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hrp0082p1-d1-111 | Fat Metabolism & Obesity | ESPE2014

A Multiplatform Non-targeted Metabolomics Approach to Investigate Insulin Resistance Associated to Obesity in Childhood

Mastrangelo Annalaura , Martos-Moreno Gabriel , Garcia Antonia , Ruperez Francisco , Chowen Julie , Perez-Jurado Luis , Barbas Coral , Argente Jesus

Background: Childhood obesity is often associated with insulin resistance (IR), which is a key risk factor for the development of comorbidities. The etiologic relation between insulin resistance and obesity is still not completely understood.Objective: In this study a multiplatform metabolomics approach was applied for the first time to elucidate the metabolic alterations in obese children with or without IR. Metabolomics is the revolutionary strategy of...

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hrp0097p1-253 | Fat, Metabolism and Obesity | ESPE2023

Effect of growth hormone on thermogenic and endocrine activity of brown adipose tissue and on the lipidome of children born small for gestational age

Murillo-Vallés Marta , González-López Lorena , Valls-Llussà Aina , González-Riaño Carolina , Cereijo-Tellez Rubén , Jimenez-Pavón David , Barbas Coral , Villarroya Francesc , Sánchez-Infantes David

Introduction: Brown adipose tissue (BAT) secretes molecules capable of modulating systemic metabolism. Growth hormone (GH) has hyperglycemic action, produces lipolysis and increases muscle mass. However, there are no human studies on its effect on the BAT and lipidome.Aim: To evaluate the effect of GH on BAT and lipidome in small for gestational age (SGA) patients and its relationship with adherence to treatment.<p c...

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ESPE Abstracts

A Multiplatform Non-targeted Metabolomics Approach to Investigate Insulin Resistance Associated to Obesity in Childhood

Effect of growth hormone on thermogenic and endocrine activity of brown adipose tissue and on the lipidome of children born small for gestational age

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