Sian , Hussain Khalid

Objective: Congenital hyperinsulinism (CHI) is the most common cause of hypoglycaemia in children. Early identification and management is crucial to prevent irreversible brain damage. CHI has a heterogeneous clinical presentation, histology and molecular biology. We aim to discuss the clinical characteristics and genotype–phenotype correlations of Turkish CHI patients from a single centre.Design and methods: A total of 15 patients with CHI were recr...

hrp0084p3-1218 | Thyroid | ESPE2015

Effects of Subclinically Hypothyroidism on Haemorheological Parameters in Paediatric Population

Balci Yasemin Isik , Agladioglu Sebahat Yilmaz , Agladioglu Kadir , Toprak Emine Kilic , Erkek Ozgen Kilic , Ozhan Bayram , Polat Aziz , Kucukatay Melek Bor

Objective: Subclinical hypothyroidism (SH) prevalence in the paediatric population is reported between 1.7 and 9.5%. Results of the adult studies on SH showed that long term SH had negative effects on atherosclerosis, dyslipidaemia, insulin resistance and cognitive functions. The decision about treatment of SH in paediatric patients is still a matter of debate. None of the consensus statements published about the management of SH addressed the issue of SH in the paediatric pop...

hrp0084p1-144 | Miscelleaneous | ESPE2015

Primary Adrenal Insufficiency in Children without Congenital Adrenal Hyperplasia: Molecular and Clinical Characterisation of a Nationwide Cohort

Guran Tulay , Buonocore Federica , Saka Nurcin , Ozbek Mehmet Nuri , Aycan Zehra , Bereket Abdullah , Bas Firdevs , Darcan Sukran , Bideci Aysun , Turan Serap , Guven Ayla , Tarim Omer , Agladioglu Sebahat Yilmaz , Atay Zeynep , Ozen Samim , Demir Korcan , Akinci Aysehan , Aydin Banu Kucukemre , Buyukinan Muammer , Yuksel Bilgin , Yildiz Metin , Akcay Teoman , Kara Cengiz , Ozgen Tolga , Catli Gonul , Isik Emregul , Bolu Semih , Ozhan Bayram , Gurbuz Fatih , Ucar Ahmet , Demirbilek Huseyin , Abali Zehra Yavas , Doger Esra , Eren Erdal , Berberoglu Merih , Hacihamdioglu Bulent , Achermann John C.

Background: Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that requires accurate diagnosis and urgent treatment. Congenital adrenal hyperplasia is the most common cause of PAI in children. Non-CAH causes of PAI are relatively rare. Although several molecular causes have been found, it is emerging that considerable overlap in the clinical and biochemical features of these conditions exists.Objective and hypotheses: We inv...