hrp0092p1-310 | Diabetes and Insulin (2) | ESPE2019

Preliminary Results of Public Health Prevention Program for Diabetic Ketoacidosis in Children and Adolescent

Simunovic Marko , Skrabic Roko , Vulic Luka , Unic Ivana , Skrabic Veselin

Objectives: Diabetic ketoacidosis (DKA) is the leading cause of mortality in a type 1 diabetic mellitus (T1DM) in pediatric population. The prevalence of the DKA in the developed world ranges from 15% to 61% and in Croatia it is 33 to 36%. In the past few decades in Europe there have been no significant changes in the prevalence of DKA in patients with newly T1DM. In the previous preventive program known as the "Parma campaign", which was c...

hrp0095p1-442 | Diabetes and Insulin | ESPE2022

A Continuous Quality Improvement Effort Implemented by The Italian Network of Pediatric Diabetes Clinics

Zucchini Stefano , Bonfanti Riccardo , Lombardo Fortunato , Nicolucci Antonio , Rabbone Ivana , Schiaffini Riccardo , Vespasiani Giacomo

Pediatric diabetes management extends beyond glycemic control. A gap between guidelines and actual care exists. Standardized performance measures represent a key strategy to improve quality of care. In Italy, a non-profit initiative of continuous monitoring and quality improvement of diabetes care is in place since 2018, promoted by the ISPEDCARD association and involving the Society for Pediatric Endocrinology and diabetology (ISPED). Aim of the present work is to report the ...

hrp0095p1-76 | Fat, Metabolism and Obesity | ESPE2022

Omentin-1, vaspin, peptide YY and oxyntomodulin levels in cord blood newborns and correlation with anthropometric parameters

Mancioppi Valentina , Antoniotti Valentina , Ricotti Roberta , Solito Arianna , Rabbone Ivana , Prodam Flavia , Bellone Simonetta

Background: The gastrointestinal (GI) tract plays a central role in maintaining energy balance and body weight regulation. These functions are mediated by the secretion of gut hormones, including ghrelin, cholecystokinin (CCK), peptide YY(PYY), oxyntomodulin (OXM) and many other hormones. Some of them are orexigenic hormones that promote food intake, while others act as satiety signals and enhance insulin secretion from the pancreatic beta cells. Current evide...

hrp0095p1-160 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Central diabetes insipidus following immunization with anti-COVID19 BNT162b2 Comirnaty vaccine

Partenope Cristina , Pedranzini Quincy , Petri Antonella , Prodam Flavia , Bellone Simonetta , Rabbone Ivana

Introduction: The coronavirus disease 19 (COVID19) pandemic urged to develop new vaccines to reduce the morbidity and mortality associated with this disease. Recognition and report of potential adverse effects of these novel vaccines (especially the urgent and life-threatening ones) is therefore essential.Case Presentation: A 16-year-old boy presented to the Paediatric Emergency Department with polyuria (9 liters per day...

hrp0095p1-360 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Somatostin analogs in a 15 year old boy with gigantism

Hernandez Claudia , Rodriguez Saa Magdalena , Fernandez Ivana , Figurelli Silvina , Daly Adrian , Guitelman Mirta

Introduction: Pituitary gigantism is caused by a somatotroph pituitary tumor that occurs before epiphyseal closure and is associated with increased morbidity due to the systemic effects of chronic hormonal excess. It is an extremely rare disease, with an estimated incidence of 8 per million person-years. Therapeutic modalities for pituitary gigantism are the same as those for acromegaly and include surgery, medication and radiation. Medical treatment plays an ...

hrp0082fc12.6 | Obesity | ESPE2014

Resveratrol Inhibits Inflammation-Induced Production of Cytokines in Human Adipocytes

Zagotta Ivana , Killian Alexandra , Haas Jennifer , Kietzmann Thomas , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Upon excessive expansion, adipose tissue is infiltrated by macrophages and shows increased production of inflammatory cytokines. This chronic low grade inflammation of adipose tissue is involved in the pathogenesis of insulin resistance. A supplementation with resveratrol can reverse the metabolic disturbances of human obesity, in part by mimicking the effects of caloric restriction.Objective and Hypotheses: We hypothesized that the beneficia...

hrp0082p2-d3-356 | Diabetes (2) | ESPE2014

Diabetic Ketoacidosis at the Onset of Type I Diabetes: a Retrospective Study in a Paediatric Population

Tuli Gerdi , Ignaccolo Giovanna Maria , Tinti Davide , Gioia Elisa , Sicignano Sabrina , Cerutti Franco , Rabbone Ivana

Background: There is wide geographic variation in the frequency of diabetic ketoacidosis (DKA) at onset of diabetes from ~15–70% in Europe and North America.Objective and hypotheses: To evaluate the frequency of DKA at the onset of type 1 diabetes (T1D) in the paediatric population seen in the Department of Pediatric Diabetology of Turin (Italy) from 1/1/2008 to 31/12/2013.Method: Data (venous pH and HCO3, season at the onset)...

hrp0084p3-1126 | Pituitary | ESPE2015

Outstanding Growth Response to Growth Hormone Replacement Therapy in 3 Different Cases of Growth Hormone Deficiency

Saranac Ljiljana , Djuric Zlatko , Markovic Ivana , Stamenkovic Hristina , Lazarevic Dragoljub , Cvetkovic Vesna

Background: Growth response in growth hormone deficient children during growth hormone (GH) replacement therapy rarely fulfil our projections and patient’s expectations. We here report 3 cases with outstanding growth response.Case reports: First patient was diagnosed as gluten enteropathy in early childhood, but the diet did not improve his growth. At age of 7 years the diagnosis of isolated growth hormone deficiency (GHD) was established and GH sub...

hrp0098p1-235 | Fat, Metabolism and Obesity 4 | ESPE2024

Towards a “Genetic Obesity Risk Score”: preliminary data from a single-centre cohort of obese children and adolescents

Partenope Cristina , Monteleone Giorgia , Rovellotti Matteo , Petri Antonella , Prodam Flavia , Bellone Simonetta , Rabbone Ivana

Background: Genetic factors play an important role in determining individual susceptibility to weight gain and obesity. In the last few years, several genetic variants have been identified as causative of monogenic/syndromic forms of obesity, mainly involved in the hypothalamic leptin-melanocortin pathways (LMP) that regulates food intake and energy homeostasis.Methods: Pediatric patients (<18 years) with severe obesi...

hrp0098p2-150 | GH and IGFs | ESPE2024

Real-world data on growth hormone therapy adherence using a connected injection device and catch-up growth in children with growth disorders in Serbia

Zdravkovic Vera , Vorgucin Ivana , Stankovic Sandra , Milenkovic Tatjana , Cvetkovic Zoran , Koledova Ekaterina , van Dommelen Paula

Background: Recombinant human growth hormone (r-hGH) therapy is an effective treatment strategy for children experiencing growth disorders. However, poor adherence to long-term r-hGH therapy can lead to suboptimal catch-up growth. Digital health solutions, such as easypod® connect ecosystem, can facilitate adherence to r-hGH therapy in these patients.Aim: To investigate the adherence to r-hGH therapy administered via...