hrp0084p3-852 | Fat | ESPE2015

Comparison of the Insulin Resistance Index HOMA-IR between Obese and Normal Children

Rocheleau Ghislain , Dewitte Aude , Bonnefond Amelie , Weill Jacques

Background: Adult obese subjects are susceptible to an excess of cardiovascular events due to insulin resistance through the metabolic syndrome or hyperinsulinism itself. These deleterious factors go on and amplify from childhood into adulthood. To the best of our knowledge no comparison of insulin resistance indices has been performed between obese and normal children.Objectives: The main objective of this study is to compare the insulin sensitivity ind...

hrp0089p1-p049 | Diabetes & Insulin P1 | ESPE2018

Life Changing Decisions due to Etiological Genetic Diagnosis in Families of Children with Maturity Onset Diabetes of the Young (MODY)

Bril Gherta , Vaxillaire Martine , Gruber Noah , Mazor-Aronovitch Kineret , Ben-Ami Michal , Ben-David Rachel Frumkin , Yeshayahu Yonathan , Sand Olivier , Bonnefond Amelie , Froguel Philippe , Pinhas-Hamiel Orit

Background: Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of disorders characterized by pancreatic beta-cell dysfunction, and usually referred to monogenic forms of diabetes mellitus to distinguish them from the more common type 1 (T1D) or type 2 diabetes (T2D). Fourteen different MODY genetic subtypes have been identified so far. Making a definite diagnosis is very challenging because of overlapping clinical phenotypes between diabetes subtypes. Neverth...