hrp0092p3-190 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Structural Pituitary Abnormality and Dysfunction Associated with Charge Syndrome

Karachaliou Feneli , Skarakis Nikitas , Mitrogiorgou Marina , Simatou Aristophania , Papaevangelou Vassiliki

Background: CHARGE is an autosomal-dominant syndrome which includes a variable combination of coloboma of the eye, heart malformations, atresia of the choanae, retardation of growth and development, and genital and ear abnormalities CHARGE syndrome has rarely been associated with anterior pituitary dysfunction and with structural abnormalities of the pituitary gland only twice. We report the case of a child with CHARGE association and congenital hypopituitaris...

hrp0092p1-74 | GH and IGFs | ESPE2019

Recombinant GH Treatment in Child with Pseudopseudohypoparathyroidism Associated with Growth Hormone Deficiency

Karachaliou Feneli , Skarakia Nikitas , Mitrogiorgou Marina , Simatou Aristophania , Peppa Melpomeni , Papaevangelou Vassiliki

Background: Pseudopseudohypoparathyroidism (PPHP) is a rare variant of pseudohypoparathyroidism (PHP) type I, with typical anatomical abnormalities known as Albright's hereditary osteodystrophy (AHO)(short stature, brachydactyly particularly involving metacarpals and metatarsals, round face, stocky build, ectopic ossifications and a number of possible associated defects), but with normal calcium, phosphate and PTH levels and normal response to exogenous PT...

hrp0092p2-40 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Reduced Bone Mineral Density in Children with Inflammatory Bowel Disease without Exposure to Corticosteroid Treatment

Mitrogiorgou Marina , Karachaliou Feneli , Skarakis Nikitas , Simatou Aristophania , Peppa Melpomeni , Fessatou Smaragdi , Papaevangelou Vassiliki

Objectives: Bone mineral density is reduced in children and adolescents with inflammatory bowel disease (IBF). The exact cause of this reduction is not known and is often attributed to corticosteroid use. The aim of the study was to evaluate bone mineral density in children with IBF without previous corticosteroid exposure.Methods: Twelve children aged 8-17years with IBF (8 with Crohn's disease and 4 with ulcerative ...

hrp0092p2-214 | Multisystem Endocrine Disorders | ESPE2019

Celiac Disease and Endocrine Autoimmunity in Children and Adolescents

Mitrogiorgou Marina , Karachaliou Feneli , Karalexi Maria , Georgantzi Maria , Kontaki Helen , Foukas Periklis , Triantafyllou Konstantinos , Fesssatou Smaragdi

Objectives: Celiac disease (CD) is a life-long inflammatory disease of the gastrointestinal tract that affects genetically susceptible individuals and is associated with several autoimmune diseases. The aim of the study was to evaluate the prevalence of coexistent autoimmune endocrine disorders in children and adolescents diagnosed with CD.Patients and Methods: Children diagnosed with CD in the Paediatric Gastroenterolog...

hrp0086p2-p942 | Thyroid P2 | ESPE2016

Euthyroid Hashimoto Thyroiditis in Children: Evolution Over Time

Karachaliou Feneli , Kafetzi Maria , Vlachopapadopoulou Elpis , Thomas Dimitris , Kaloumenou Irene , Fotinou Aspasia , Karavanaki Kyriaki , Michalakos Stefanos

Background: The natural evolution of euthyroid Hashimoto thyroiditis (HT) varies among children and treatment in children with HT and normal/mild elevated serum TSH is controversial.Objective and hypotheses: The aim was to study the natural course of HT in children and evaluate predictive factors of thyroid functionMethod: We evaluated data from 87 children retrospectively (63 girls, 24 boys), mean age 10.6±3.2yrs, with HT [an...

hrp0086p2-p969 | Thyroid P2 | ESPE2016

An Unusual Presentation of Hashimoto Thyroiditis (HT) and Precocious Puberty: The Van Wyk-Grumbach Syndrome

Leka-Emiri Sofia , Karachaliou Feneli , Fotinou Aspasia , Petrou Vassilis , Michalakos Stefanos

Background: The association of primary hypothyroidism and isosexual precocious pseudopuberty in females was first described in 1960 by Van Wyk and Grumbach. The unique elements that lead to the diagnosis are FSH-dominated sexual precocity with non advanced bone age in the presence of hypothyroidism.Objective and methods: Describe an 8.5 years old girl with hypothyroidism due to HT and clinical and hormonal features of Van-Wyk and Grumbach syndrome.<p...

hrp0082p2-d2-339 | Diabetes (1) | ESPE2014

Direct Costs of Diabetes Care in Pediatric Patients with Type 1 Diabetes in Greece

Karachaliou Feneli , Athanasakis Konstantinos , Tsendidis Charalabos , Kitra Maria , Michalakos Stefanos , Karavanaki Kyriaki

Background: Type 1 diabetes (T1DM) is a chronic disease with increasing incidence and major impact on the health care costs.Objective and hypotheses: To estimate the direct cost of pediatric T1DM in the Greek National Health System (NHS) and its distribution by service category.Method: This is a retrospective cost-of-illness study, focusing on the direct costs from the healthcare system’s point of view. All patients aged 0&#15...

hrp0082p2-d3-347 | Diabetes (2) | ESPE2014

Predictors of Direct Costs of Pediatric Diabetes in Greece

Karachaliou Feneli , Athanasakis Konstantinos , Tsendidis Charalabos , Kitra Maria , Michalacos Stefanos , Karavanaki Kyriaki

Bakground: There is a dearth of data examining the direct costs of diabetes type 1 (T1DM) in Greece and their predictors.Objective and hypotheses: To examine the predictors of elevated direct costs of T1DM in the National Health System in Greece.Method: All patients diagnosed with T1DM, who were followed in the Diabetic Clinic of the University Pediatric Department of one of the two major Children’s hospitals in Athens, from 1...

hrp0082p2-d2-422 | Growth Hormone (1) | ESPE2014

Perceptions and Expectations of Patients and their Families for the Effects of GH Treatment

Drosatou Chrysoula , Vlachopapadopoulou Elpis-Athina , Karachaliou Feneli , Petrou Vassileios , Kaloumenou Eirini , Michalakos Stefanos

Background: Children’s and parents’ expectations regarding GH therapy results have been previously assessed. However, there are limited data on children’s and adolescents perceptions of their own body size as compared with that of their age-related peers, as well as their expectations of their final stature.Objective and hypotheses: To evaluate the perceptions of GH treated children and their families for the child’s stature and to as...

hrp0082p2-d2-473 | Growth (1) | ESPE2014

GH Deficiency in a Child With De Novo 2q31.1 Microdeletion

Kaloumenou Irene , Karachaliou Feneli , Vlachopapadopoulou Elpis-Athina , Fotinou Aspasia , Michalacos Stefanos

Background: The clinical phenotype of the chromosome 2q31 deletion syndrome consists of a variety of limb abnormalities and other skeletal defects, craniofacial dysmorhic features, developmental delay, and other not specific congenital anomalies.Objective and hypotheses: To describe a patient with 2q31.1 microdeletion syndrome and short stature, diagnosed with GH deficiency.Method: We describe a 5 years and 4 months girl with devel...