hrp0084p3-904 | Fat | ESPE2015

Generalized Idiopathic Benign Acanthosis Nigricans in Childhood

Isguven Pinar , Ermis Bahri

Background: Acanthosis nigricans (AN) is a dermatosis characterised by velvety hyperpigmentation, skin thickening, and papillomatosis. AN is generally associated with endocrine disorders (diabetes mellitus, obesity, polycystic ovary syndrome), drugs, and malignancy. In rare cases, it can be unrelated to any systemic disease. Here, we report on a 5-year-old boy from Turkey with diffuse, progressive skin hyperpigmentation.Case report: He was born in a non-...

hrp0082p2-d2-598 | Thyroid (1) | ESPE2014

An Unusual Presentation of Acquired Hypothyroidism: the Van Wyk–Grumbach Syndrome

Isguven Pinar , Uluc Nefise , Kosecik Mustafa , Karacan Mehmet , Ermis Bahri

Background: Van Wyk–Grumbach syndrome (VWGS) is characterized by breast development, uterine bleeding and multi-cystic ovaries in the presence of long-lasting primary hypothyroidism.Objective and hypotheses: The pathophysiology of VWGS involves a complex mechanism, which is at least partly mediated by the direct action of TSH and FSH receptors.Method: We present a girl with Down syndrome having typical feature...