hrp0097p1-205 | Adrenals and HPA Axis | ESPE2023

Effects of hyperandrogenism on psychological perception and quality of life in patients with non-classical congenital adrenal hyperplasia

Karamfilova Teodora , Galcheva Sonya , Bocheva Yana , Iotova Violeta

Background: Non-classical congenital adrenal hyperplasia (NCCAH) is a hyperandrogenic disorder affecting negatively the psychological health and the quality of life (QoL) of patients.Aim: To evaluate the psychological health and QoL in female NCCAH patients in comparison to female age-matched healthy controls.Participants and Methods: A total of sixty-eight females, aged 10-27 year...

hrp0097p2-183 | Diabetes and Insulin | ESPE2023

New onset diabetes – frequency of DKA and positive islet autoantibodies at Varna’s diabetes center

Bazdarska Yuliya , Stefanov Hari , Bocheva Yana , Iotova Violeta

Background and Aims: Initial presentation of type 1 diabetes (T1D) is associated with different level of diabetic ketoacidosis (DKA). Four pancreatic islet cell autoantibodies (Abs) mostly associate with T1D - glutamic acid decarboxylase antibodies (anti-GAD65), tyrosine phosphatase antibodies (IA 2-Ab), insulin autoantibody (anti-IAA) and zinc transporter 8 antibodyAim: To evaluate the prevalence of DKA, the frequency o...

hrp0095p1-217 | Adrenals and HPA Axis | ESPE2022

Precocious Pubarche in Girls - A Clinical Sign for Underlying Hyperandrogenic Disease

Galcheva Sonya , Karamfilova Teodora , Yordanova Nikolinka , Bocheva Yana , Mladenov Vilhelm , Iotova Violeta

Background: Precocious pubarche (PP), defined as the development of pubic hair before 8 years of age in females could be the first sign of a hyperandrogenic condition.Aim: The purpose of the study was to analyze the etiology of premature androgenization of girls with a history for PP and to evaluate their clinical, laboratory and ovarian ultrasound profile.Material and methods: A t...

hrp0095p1-409 | Adrenals and HPA Axis | ESPE2022

Clinical, laboratory and body composition profile of young female patients with non-classic congenital adrenal hyperplasia

Karamfilova Teodora , Galcheva Sonya , Bocheva Yana , Ivanova Darina , Bazdarska Yuliya , Iotova Violeta

Background: Non-classic congenital adrenal hyperplasia (NCCAH) is a genetic disorder characterized by hyperandrogenism associated with potential metabolic alterations and changes in body composition and bone mineral parameters.Aim: The purpose of this pilot study was to evaluate the clinical and biochemical characteristics in association with bone mineral parameters and body composition in female patients diagnosed with ...

hrp0092p1-350 | Fat, Metabolism and Obesity (2) | ESPE2019

Metabolic Risk in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

Belcheva Milena , Iotova Violeta , Usheva Nataliya , Bocheva Yana , Popova Ralitsa , Pancheva Ruzha , Hristozova Hristina , Kaleva Valeriya

The aim of this study is to evaluate the modifiable factors of metabolic risk among survivors of childhood acute lymphoblastic leukemia (ALL) treated at a single center in comparison with healthy controls.Forty-seven long-term survivors, aged 9-32 years were compared to 35 age- and sex-matched controls. Anthropometric features and laboratory findings were assessed. The body composition was measured by Dual-energy X-ray absorptiometry (DEXA). The physical...

hrp0092p2-149 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Clinical and Genetic Characteristics of Patients with Hyperinsulinaemic Hypoglycaemia Diagnosed and Treated at a Tertiary Endocrine Center, a part of the ENDO-ERN

Galcheva Sonya , Iotova Violeta , Ellard Sian , Chuperkova Jivka , Bazdarska Yuliya , Bocheva Yana , Flanagan Sarah E.

Background: Hyperinsulinaemic hypoglycaemia (HH) is a clinically and genetically heterogeneous group of disorders characterized by persistent hypoglycaemia due to inappropriate insulin secretion from the pancreatic β-cell.Aim: The objective was to analyze the demographic, clinical and genetic characteristics of patients with HH, diagnosed and/or treated at a tertiary endocrine center, part of the European referen...

hrp0092p2-174 | GH and IGFs | ESPE2019

Empirical Change of Practice in Treatment of Growth Hormone Deficient Patients in Order to Improve 1st Year Height Outcome

Rankova Kamelia , Galcheva Sonya , Mladenov Vilchelm , Boyadzhiev Veselin , Bocheva Yana , Yordanova Nikolinka , Bazdarska Yulia , Iotova Violeta

Growth hormone (GH) has been used for the treatment of short stature due to GH deficiency (GHD) for over 60 years. Height velocity (HV) in the first year of therapy is well studied and its crucial importance for growth outcome in subsequent years is confirmed.Objectives: The aim of this study is to assess the responsiveness to GH treatment in GHD patients of a newly established treatment center before and after change in starting GH dose...

hrp0086p2-p505 | Fat Metabolism and Obesity P2 | ESPE2016

Irisin and Abdominal Obesity in Preschool Age

Lateva Mina , Popova Ralitsa , Bocheva Yana , Galcheva Sonya , Chervenkov Trifon , Iotova Violeta

Background: Since its discovery in 2012 the ‘browining’ adipokine irisin is known to lead to increased thermogenesis and energy expenditure. Studies in children are scarce, with results similar to most studies in adults.Objective and hypotheses: To establish a link between total and abdominal fat mass, physical activity and irisin in preschool age.Method: Height, weight and waist circumference (WC) of 40 healthy pre-puber...

hrp0086p2-p853 | Syndromes: Mechanisms and Management P2 | ESPE2016

A 3-year-old Boy with Growth Hormone Deficiency and Clinical Features of Ritscher–Schinzel Syndrome

Galcheva Sonya , Iotova Violeta , Bocheva Yana , Stoeva Iva , Tincheva Radka , Georgiev Radoslav , Marinov Lachezar

Ritscher-Schinzel (cranio-cerebello-cardiac, 3C) syndrome is a very rare recently delineated disorder with Dandy-Walker malformation, congenital heart defects and dysmorphic craniofacial features; however, the full spectrum of this disorder has not been determined.Objective and hypotheses: To present a patient with short stature and growth hormone (GH) deficiency as a part of the clinical manifestations of Ritscher-Schinzel syndrome.<p class="abstext...

hrp0097p1-579 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Comparison between clinical, metabolic and hormonal parameters in adolescent girls with hyperandrogenism and healthy controls

Mladenov Vilhelm , Galcheva Sonya , Karamfilova Teodora , Bocheva Yana , Ivanova Darina , Iotova Violeta

Background: Polycystic ovary syndrome (PCOS) and non-classical congenital adrenal hyperplasia (NCCAH) are the most common hyperandrogenic disorders in adolescent girls. Though their etiology and pathogenesis differ, there is a significant overlap between physiological, clinical and hormonal findings and physiological phenomena. Adult patients with PCOS have increased prevalence of obesity, metabolic disturbances, increased cardiovascular risk, risk of impaired...