hrp0092p3-254 | Thyroid | ESPE2019

Encephalitis Associated with Autoimmune Thyroiditis: A Rare Cause of Encephalopathy In Children

Fudvoye Julie , Lebrethon Marie-Christine , Leroy Patricia , Seghaye Marie-Christine , Parent Anne-Simone

A ten year old girl was brought by the emergency mobile service for a persistent status epilepticus despite administration of Diazepam on site. She had presented headaches for the last three days and one episode of fever was suspected but not measured four days earlier. She had one episode of dizziness five days earlier.Persistent status epilepticus required invasive ventilation as well as deep sedation with Levetiracetam, Midazolam, ketamine, phenytoin,...

hrp0082p2-d2-541 | Puberty and Neuroendocrinology (1) | ESPE2014

Normal Minipuberty in a Patient with DAX1 Mutation: a Reliable Marker of the Function of the Hypothalamic–Pituitary–Gonadal Axis?

Fudvoye Julie , Christine Lebrethon Marie , Pierre Bourguignon Jean , Simone Parent Anne

Background: We report here the case of a 5-week-old male patient, referred to the hospital because of failure to thrive. An adrenal insufficiency was diagnosed and the genetic testing showed a mutation in the DAX1 gene leading to a premature stop codon.In addition to adrenal hypoplasia congenita, DAX1 mutation is known to be classically associated with hypogonadotrophic hypogonadism which is mostly characterized by absence of onset of puberty and inferti...

hrp0084p3-1251 | Programming & Misc. | ESPE2015

Sexually Dimorphic Methylation of SF-1 in Rat Placenta after Gestational Exposure to BPA

Fudvoye Julie , Dehan Pierre , Lienard Mehdi , Trooskens Geert , Gerard Arlette , Bourguignon Jean-Pierre , Parent Anne-Simone

Background: Gestational exposure to endocrine disrupting chemicals (EDCs) can impact the control of sexual differentiation by altering the hormonal environment of the foetus. Prenatal exposure to BPA, for instance could lead to disorders of sexual development. At the interface between the mother and the foetus, the placenta plays a key role in foetal programming and responds to environmental stressors in a sex specific manner. Epigenetics has appeared to be a key mechanism for...

hrp0094p2-260 | Growth hormone and IGFs | ESPE2021

Current growth hormone therapy practices in Belgium for the treatment of short children born small for gestational age

Thomas Muriel , Casteels Kristina , Rochtus Anne , van der Straaten Saskia , Van Aken Sara) , Fudvoye Julie , Boros Emese , Dotremont Hilde , Vanbesien Jesse , Mouraux Thierry , Chivu Olimpia , Logghe Karl , Reynaert Nele , Massa Guy , Depoorter Sylvia , Klink Daniel , Becker Marianne , Lysy Philippe , De Schepper Jean ,

Background and Aim: Recombinant growth hormone (GH) is reimbursed for the treatment of short stature (<-2.5 Z-score) in children born small for gestational age (SGA) without postnatal growth, aged ≥ 4 years with a height Z-score >1 below mid-parental height (MPH). We wanted to determine the current GH prescribing practices by pediatric endocrinologists (PE) for SGA related short stature and document the percentages of treated children at risk for...