hrp0095p2-150 | GH and IGFs | ESPE2022

Alterations in stem cell populations during rIgF-1 (Increlex) therapy in patients with SPIGF1D

Bossowski Artur , Grubczak Kamil , Stożek Karolina , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin

Pathway involving insulin-like growth factor 1 (IGF-1) plays significant role in growth and development. Crucial role of IGF-1 was discovered inter alia through studies involving deficient patients with short stature, including SPIGFD individuals. Noteworthy, despite disturbances in proper growth, elevated values for selected stem cell populations were found in IGF-1 deficient patients. Therefore, here we focused on investigating role of these cells - very small embryonic-like...

hrp0095p2-279 | Thyroid | ESPE2022

Evaluating the role of circulating dendritic cells in methimazole-treated pediatric Graves’ disease patients

Bossowski Artur , Grubczak Kamil , Starosz Aleksandra , Stozek Karolina , Bossowski Filip , Moniuszko Marcin

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune inflammation. GD occurs more frequently in adults than in children, however, pediatric patients are a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at every stage of treatment administered. Dendritic cells (DCs) are considered a link between innate and adaptive immunity. DCs as antigen-presenting cells (APCs) are involved in antigen presentatio...

hrp0095p2-281 | Thyroid | ESPE2022

Effects of therapy on Th1, Th17, Th22 and Bregs in pediatric patients with Graves' disease

Stożek Karolina , Grubczak Kamil , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin , Bossowski Artur

Introduction: The precise pathogenesis of Graves’ disease (GD) still remains unclear, especially in the field of immunological aspects. Thyroid infiltration by reactive T and B lymphocytes plays a crucial role in the course of autoimmune thyroid diseases (ATD). Previous pattern of inflammation process was characterized by the presence of two antagonistic groups of T effector or also called- helper cells: Th1 and Th2. Recently, more attention is paid to T...

hrp0094p1-199 | Thyroid B | ESPE2021

New p.Ser237Asn Activating Mutation At The TSHR Receptor, Causing Familial Non- Autoimmune Hyperthyroidism

Bossowski Artur , Grigore Teodora , Makkonen Kristiina , Bossowski Filip , Jannari Meeri , Kero Jukka ,

Background: The pathogenesis of hyperthyroidism varies greatly, with familial non-autoimmune autosomal dominant hyperthyroidism being a rare cause. In patients who are genetically related, thyrotoxicosis develops without the clinical features of autoimmunity. In this study, we present five family members with familial hyperthyroidism who have a confirmed mutation of p.Ser237Asn in the TSHR receptor.Case Report: Our patient, a 13,5- year-...

hrp0097rfc12.5 | Thyroid | ESPE2023

Application of Shear Wave Elastography (SWE) in the ultrasound evaluation of thyroid nodules in children and adolescents

Borysewicz-Sańczyk Hanna , Bossowski Filip , Sawicka Beata , Michalak Justyna , Dzięcioł Janusz , Bossowski Artur

Introduction: Shear wave elastography (SWE) is an ultrasound diagnostic method used to measure tissue stiffness. Since the mechanical properties of tissue involved in the pathological process are changed, SWE might indicate regions of the examined tissue covered by the disease. It is well documented, that SWE helps differentiate benign and malignant nodules in thyroid gland in adults, however there are still few studies on application of SWE in thyroid diagnos...

hrp0097p1-197 | Thyroid | ESPE2023

Effects of methimazole therapy on effector T and B regulatory cells in pediatric patients with Graves' disease

Stożek Karolina , Grubczak Kamil , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin , Bossowski Artur

Introduction: The incidence of autoimmune thyroid diseases (ATD) is constantly rising. Graves’ disease (GD) remains the most common cause of thyrotoxicosis in pediatric population, but the exact pathogenesis of GD is still not fully understood. The immunological basis of ATD assumes an imbalance between effector and regulatory T lymphocytes. B regulatory cells (Breg) are able to suppress the pro-inflammatory properties of effector T cells. Methimazole (M...

hrp0097p1-589 | Thyroid | ESPE2023

Thyrotropin receptor stimulating antibodies in pediatric patients with Graves’ diseases using ultra-rapid turbo bioassay

Bossowski Artur , Hatun Burak , Sawicka Beata , Stożek Karolina , Bossowski Filip , J Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 90-100% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in a pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in patient with Hashimoto’s thyroiditis using a novel and ultra-rapid TSAb andTBAb bioassay.<p class="abstex...

hrp0095p2-84 | Diabetes and Insulin | ESPE2022

Assessment of serum concetrations of decorin, vaspin and kallistatin in children with type 1 diabetes

Polkowska Agnieszka , Bossowski Filip , Żelazowska-Rutkowska Beata , Marcinkiewicz Katarzyna , Nesterowicz Miłosz , Leoniuk Rafał , Bossowski Artur

The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study included 88 ch...

hrp0095p2-289 | Thyroid | ESPE2022

Retrospective assessment of malignant thyroid nodules in a group of polish children and adolescents involving elastography

Borysewicz-Sańczyk Hanna , Sawicka Beata , Karny Agata , Bossowski Filip , Marcinkiewicz Katarzyna , Rusak Aleksandra , Dzięcioł Janusz , Bossowski Artur

Introduction: Thyroid nodules occur in 1.8% children which is not so often in comparison to adults (19–68%), but in children they appear to be at higher risk of malignancy (22–26% vs.5–10% respectively). It has been shown that the probability of thyroid nodules malignancy correlates with the presence of characteristic ultrasonographic features. Elastography - the noninvasive ultrasound imaging technique based on estimation of the tissue flexi...

hrp0097p1-532 | Multisystem Endocrine Disorders | ESPE2023

Prevalence of endocrinopathies in a cohort of patients with Rett syndrome: a double center observational study

Pepe Giorgia , Stagi Stefano , Corica Domenico , Coco Roberto , Di Rosa Gabriella , Bossowski Filip , Skorupska Magdalena , Aversa Tommaso , Wasniewska Malgorzata

Objective: to assess the prevalence of endocrinopathies in a pediatric population of Rett syndrome (RTT) patients.Design: retrospective observational double center study.Methods: 51 caucasian patients (47 girls, 4 boy) with genetically confirmed diagnosis of RTT were enrolled (mean age: 9.65&pm;5.9 years, range: 1-18 years). The patients were referred from the Rett Center of two It...