hrp0086p2-p585 | Perinatal Endocrinology P2 | ESPE2016

Change Level of TRAb in Newborn Leads to Thyroid Dysfunction – Case Report

Sawicka Beata , Borysewicz- Sanczyk Hanna , Bossowski Artur

Maternal new-diagnosed Graves’ disease is quite rare thyroid dysfunction with an estimated incidence of 0.4–1% of all pregnancies, but only 1–5% of newborns delivered to mothers with Graves’ disease develop overt clinical signs and symptoms of hyperthyroidism. Neonatal hyperthyroidism almost always is transient and results from the transplacental passage of maternal thyrotropin (TSH) receptor stimulating antibodies. Neonates born to mothers with Graves&#146...

hrp0082p1-d2-23 | Autoimmune Endocrine Disease | ESPE2014

Analysis of Zinc Transporter ZnT8 Autoantibodies in Children and Adolescents with Autoimmune Thyroid Diseases

Bossowski Artur , Borysewicz-Sanczyk Hanna , Glowinska-Olszewska Barbara , Sawicka Beata , Bossowska Anna , Michalak Justyna , Furmaniak Jadwiga

Background: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. Moreover it was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. ZnT8 autoantibodies (ZnT8 Ab) next to glutamic acid decarboxylase antibodies (GAD Ab), insulin autoantibodies (IAA), and islet antigen-2 antibodies (IA-2 Ab) have been described as markers of autoimmune process ...

hrp0082p2-d2-465 | Growth (1) | ESPE2014

Assessment of Omentin-1, Vaspin, and Visfatin Levels in Pediatric Patients with GH Deficiency

Sawicka Beata , Borysewicz-Sanczyk Hanna , Zasim Aneta , Jakubowska Ewa , Bossowski Artur

Introduction: GH deficiency (GHD) is a disease, in which the pituitary gland does not produce enough GH. GHD has a variety of different negative effects at different ages; e.g. it can result short stature and increased adiposity. Excessive intra-abdominal fat is associated with an increased risk of cardiovascular disease. In recent years new adipokines such as:omentin-1, vaspin, and visfatin have been described. Omentin-1 is decreased in obesity in contrast to increased vaspin...

hrp0082p3-d3-948 | Puberty and Neuroendocrinology (1) | ESPE2014

Hypothalamic Hamartoma as a Cause of Central Precocious Puberty in 4.5-Year-Old Girl: Case Report

Jakubowska Ewa , Sawicka Beata , Borysewicz-Sanczyk Hanna , Zasim Aneta , Bossowski Artur

Background: Hamartoma is a benign, focal malformation, which is composed of tissue elements normally found at that site which are arranged chaotically within the mass. It may occur in many different parts of the body and often is undetected. Hypothalamic hamartoma, unlike most such growths, is symptomatic. It may cause gelastic seisures, visual problems, rage disorders and early onset of puberty.Objective and hypotheses: A 4.5-year-old girl was hospitali...

hrp0084p1-164 | Miscelleaneous | ESPE2015

Practical Application of Elastography in the Diagnosis of Thyroid Nodules in Children

Borysewicz-Sanczyk Hanna , Sawicka Beata , Dzieciol Janusz , Drzewek Katarzyna , Oleksinska Magdalena , Noiszewska Klaudyna , Bossowski Artur

Background: Elastography is non-invasive ultrasound method of imaging based on estimation of mechanical properties (elasticity) of the tissue. Recent data has shown its ability to differentiate benign from malignant tumours. Decreased flexibility in comparison to around tissue is characteristic for malignant tissues, like most thyroid carcinoma (except follicular thyroid carcinoma). Analysis of the image gives the result presented as a ROI1/ROI2 index.Ob...

hrp0084p3-1247 | Programming & Misc. | ESPE2015

The Association between Selected Endocrinopathies and Central Arterial Pressure in Children and Adolescents

Noiszewska Klaudyna , Krentowska Anna , Skoneczny Anna , Mazur Agnieszka , Borysewicz-Sanczyk Hanna , Bossowski Artur

Background: Many endocrinopathies are associated with cardiovascular abnormalities. Central blood pressure (CAP), reflecting the condition of blood vessels, may be useful in monitoring of patients with endocrinopathies.Objective and hypotheses: To evaluate parameters of CAP in patients with selected endocrinopathies.Method: The study group comprised 122 patients (58 girls and 64 boys) with endocrinopathies: GH deficiency before GH ...

hrp0097p2-101 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Change in timbre of voice as one of the signs of hyperandrogenism in a 11-year-old girl- a case report

Sawicka Beata , Szarras-Czapnik Maria , Borysewicz-Sanczyk Hanna , Michalak Justyna , Stozek Karolina , Bossowski Artur

Background: Partial gonadal dysgenesis with a 46,XY karyotype (46,XY PGD) is a disorder of sex development (DSD) associated with abnormal development of the gonads. It is characterized by abnormally developed external genitalia with or without Mullerian structures. The degree of abnormality varies from a female phenotype with clitoral hyperplasia to a male phenotype with isolated hypospadias. The incidence is unknown. In 20-30% of patients, gonadoblastoma or i...

hrp0092p1-148 | Thyroid | ESPE2019

Activating mutation M453V in receptor TSHR as a cause familial hyperthyroidism

Sawicka Beata , Stephenson Alexandra , Borysewicz- Sanczyk Hanna , Michalak Justyna , Stozek Karolina , Tanja Diana , Kahaly George , Paschke Ralf , Bossowski Artur

The most common hyperthyroidism in children is Graves' disease. The other rare cause of hyperthyroidism is activating mutation in receptor TSHR in thyroid gland.We would like to introduce a case of familial hyperthyroidism with a novel mutation M453V in the TSHR in three membersActually 11-year-old boy is a patient in outpatient clinic for first days after birth. During gestation his mother was treated with thyreostatic drugs b...

hrp0082p1-d1-232 | Thyroid | ESPE2014

Chosen Polimorphisms in FoxP3 Gene in Children and Adolescents with Autoimmune Thyroid Diseases

Bossowski Artur , Borysewicz-Sanczyk Hanna , Wawrusiewicz-Kurylonek Natalia , Szalecki Mieczyslaw , Wikiera Beata , Barg Ewa , Mysliwiec Malgorzata , Kucharska Anna , Bossowska Anna , Goscik Joanna , Ziora Katarzyna , Gorska Maria , Kretowski Adam

Background: Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune diseases especially autoimmune thyroid diseases (AITDs).Objective and hypotheses: The aim of our study was to estimate the association of three polymorphism of FOXP3...

hrp0094p2-475 | Thyroid | ESPE2021

Case study of 13- year-old boy suffering from papillary thyroid cancer in stage pT3aN1bMX

Bossowski Artur , Borysewicz-Sanczyk Hanna , Stożek Karolina , Dzięcioł Janusz , Czarniecka Agnieszka , Handkiewicz-Junak Daria , Jarząb Barbara

Papillary cancer represents majority of thyroid malignancies in children. However prognosis remains very successful. In recent years, we use elastography, except biopsy and standard ultrasonography in thyroid lesions diagnostic. We present a case of a male patient at the age of 13 years, with a history of ADHD and school phobia who was referred to Endocrinology Outpatient Clinic due to partial empty sella syndrome. Family history of endocrinological disorders was negative. Ph...