hrp0084p2-329 | Fat | ESPE2015

Meteorin-Like (METRNL) Expression in Human Adipose Tissue is Associated with Adipocyte Hypertrophy and Inflammation and is Down-Regulated During Human Adipogenesis

Loffler Dennis , Rockstroh Denise , Schwartze Julian , Landgraf Kathrin , Korner Antje

Background: The new adipokine/myokine meteorin-like (Metrnl) has been proposed to be of interest for obesity and metabolic disease through its potential role for brown/beige fat thermogenesis and macrophage activation in mice. METRNL was reported to be expressed in white adipose tissue (AT) and upregulated during adipogenesis and by exercise and.Aims: In this study we analysed the expression of METRNL during human adipogenesis and its regulation...

hrp0092fc4.2 | Fat Metabolism and Obesity Session | ESPE2019

Characterization of the Adipose Progenitor Cell Marker MSCA1 in Normal Weight and Obese Children

Hanschkow Martha , Bouloumié Anne , Dietrich Arne , Kiess Wieland , Körner Antje , Landgraf Kathrin

Background: Obesity is characterized by an increase in fat mass caused by an increase in adipocyte number and adipocyte size and is often associated with adipose tissue (AT) dysfunction contributing to metabolic impairment. It is suspected that adipocyte progenitor cells play an important role during healthy and obesity-related AT expansion. Studies in adults showed that the stroma vascular fraction (SVF) of AT is composed of different progenitor cell subpopul...

hrp0089p1-p093 | Fat, Metabolism and Obesity P1 | ESPE2018

Functional Characterization of Novel and Known Genetic Variants in the Leptin Receptor (LEPR) Gene of Two Patients with Morbid Obesity

Voigtmann Franziska , Robert Stein , Landgraf Kathrin , Abou Jamra Rami , Kiess Wieland , Korner Antje

Background: The leptin signaling cascade is a crucial regulator of satiety and energy homeostasis in the hypothalamus, comprising extracellular leptin binding to its receptor, phosphorylation and nuclear translocation of STAT3 (signal transducer and activator of transcription 3) and consecutively the generation of a central satiety signal via neuropeptide secretion. We identified three variants in the extracellular domains of the LEPR gene in two children with severe ...

hrp0089p2-p142 | Fat, Metabolism and Obesity P2 | ESPE2018

Children with Obesity are Taller in Early Childhood with Subsequent Catch-down Growth Until Adolescence

Kempf Elena , Vogel Tim , Kratzsch Jurgen , Vogel Mandy , Landgraf Kathrin , Sergeyev Elena , Kiess Wieland , Stanik Juraj , Korner Antje

Context: Childhood obesity is supposed to affect growth and development in children but there is uncertainty with regard to dynamics and potential causes. We analyzed differences in age-related growth patterns of obese and normal-weight children and their association with circulating endocrine and metabolic factors.Objective/Design: In a large German childhood cohort from Leipzig including 7986 children (22793 data sets) we compared cross-sectional and l...

hrp0086p1-p445 | Fat Metabolism and Obesity P1 | ESPE2016

The Impact of Activating PIK3CA Mutations and PTEN Haploinsufficiency on Human Adipocyte Phenotype and Biology

Kassner Franziska , Handel Norman , Leipert Jenny , Sauer Tina , Wilhelm Franziska , Landgraf Kathrin , Kiess Wieland , Korner Antje , Garten Antje

Background: The phosphatase and tensin homolog (PTEN)/phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway is central for cell cycle control, differentiation, migration, and metabolism. Unrestricted growth of adipose tissue in particular is frequently seen in humans with germline PTEN and mosaic activating PIK3CA mutations, respectively.Objective and hypotheses: We assume that adipocytes from affected tissue show hyperproliferation and modified dif...