hrp0082p1-d2-251 | Thyroid (1) | ESPE2014

Triiodothyronine-Predominant Graves’ Disease (T3-P-GD): Description and Management in Childhood

Harvengt Julie , Boizeau Priscilla , Zenaty Delphine , Paulsen Anne , Simon Dominique , Crepon Sophie Guilmin , Alberti Corinne , Carel Jean-Claude , Leger Juliane

Background: T3-P-GD, a severe, rare disorder well known in adults, has not previously been described in children. It is characterized by persistently high serum fT3 concentration and normal, or even low, fT4 concentration during drug treatment. This condition is associated with very high titers of TRAb and large goiters, but its pathogenesis remains unclear. The recognition of this form of GD in children is of particular importance, as higher antithyroid ...

hrp0089p2-p382 | Thyroid P2 | ESPE2018

Neonatal Monitoring of Newborns Born from Mothers with Graves’ Disease: Results of a Retrospective Monocentric Study

Dumaine Cecile , Crepon Sophie Guilmin , Pages Justine , Chevenne Didier , Rosenblatt Jonathan , Storey Caroline , Martinerie Laetitia , Carel Jean-Claude , Zenaty Delphine , Leger Juliane , Simon Dominique

Background: Neonates born from mothers with GravesÂ’ disease are at risk to develop hyperthyroidism due to placental transmission of TSH-receptor antibodies. Neonatal hyperthyroidism should be effectively diagnosed and treated to prevent severe complications of this disease (cardiac symptoms, poor weight gain, severe neurological manifestations).Objectives: To describe the post-natal follow-up of neonates born from women with GravesÂ’ disease.</p...