hrp0084p2-579 | Thyroid | ESPE2015

Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis; A Single-Centre Study

Keskin Meliksah , Savas-Erdeve Senay , Aycan Zehra

Background: There is currently an inadequate number of studies on nodule and malignancy development in children and adolescents with Hashimoto thyroiditis (HT).The aim of our study was to determine the rate of thyroid nodules and the nodule malignancy rate in our pediatric HT patients.Material and methods: Patients who were diagnosed with HT between 2004 and 2013 were included in the study. The HT diagnosis was made with the elevation of anti-TPO and ant...

hrp0089p2-p082 | Diabetes & Insulin P2 | ESPE2018

IGF-1 Relationship with Growth Velocity in Precocious Puberty with GnRHa Treatment

Sahin Nursel Muratoglu , Cetinkaya Semra , Erdeve Senay Savas , Aycan Zehra

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

hrp0086p2-p682 | Growth P2 | ESPE2016

Calcaneal Apophysitis (Sever’s Disease) Development in a Case Using Growth Hormone

Kurnaz Erdal , Erdeve Senay Savas , Aycan Zehra , Cetinkaya Semra

Background: Orthopedic complications related to the GH are rare and there is no clear pathological association between the use of GH and these complications. Calcaneal apophysitis is an inflammation of the apophysis and is caused by the constant pull of the Achilles tendon. A literature search did not reveal a similar case of calcaneal apophysitis during GH use.Case presentation: A 13-year-old male receiving GH treatment for isolated GH deficiency presen...

hrp0092fc10.6 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Evaluation of Basal and GNRH-stimulated AMH Levels in Central Precocious Puberty, Peripheral Precocious Puberty and Premature Thelarche

Sahin Nursel Muratoglu , Yilmaz Aslihan Arasli , Erdeve Senay Savas , Cetinkaya Semra , Aycan Zehra

Objective: AMH decreases by 30% in the first two years following puberty. Although it is known that AMH is associated with FSH and LH, the AMH response to rapid changes in GnRH is not known clearly in puberty. It has been shown that AMH levels in central precocious puberty (CPP) are lower than in premature thelarche (PT), but the levels of AMH in peripheral precocious puberty (PPP) have not been evaluated. The aim of this study was to evaluate the basal an...

hrp0092p1-181 | Diabetes and Insulin (1) | ESPE2019

A Case of Prohormone Convertase Deficiency Diagnosed with Type 2 Diabetes Mellitus

Kucukali Gulin Karacan , Savas-Erdeve Senay , Cetinkaya Semra , Keskin Meliksah , Bulus Ayse Derya , Aycan Zehra

Background: Prohormone convertase is an enzyme that converts many biologically inactive prohormones into biologically active peptides. Its deficiency is characterized by deficiency of variable levels in all the hormone systems. In relation to this, postprandial hypoglycemia has been reported but, a case of prohormone convertase deficiency presenting with a diagnosis Type 2 diabetes mellitus has not been previously reported.Case p...

hrp0092p1-284 | Thyroid (1) | ESPE2019

Different Endocrine Affects in DICER-1 Syndrome

Yilmaz Aslihan Arasli , Aycan Zehra , Erdeve Senay Savas , Çetinkaya Semra

Introduction: DICER1 syndrome is a pleotropic, autosomal dominant familial genetic tumor predisposition syndrome. DICER1 somatic + germ-line mutations (double hit hypothesis); cystic nephroma; pleuropulmonerblastoma, ovarian sex cord-stromal tumors, multinodular goitre (MNG) are associated with many conditions such as differentiated thyroid cancer, pituitary blastoma. We presented three cases, two of whom were siblings, who had been consulted because of no...

hrp0092p1-330 | Diabetes and Insulin (2) | ESPE2019

Evaluation of Clinical, Laboratory and Therapeutic Features and Long Term Follow-up Results in 44 Cases with Genetic Diagnosis of MODY; Single Center Experience

Ozalkak Servan , Keskin Meliksah , Çetinkaya Semra , Erdeve Senay Savas , Bayramoglu Elvan , Aycan Zehra

Introduction-Aim: MODY;It is an autosomal dominant, rare type of diabetes that occurs in young people as a result of mutations of beta cell function and genes involved in insulin secretion. The cases may be misdiagnosed as Type1 and Type2 diabetes. Considering that MODY is clinically and genetically heterogeneous, the findings should be evaluated correctly. It is important to define the clinical-laboratory characteristics of diagnosis and follow-up of patients...

hrp0092p2-198 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Evaluation of Diagnosis, Follow-up and Treatment Results of Growth Hormone in Rare Diseases; 10 Year Single Center Experience

Aycan Zehra , Arasli Yilmaz Aslihan , Yel Servet , Savas Erdeve Senay , Çetinkaya Semra

Introduction: Growth hormone therapy (GHT); have been used in rare diseases such as growth hormone deficiency (GHD), panhipopituitarism (PHP), intrauterine growth retardation (IUGR), Turner Syndrome(TS) for many years while the effects of diagnostic timing on the treatment results are known. However,data on the diagnosis and treatment processes of these diseases are limited in our country. The aim of this study was to evaluate the results of diagnosis, follow-...

hrp0092p2-234 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Evaluation of Clinical Features and Treatment Responses of Cases with Hyperprolactinemia

Özalkak Servan , Bayramoglu Elvan , Savas Erdeve Senay , Çetinkaya Semra , Aycan Zehra

Aim: In this study, we planned to evaluate the patients with hyperprolactinemia etiology, clinical features and treatment responses.Material and Method: We evaluated retrospectively the features, clinical follow-up data and treatment responses of the patients with hyperprolactinemia in our pediatric endocrinology clinic between 01.01.2012-31.12.2018.Results: Thirty-one patients wit...

hrp0092p3-9 | Adrenals and HPA Axis | ESPE2019

Late Onset 11 Beta Hydroxylase Deficiency: Two Cases

Bayramoğlu Elvan , Aycan Zehra , şavas Erdeve Şenay , Çetinkaya Semra

Introduction: Differential diagnosis should include congenital adrenal hyperplasia (CAH) in premature adrenarche patients. Clinically, it is possible to diagnose late onset and simple virilisation CAH caused by 21 hydroxylase deficiency because the criteria are better defined and genetic tests are widely available. But especially late onset 11 Beta hydroxylase deficiency can be very difficult to diagnose because the diagbostic criteria are not well defined and...