hrp0097rfc8.6 | Fat, metabolism and obesity 2 | ESPE2023

Leukocytes and Neutrophil–Lymphocyte Ratio as Indicators of decreased insulin sensitivity in NGT Overweight and Obese Children with high 1-hour post-load plasma glucose levels

Mastromauro Concetta , Lauriola Federico , Matonti Lorena , Trisi Giulia , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: Obese children with normal glucose tolerance (NGT) but with 1-hour post-load plasma glucose (1hPG) ≥ 132.5 mg/dl are at higher risk of developing type 2 diabetes (T2D) and cardiometabolic complications. In addition, new markers of systemic inflammation derived from blood cell count could be used as indicators of insulin resistance, thus predicting worse metabolic profile.Objective: The aim of our study w...

hrp0097p1-202 | Adrenals and HPA Axis | ESPE2023

Increased adiposity and insulin resistance negatively affect growth in pre-pubertal heterozygote carriers of 21-Hydroxylase deficiency

Mascioli Ilaria , Mastromauro Concetta , Lauriola Federico , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: 21-Hydroxylase deficiency (21-OHD) is the archetype of congenital adrenal hyperplasia (CAH). Deficiency of 21-Hydroxylase results in an impairment of cortisol synthesis, which is critical in stressful conditions when higher output is required to restore homeostasis. In addition, an increased androgen production, might results in undesirable manifestations of hyperandrogenism, as menstrual abnormalities, infertility and cosmetic annoyances and gro...

hrp0097p1-80 | Fat, Metabolism and Obesity | ESPE2023

Leukocyte, platelet counts and the neutrophil-to-lymphocyte ratio (NLR) are related to insulin resistance in obese and overweight children

Lauriola Federico , Mastromauro Concetta , Mascioli Ilaria , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Background and aims: The development of insulin resistance (IR) may be influenced by inflammation in overweight/obese individuals. To identify indicators of IR, new markers of inflammation and systemic inflammation such as leukocyte (WBC) and platelet counts (PLT), the neutrophil-to-lymphocyte ratio (NLR) have been suggested. This study aims to investigate the association between these markers and IR in a group of overweight and obese.<s...