hrp0084p2-287 | Diabetes | ESPE2015

Incidence of Type 1 Diabetes among Korean Children and Adolescents in 2012–2013: Analysis of Data from the Nationwide Registry of Korea

Kim Jae Hyun , Lee Young Ah , Yang Sei Won , Shin Choong Ho

Background: The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents has increased worldwide. However, the epidemiology of T1DM among Korean children has not been reported since 2001.Objective and hypotheses: We therefore investigated the incidence of T1DM in Korean children and adolescents in 2012–2013 and compared it with data from 1995–2000.Method: Data were obtained from the National Health Insuran...

hrp0089p1-p107 | Fat, Metabolism and Obesity P1 | ESPE2018

Serum Uric Acid Level and Its Association with Metabolic Syndrome in Korean Adolescents

Jung So Yoon , Lee Young Ah , Kim Jae Hyun , Lee Seong Yong , Kim Se Young , Shin Choong Ho , Yang Sei Won

Background: Elevated serum uric acid (UA) levels are associated with metabolic syndrome (MS), cardiometabolic risk factors (CMRFs) and non-alcoholic fatty liver disease (NAFLD) in adults. However, little is known about usefulness of UA to predict MS in adolescents. As the prevalence of obesity among pediatric population has been increasing, it is important to know the factors associated with the CMRFs to prevent future development of diabetes and cardiovascular disease.<p ...

hrp0089p3-p201 | GH &amp; IGFs P3 | ESPE2018

Effects on Near-adult Height and Safety of Recombinant Human Growth Hormone in Growth Hormone Deficiency and Turner Syndrome Patients: Results from the LG Growth Study

Choi Jin-Ho , Chung Sochung , Rhee Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Yoo Jae-ho , Lee Young Ah , Hwang Il Tae

Objectives: This study was performed to evaluate effectiveness on near-adult height (NAH) and safety of recombinant human growth hormone (rhGH) (Eutropin® Inj., Eutropin®Plus Inj., Eutropin®AQ Inj., LG Chem, Ltd.) treatment in children with growth hormone deficiency (GHD) and Turner syndrome (TS).Methods: The LG Growth Study (LGS) is a multicenter, long-term, observational study designed to evaluate the lon...

hrp0089p1-p262 | Thyroid P1 | ESPE2018

Subclinical Hypothyroidism, Thyroid Nodule or Cyst in Prepubertal Children: How Many Children were Diagnosed at Age 6?

Lee Young Ah , Cho Sun Wook , Lim Youn-Hee , Kim Johanna Inhyang , Kim Bung-Nyun , Hong Yun-Chul , Park Young Joo , Shin Choong Ho , Yang Sei Won

Purpose: We investigated the prevalence of subclinical hypothyroidism (SCH) and its risk factors in prepubertal children at age 6. We also evaluated the prevalence of thyroid nodule or cyst and its relationship with SCH in prepubertal children.Methods: From the Environment and Development of Children (EDC) cohort study, 458 prepubertal children (243 boys, mean 5.8 years) who visited at age 6 were included in this study. Serum concentrations of free thyro...

hrp0084p1-29 | Diabetes | ESPE2015

Is Reduced Heart Rate Variability Associated with Arterial Stiffness in Youth with Childhood-Onset Type 1 Diabetes Mellitus?

Kim Hwa Young , Jung Hae Woon , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: Increased arterial stiffness may precede cardiovascular complications in patients with type 1 diabetes (T1DM). As the autonomic nervous system is responsible for regulating heart rate and vascular tone, autonomic dysfunction may contribute to increased arterial stiffness in patients with T1DM.Objective and hypotheses: We investigated whether decreased heart rate variability (HRV) was associated arterial stiffness index (ASI) in patients with ...

hrp0084p1-139 | Turner &amp; Puberty | ESPE2015

A Study of Arterial Stiffness in Turner Syndrome Patients Using Cardio-Ankle Vascular Index

Jung Hae Woon , Kim Hwa Young , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: A large proportion of the increased mortality in Turner syndrome (TS) is related to cardiovascular complications. Increased arterial stiffness may be an important predictor related to cardiovascular complications. A novel method of evaluating arterial stiffness, relatively independent of changes in blood pressure (BP), is the cardio-ankle vascular index (CAVI).Objective and hypotheses: The aim of this study was to compare arterial stiffness u...

hrp0084p2-322 | DSD | ESPE2015

Clinical Spectrum of 45,X/46,XY Mosaicism and Variants in Children

Jung Hae Woon , Kim Hwa Young , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: The phenotypic manifestations in the 45,X/46,XY karyotype is diverse and there are challenges in management due to this diversity.Objective and hypotheses: The aim of this study was to describe the clinical spectrum of 45,X/46,XY mosaicism and variants diagnosed in childhood.Method: A retrospective review of 20 patients with 45,X/46,XY (n=7) and its variants ((45,X/46,X,der(Y) (n=12)) and 46,X,der(X),t...

hrp0084p2-331 | Fat | ESPE2015

Autonomic Nervous System Function Assessed by Heart Rate Variability in Children and Adolescents with Long Term Follow up of Craniopharyngioma

Jung Hae Woon , Kim Hwa Young , Lee Gyung Min , Kim So Youn , Jeong Kyung A , Choi Keun Hee , Lee Jieun , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: Obesity is a well-recognized complication of craniopharyngioma. Increased hypothalamic involvement (HI) by the tumour and accordant treatment has been associated with greater obesity. Changes in hypothalamic control of the autonomic nervous system (ANS) have been implicated in the development of hypothalamic obesity however, long term changes in the ANS have not been assessed.Objective and hypotheses: We aimed to evaluate ANS activity using h...

hrp0084p3-1086 | Perinatal | ESPE2015

Usefulness of ultrasonography for detecting adrenal haemorrhage in neonates with relative adrenal insufficiency

Jeong Kyung A , Kim Hwa Young , Jung Hae Woon , Kim So Youn , Choi Keun Hee , Lee Gyung Min , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: Relative adrenal insufficiency (RAI) may be associated with neonatal adrenal hemorrhage (AH).Objective and hypotheses: The purpose of this study was to investigate the usefulness of ultrasonography for detecting AH in steroid treated neonates with RAI.Method: A retrospective analysis of 52 corticosteroid-treated patients with RAI at a neonatal intensive care unit of a tertiary center from January 2006 to April 2014 was ...

hrp0084p3-1212 | Thyroid | ESPE2015

Goitre in Childhood and Adolescence; Clinical Course and Associated Factors for Thyroid Autoimmunity or Isolated Nonautoimmune Hyperthyrotropinemia

Kim So Youn , Jung Hae Woon , Jeong Kyung A , Choi Keun Hee , Lee Gyung Min , Kim Hwa Young , Lee Young Ah , Shin Choong Ho , Yang Sei Won

Background: Simple goitre (SG) and autoimmune thyroid disease (AITD) are the two most common causes of goiter in children.Objective and hypotheses: The prevalence of thyroid dysfunction, AITD, and SG at the time of goiter diagnosis was investigated. The natural course of SG was studied and factors related to the development of AITD and/or thyroid dysfunction were analysed.Method: A retrospective review of 1,225 patients (1071 femal...