hrp0082p2-d1-257 | Adrenals & HP Axis | ESPE2014

Growth Pattern in Infants with Congenital Adrenal Hyperplasia During the First Year of Life

Elsedfy Heba , Hamza Rasha

Background/aims: Several studies demonstrated rapid growth during the first year of life in infants with congenital adrenal hyperplasia (CAH) which has a considerable effect on final adult height. Whether decreased height potential is caused by inadequate suppression of adrenal androgens, excess steroid therapy or salt wasting itself is a matter of debate. Thus, we aimed to analyze growth pattern in infants with CAH during first year of life and the effect of therapy on those ...

hrp0089p3-p059 | Bone, Growth Plate & Mineral Metabolism P3 | ESPE2018

Assessment of Vitamin D Status in Healthy Pre-pubertal Egyptian Children

Hamza Rasha , Toeima Nadin , Hamed Amira

Background: Despite a shining sun all through the year, vitamin D deficiency is still prevalent in Egyptian children which suggests a relative resistance to vitamin D in Egyptian population.Aim: To assess 25(OH)D status in healthy pre-pubertal Egyptian children and to relate its levels to anthropometric parameters in these children.Methods: Sixty healthy children aged between 3 and 10 years coming to the Outpatient clinic, Children...

hrp0086p2-p158 | Bone & Mineral Metabolism P2 | ESPE2016

Anthropometric and Nutritional Parameters in Egyptian Children with Osteogenesis Imperfecta: Effect of Zoledronic Acid Therapy

Hamza Rasha , Abdelaziz Tarek , Elakkad Magdy

Background: Patients with osteogenesis imperfect (OI) present with various degrees of short stature and nutritional disorders.Objective and hypotheses: To evaluate anthropometric and nutritional parameters in OI children and their variability among various types.Methods: Eighty-four patients with OI (types I, II, and IV) were subjected to the following anthropometric measurements: standing height (Ht), sitting height (SH), arm span...

hrp0084fc5.6 | Endocrine Oncology/Turner | ESPE2015

Anti-Müllerian Hormone Levels in Patients with Turner Syndrome: Relation to Karyotype, Pubertal Development and GH Therapy

Hamza Rasha , Mira Marwa , Hamed Amira

Background: Gonadal dysgenesis in Turner syndrome (TS) results in pubertal delay or failure and infertility in most patients. However, up to 30% of girls with TS have spontaneous pubertal development and 2–5% have regular menstrual cycles before the onset of premature menopause. Serum anti-Mullerian (AMH) levels reflect the ovarian reserve in females, even in childhood.Objective and hypotheses: To Asses serum AMH levels in patients with TS and its r...

hrp0084p3-1024 | Growth | ESPE2015

Vitamin D Status in Pre-Pubertal Children with Isolated Idiopathic GH Deficiency: Effect of GH Therapy

Hamza Rasha , Hamed Amira , Abdelmohsen Rehab

Background: Some studies suggested a correlation between vitamin D (VD) and the GH-IGF1 but few studies, and with controversial results, have prospectively analysed the vitamin D status in children before and after GH treatment.Objective and hypothesis: To assess VD status in pre-pubertal children with idiopathic GH deficiency (GHD); and to evaluate effect of GHD and GH treatment on VD levels.Methods: 50 pre-pubertal children with ...

hrp0089p2-p125 | Fat, Metabolism and Obesity P2 | ESPE2018

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Egyptian Obese Children and Adolescents: Relation to Hypertension Risk

Hamza Rasha , Elkabbany Zeinab , Kamal Tarek , Sedhom Mina

Background: Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of ACE candidate genes for development of the obesity-hypertension phenotype early in life.Aim: To screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the gene encodi...

hrp0086p1-p636 | Growth P1 | ESPE2016

The Use of Tissue Doppler Imaging in Assessing Right and Left Ventricle Diastolic Function in Children with Growth Hormone Deficiency before and after 1-Year Therapy with Growth Hormone

Khalaf Randa , Elkholy Mohamed , Elsedfy Heba , Kotby Alyaa , Hamza Rasha , Youssef Omneya

Background: Growth Hormone (GH) therapy has a positive effect on many parameters including metabolic and physiologic functions as well as its effect on growth. It has also been shown that GH therapy exerts a significant effect on cardiac morphology and function as evidenced by echocardiographic findings.Aim: To investigate left and right ventricle (LV, RV) diastolic function by Tissue Doppler imaging (TDI) in pre-pubertal growth hormone deficient (GHD) c...

hrp0086p2-p645 | Growth P2 | ESPE2016

Effect of One-Year Growth Hormone Therapy on Serum Levels of Ghrelin and Leptin in Children with Growth Hormone Deficiency and their Correlations with Cardiac Functions and Dimensions

Khalaf Randa , ElKholy Mohamed , Elsedfy Heba , Kotby Alyaa , Hamza Rasha , Youssef Omneya , Mahmoud Nermine

Background: Controversial data on ghrelin and leptin concentrations in patients with growth hormone deficiency (GHD) have been published. Little has addressed the correlation between Ghrelin and leptin with cardiac functions in patients with GHD.Aim: To investigate the effect of one year Growth hormone (GH) therapy on serum levels of ghrelin and leptin in children with GHD and to study their correlations with cardiac functions and dimensions in patients ...

hrp0082fc2.3 | Bone & Mineral | ESPE2014

Calcium Homeostasis in Adolescents with β-Thalassemia Major: Effect of i.m. Injection of a Megadose of Cholecalciferol

Elkholy Mohamed , Elalfy Mohsen , Hamza Rasha , Mahmoud Nermine , Saleh Mohamed , Elsedfy Heba

Background: The etiology of bone disease in thalassemic patients is multifactorial. Factors such as hormonal deficiency (especially gonadal failure), bone marrow expansion, increased iron stores, desferioxamine toxicity, calcium, and vitamin D deficiency seem to have a serious impact on impaired bone metabolism in this disease.Objectives: To estimate the frequency of calcium homeostasis abnormalities in adolescent thalassemic patients, and to investigate...

hrp0094fc7.3 | Fetal Endocrinology and Multisystem Disorders | ESPE2021

European Training Requirements for Competency in Paediatric Endocrinology and Diabetes 2021

Busiah Kanetee , Peet Aleksandr , Tornese Gianluca , Weintrob Naomi , Patel Leena , Hamza Rasha ,

Background: A Europe-wide training program in Paediatric Endocrinology and Diabetes (PED) was initiated by Professor Leo Van den Brande in 1976. PED was recognised as a subspecialty in 1996 by the European Board of Paediatrics (EBP), which is a section of the Union of European Medical Specialists (UEMS). UEMS aims to ensure high standards for training across Europe and the minimum requirements are set out in the European Training Requirements (ETR). The first ...