hrp0097rfc14.2 | Late Breaking | ESPE2023

No Relationship Between Thyroid Function and ADHD – Results From a Nationwide Prospective Epidemiological Study and Mendelian Randomization

Hirtz Raphael , Grasemann Corinna , Dinkelbach Lars , Hinney Anke , Hebebrand Johannes , Peters Triinu

Introduction: Limited research has focused on the potential connection between thyroid function and attention-deficit/hyperactivity disorder (ADHD), particularly beyond prenatal effects. The few studies addressing children and adolescents have important methodological shortcomings, mainly when seeking to establish causality. To clarify this relationship, a combined epidemiological and genetic approach was adopted to overcome the methodological limitations of e...

hrp0095p1-161 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Causal Effect of Age at Menarche on the Risk for Depression: Results from a Two-Sample Multivariable Mendelian Randomization Study

Hirtz Raphael , Hars Christine , Naaresh Roaa , Hergen Laabs Björn , Antel Jochen , Grasemann Corinna , Hinney Anke , Hebebrand Johannes , Peters Triinu

Background: A fair number of epidemiological studies suggest that age at menarche (AAM) is associated with depression, but the reported effect sizes are small, and there is evidence of residual confounding. Moreover, previous Mendelian randomization (MR) studies to avoid inferential problems inherent to epidemiological studies have provided mixed findings.Methods: To clarify the causal relationship between age at menarch...

hrp0084p2-391 | Fat | ESPE2015

POMC DNA Hypermethylation Variant is Highly Associated with Obesity in Adults

Kuhnen Peter , Handke Daniela , Spranger Jochen , Fischer-Rosinsky Antje , Hinney Anke , Hebebrand Johannes , Gruters Annette , Krude Heiko

Background: POMC plays a major role in central body weight regulation. Recently we have shown that a POMC hypermethylation variant is significantly associated with obesity in children and adolescents (Kuehnen et al. PLoS Genetics 2012).Objective and hypotheses: Here we report about our extended studies to elucidate the mechanism behind the occurrence of the POMC hypermethylation variant in obese individuals.<p clas...

hrp0094p1-187 | Pituitary B | ESPE2021

The Adrenal Steroid Profile in Adolescent Depression: A Valuable Bio-Readout?

Hirtz Raphael , Libuda Lars , Hinney Anke , Focker Manuel , Judith Buhlmeier , Holterhus Paul-Martin , Kulle Alexandra , Kiewert Cordula , Hauffa Berthold , Hebebrand Johannes , Grasemann Corinna ,

Background: There is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are limited, mainly due to small sample sizes. Therefore, the present study was intended to assess whether adrenal steroids (progesterone, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, deoxycorticosterone, cortico...

hrp0094p2-370 | Pituitary, neuroendocrinology and puberty | ESPE2021

Size Matters: CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity

Hirtz Raphael , Libuda Lars , Hinney Anke , Focker Manuel , Buhlmeier Judith , Antel Jochen , Holterhus Paul-Martin , Kulle Alexandra , Kiewert Cordula , Hebebrand Johannes , Grasemann Corinna ,

Background: There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood. Moreover, the number of CAG repeats of the androgen receptor gene (AR) and the depression status (subclinical vs. overt depression) may modulate the role of testosterone, but this has not yet been studied in a clinical sample.Methods:...