hrp0084p3-866 | Fat | ESPE2015

The Effectiveness of a Comprehensive and Personalized Plan of Action in the Prevention and Management of Overweight and Obesity in Childhood and Adolescence

Papadopoulos George , Farakla Ioanna , Bakopoulou Sophia , Giannios Christos , Koui Eleni , Georgiou Alexandra , Romas Stamatis , Terzioglou Eleni , Koniari Eleni , Papathanasiou Chryssanthi , Kassari Penio , Nicolaides Nicolas , Critselis Elena , Manios Yannis , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem of our century, and accounts for a significant increase in morbidity and mortality in adulthood.Objective and hypotheses: To investigate the effectiveness of a comprehensive and personalized plan of action in the prevention and management of overweight and obesity in childhood and adolescence.Method: 470 children and adolescents (mean age±SEM: 9...

hrp0092p3-275 | Late Breaking Abstracts | ESPE2019

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Normal-Weight, Overweight and Obese Adolescent Females

Bacopoulou Flora , Apostolaki Despoina , Mantzou Aimilia , Doulgeraki Artemis , Pałasz Artur , Koniari Eleni , Efthymiou Vasiliki

Background: The Spexin gene is considered the most dysregulated in obese human fat with an almost complete absence of expression in obese human fat in comparison with non-obese fat tissues. Limited data from human and animal studies suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity.Objective: The aim of this study was to compare serum spexin concentrations betw...

hrp0084p3-848 | Fat | ESPE2015

Increased Prevalence of 25-Hydroxyvitamin D Insufficiency and Deficiency among Overweight and Obese Children and Adolescents in Greece

Giannios Christos , Farakla Ioanna , Papadopoulos Georgios , Koniari Eleni , Papathanasiou Chrysanthi , Kassari Penio , Charmandari Evangelia

Background: The prevalence of childhood obesity has increased dramatically in the last decades and accounts for a significant increase in morbidity and mortality in adulthood.Objective and hypotheses: To determine the prevalence of 25-hydroxyvitamin D insufficiency and deficiency in overweight and obese children and adolescents.Method: 350 (n=350) children and adolescents (153 males (M), 197 females (F)) were recruited to ...

hrp0097p1-258 | Fat, Metabolism and Obesity | ESPE2023

An interesting case of combined familial hyperlipidaemia and high lipoprotein (a) in a 20-month-old girl

Karabouta Zacharoula , Simeoforidou Elpida , Georgoulia Konstandina , Koniari Eleni , Bisbinas Alexia , Chrousos George

Introduction: Familial hypercholesterolaemia(FH) is a genetic disorder affecting approximately 1 in 250 people, resulting in high levels of low-density lipoprotein Cholesterol(LDL-C), increasing the likelihood of developing cardiovascular disease(CVD) at a younger age. Lipoprotein (a)(Lp(a)) is another risk factor for atherosclerosis, elevated in 20-25% of people and 90% genetically determined, only slightly reduced by diet, exercise and medication.<p clas...

hrp0097p2-237 | Diabetes and Insulin | ESPE2023

Genetic evidence for a causal relationship between severe hyperlipidemia and Type 1 Diabetes.

Koniari Eleni , Hatziagapiou Kyriaki , Skouma Anastasia , Chaliotis Fotis , Drosatou Panagiota , Tsani Evelina , Blatsa Vasiliki , Chrousos George

Background: In type 1 diabetes (T1D), the pancreatic ╬▓cells are selectively destroyed by the immune system resulting in absolute insulin deficiency. It has been long established that approximately half of the genetic risk for T1D is conferred by genetic loci associated with ╬▓-cell function, apoptosis, and regeneration.Aim: We report the case of a 6- year-old boy with new onset type T1D, and identified genetic l...

hrp0089fc1.5 | Adrenals &amp; HPA Axis | ESPE2018

Untargeted Plasma Metabolomics in Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies a Novel metabolic Signature

Nicolaides Nicolas C. , Ioannidi Maria-Konstantina , Koniari Eleni , Sertedaki Amalia , Klapa Maria I. , Chrousos George P. , Charmandari Evangelia

Background: Tissue glucocorticoid sensitivity is characterized by a considerable variation in terms of therapeutic response and side effects to synthetic glucocorticoids. The multi-metabolite concentration profile measured by untargeted plasma metabolomics provides a comprehensive metabolic signature that might be used in clinical practice.Objective and Hypotheses: To investigate the usefulness of plasma metabolomics in identifying a metabolic signature ...

hrp0086fc1.2 | Adrenals | ESPE2016

Transcriptomic Analysis in Healthy Subjects with Differences in Tissue Sensitivity to Glucocorticoids Identifies Novel Disease-associated Genes

Nicolaides Nicolas C. , Polyzos Alexandros , Koniari Eleni , Lamprokostopoulou Agaristi , Golfinopoulou Eleni , Papathanasiou Chryssanthi , Sertedaki Amalia , Thanos Dimitris , Charmandari Evangelia

Background: Glucocorticoids exert profound immune-modulating effects and regulate the expression of genes involved in cell cycle progression and apoptosis. Synthetic glucocorticoids are the most potent agents used in the treatment of inflammatory, autoimmune and lymphoproliferative disorders. Considerable variation in response to therapeutic doses of glucocorticoids exists among individuals, as evidenced by differences both in disease response and in the incidence of glucocort...

hrp0094p1-106 | Adrenal B | ESPE2021

Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies a Novel Proteomic Signature

Nicolaides Nicolas C. , Makridakis Manousos , Stroggilos Rafael , Koniari Eleni , Papageorgiou Ifigeneia , Sertedaki Amalia , Zoidakis Jerome , Charmandari Evangelia ,

Background: Tissue sensitivity to glucocorticoids is characterized by significant inter-individual variation in terms of therapeutic response and susceptibility to several stress-related disorders. Proteomics approaches, combined with appropriate bioinformatics analysis, offer a comprehensive description of molecular phenotypes with clear links to human disease pathophysiology.Objective and Hypotheses: To investigate the usefulness of pl...