hrp0086p1-p747 | Pituitary and Neuroendocrinology P1 | ESPE2016

Etiology, Differential Diagnosis and Clinical Course of Delayed Puberty: A Single Center Experience

Varimo Tero , Miettinen Paivi , Kansakoski Johanna , Raivio Taneli , Hero Matti

Background: Delayed puberty (DP) is generally considered a benign condition. We investigated the diagnoses underlying DP and its outcome predictors.Objective: A retrospective chart review which included clinical and biochemical data of 174 boys and 70 girls evaluated for DP in a single tertiary care center between 2004 and 2014.Results: Thirty etiologies that underlie DP were identified. No markers of clinical value could be identi...

hrp0086p2-p780 | Pituitary and Neuroendocrinology P2 | ESPE2016

Precocious Puberty: A Single Academic Center Experience

Huttunen Heta , Varimo Tero , Miettinen Paivi , Hero Matti , Raivio Taneli

Background: The frequency of makorin RING-finger protein 3 gene (MKRN3) mutations in Finnish patients with precocious puberty (PP) is not known. As a first step to investigate this, we describe the diagnoses underlying PP in a single academic center.Objective and hypotheses: To review the diagnoses in children who were presented with signs of PP (adrenarche excluded) at the Helsinki University Hospital, with a special emphasis on the identification of fa...

hrp0097fc6.4 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Sleeptime-excreted total urinary luteinizing hormone concentrations reveal that the onset of central puberty occurs at around the same time in boys and girls: a longitudinal study

Demir And , Hero Matti , Juul Anders , M. Main Katharina

Objectives: We designed a longitudinal study to investigate the association between central pubertal activation with age at the appearance of clinical signs of puberty. We, therefore, assessed nocturnal gonadotropin secretion which can be detected in the form of total luteinizing hormone (LH) immunoreactivity in the daytime- and sleeptime-excreted urine.Methods: Thirty healthy volunteers (17 boys and 13 girls, aged 3.4&n...

hrp0097p1-147 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Quantification of overnight urinary gonadotropin excretion predicts imminent puberty in girls: a semi-longitudinal study

Demir And , Büyükgebiz Atilla , Aydin Adem , Hero Matti

Objectives: We explored the alternative of using overnight fold change in gonadotropin levels by comparing the last-night-voided and first-morning-voided urine concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as a conceptual analogy to the invasive gonadotropin-releasing hormone (GnRH) stimulation test setting.Methods: We investigated the nocturnal changes in the immunoreactivity levels o...

hrp0092p1-88 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Etiology of Severe Short Stature: Single Center Experience

Kärkinen Juho , Miettinen Päivi J , Raivio Taneli , Hero Matti

Background: Based on growth screening rules, severe short stature (i.e. height SDS less than -3), at the age of more than 3 years, warrants diagnostic evaluation in specialized health care. In the absence of apparent underlying cause, targeted and eventually untargeted genetic studies have been proposed. However, the etiology of short stature at the severe end of the spectrum is poorly characterized.Methods: We ...

hrp0092p1-395 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Presentation and Diagnosis of Childhood Onset Combined Pituitary Hormone Deficiency: A Single Center Experience from Over 30 Years.

Hietamäki Johanna , Miettinen Päivi J. , Hero Matti , Tarkkanen Annika , Raivio Taneli

Background: We describe the incidence, etiologies and clinical features of combined pituitary hormone deficiency (CPHD) in pediatric patients from a single tertiary center.Methods: The cohort comprised of patients with CPHD, treated in the Helsinki University Hospital between 1985 and 2018. They were identified through an ICD-9/ICD-10 code search, and the clinical data were recorded from the patient charts.<p class="...

hrp0082fc14.6 | Puberty | ESPE2014

Quality of Life in Patients with Congenital Hypogonadotropic Hypogonadism

Varimo Tero , Hero Matti , Laitinen Eeva-Maria , Sintonen Harri , Raivio Taneli

Background: Little is known about the burden of disease, as evaluated by health related quality of life (HRQoL), in patients with congenital hypogonadotropic hypogonadism (CHH). We characterized the (HRQoL) in a relatively large and well-characterized population of patients with CHH using the 15D, a comprehensive preference-based generic instrument in sampling dimensions for the construct of HRQoL. 15D covers most of the ‘domains of health’ emphasized in the WHO Inte...

hrp0084p2-482 | Growth | ESPE2015

Childhood Growth of Boys with Congenital Hypogonadotropic Hypogonadism

Varimo Tero , Hero Matti , Laitinen Eeva-Maria , Miettinen Paivi , Tommiska Johanna , Juul Anders , Raivio Taneli

Background: Congenital hypogonadotropic hypogonadism (CHH) provides a model to study the impact of sex steroid deficiency on childhood growth.Aims and objectives: We characterised growth patterns in male CHH patients with special emphasis on growth during the minipuberty of infancy.Methods: Growth charts of 38 men with CHH (28 from Finland and 10 from Denmark) were evaluated. Fifteen (39%) patients had representative length measure...

hrp0094p1-163 | Growth B | ESPE2021

The etiology of extreme tall stature above +3 SDS in a screened Finnish population

Karkinen Juho , Sorakunnas Eero , Miettinen Paivi J. , Raivio Taneli , Hero Matti ,

Background: Most comprehensive guidelines on tall stature suggest that extremely tall children (defined as height above +3 SDS) should be referred to specialized health care for comprehensive diagnostic work-up. However, currently the etiology of tall stature is poorly characterized and no systematic studies focusing on extreme tall stature exist.Methods: We identified all subjects with height above +3 SDS after the age ...

hrp0094p1-186 | Pituitary B | ESPE2021

Additive effect of androgens and estrogens on pubertal growth acceleration

Huttunen Heta , Varimo Tero , Huopio Hanna , Voutilainen Raimo , Tenhola Sirpa , Miettinen Paivi , Raivio Taneli , Hero Matti ,

Objective: The influence of androgens and estrogens on growth is complex, and understanding their relative roles is important for optimizing the treatment of children with various disorders of growth and puberty.Design: We examined the proportional roles of androgens and estrogens in the regulation of pubertal growth in boys with constitutional delay of growth and puberty (CDGP). The study compared 6-month low-dose intramuscular testoste...