hrp0095p1-281 | Fat, Metabolism and Obesity | ESPE2022

Impact of Covid-19 pandemic on the efficacy of outpatient counseling in childhood obesity management.

Corica Domenico , Li Pomi Alessandra , Curatola Selenia , Pepe Giorgia , Tropeano Angelo , Aversa Tommaso , Wasniewska Malgorzata

Introduction: The Covid-19 pandemic drastically modified social life and lifestyle in particular among children and adolescents, promoting sedentary behaviors and unhealthy eating habits. In this scenario, the effectiveness of the outpatient approach for pediatric obesity may decrease.Objectives: Aims of this study were to assess the rate and the factors associated with outpatient drop-out by comparing two groups of chil...

hrp0092p2-147 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

A Rare Cause of Pediatric Hypoglycemia in a Boy: A Malignat Insulinoma

Valenzise Mariella , Zirilli Giuseppina , Cannavo' Laura , Passanisi Stefano , Li Pomi Alessandra , Wasniewska Malgorzata

Insulinoma is a rare neuroendocrine tumor, usually benign, but can be life-threatening in causing hypoglycemic accidents. It presents in individuals aged between 8 and 82 years and can occur sporadically or constitute a part of multiple endocrine neoplasia type 1 (MEN-1).The nonspecific-symptoms and small size of these tumors led to difficulties of diagnosis and localization.Here we describe the case of a 11-year-old boy, who came to our attention for a ...

hrp0095rfc11.2 | Late Breaking | ESPE2022

Dynamics of meal-related plasma asprosin levels

Corica Domenico , Pepe Giorgia , Aversa Tommaso , Currò Monica , Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Ientile Riccardo , Wasniewska Malgorzata

Background: Asprosin is an adipokine involved in glucose homeostasis and its plasma levels physiologically increases in fasting conditions and decreases with refeeding. In non-diabetic children and adolescents with obesity, insulin resistance (IR) and impaired fasting glucose (IFG) seem to influence the physiological variation in meal-related asprosin levels 120 minutes after an oral glucose load (Corica et al. doi:10.3389/fendo.2021.805700). No data ...

hrp0095t20 | Section | ESPE2022

Sensitivity to thyroid hormones and cardiometabolic risk in euthyroid obese children: a cross-sectional study.

Tropeano Angelo , Corica Domenico , Lorenza Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Pepe Giorgia , Aversa Tommaso , Wasniewska Malgorzata

Background: The typical biochemical phenotype related to obesity, that is high serum thyrotropin (TSH) within normal range, low/normal free thyroxine (FT4) and increased free triiodothyronine (FT3) levels, can be interpreted as a resistance to thyroid hormones. It is unclear the role played by thyroid hormones in the pathogenesis of metabolic derangement associated with obesity.Aim: To investigate the association between...

hrp0097p2-10 | Growth and Syndromes | ESPE2023

Overgrowth in a 12-years-old boy with distal chromosome 16 duplication syndrome

Abbate Tiziana , Aversa Tommaso , Briuglia Silvana , Pepe Giorgia , Li Pomi Alessandra , Moschella Antonino , Paola Capra Anna , Wasniewska Malgorzata , Corica Domenico

Background: Distal chromosome 16 duplication syndrome, also known as 16q partial trisomy, is a very rare genetic disorder. Smaller chromosomal copy number variants (CNVs) within the 16q region create partial trisomies, which occur less frequently than full trisomy 16q. Trisomy 16q is generally associated with a multisystemic phenotype including intrauterine growth restriction (IUGR), brain and cardiac defects, intellectual disability and an increased risk of b...

hrp0097p2-37 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

A male case of peripheral precocious puberty caused by testotoxicosis

Coco Roberto , Pepe Giorgia , Li Pomi Alessandra , Corica Domenico , Lugarà Cecilia , Valenzise Mariella , Wasniewska Malgorzata , Aversa Tommaso

Introduction: Familial male-limited precocious puberty (or testotoxicosis) is a very rare genetic disorder with autosomal dominant transmission that causes gonadotropin-independent precocious puberty due to mutations activating the lutropin-chorionic gonadotropin receptor (LHCGR), which lead to elevated testosterone levels and suppressed gonadotropins. The age of onset is between 2-5 years essentially with penis and testes enlargement, linear growth accelerati...

hrp0094p2-462 | Thyroid | ESPE2021

Growth impairment in children with severe autoimmune primary hypothyroidism and pituitary hyperplasia without goiter

Corica Domenico , Kucharska Anna Malgorzata , Vierucci Francesco , Valenzise Mariella , Li Pomi Alessandra , Tuli Gerdi , Munarin Jessica , Pyrzak Beata , Cesaretti Graziano , Aversa Tommaso , Wasniewska Malgorzata

Background: Prolonged severe hypothyroidism due to Hashimoto’s thyroiditis (HT) is a rare cause of pituitary hyperplasia (PH) in children. Loss of thyroxine negative feedback causes a TRH-dependent hyperplasia of pituitary thyrotroph cells resulting in adenohypophysis enlargement. A transdifferentiation of pituitary somatotroph cells into thyrotroph cells could explain growth failure in those patients. We report a case series of patients with growth impairment diagnosed...

hrp0097p1-382 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

A new GATA-4 mutation in a child with disorder of sex development and central precocious puberty

Luppino Giovanni , Corica Domenico , Valenzise Mariella , Briguglia Silvana , Bertelloni Silvano , Li Pomi Alessandra , Wasniewska Malgorzata , Aversa Tommaso , Christian Denzer , Martin Wabitsch

Background: Disorders of sex development (DSD) are often due to disruption of the genetic programs that regulate gonad development. Some genes have been identified in these developmental pathways such as DAX-1, SOX-9, GATA-4 and others. The GATA-4 gene, located on chromosome 8p23.1, encodes GATA-binding protein 4 (GATA-4), a transcription factor that is essential for cardiac and gonadal development and sexual differentiation. Congenital heart disease (CHD) and...