hrp0092p2-147 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

A Rare Cause of Pediatric Hypoglycemia in a Boy: A Malignat Insulinoma

Valenzise Mariella , Zirilli Giuseppina , Cannavo' Laura , Passanisi Stefano , Li Pomi Alessandra , Wasniewska Malgorzata

Insulinoma is a rare neuroendocrine tumor, usually benign, but can be life-threatening in causing hypoglycemic accidents. It presents in individuals aged between 8 and 82 years and can occur sporadically or constitute a part of multiple endocrine neoplasia type 1 (MEN-1).The nonspecific-symptoms and small size of these tumors led to difficulties of diagnosis and localization.Here we describe the case of a 11-year-old boy, who came to our attention for a ...

hrp0095p1-281 | Fat, Metabolism and Obesity | ESPE2022

Impact of Covid-19 pandemic on the efficacy of outpatient counseling in childhood obesity management.

Corica Domenico , Li Pomi Alessandra , Curatola Selenia , Pepe Giorgia , Tropeano Angelo , Aversa Tommaso , Wasniewska Malgorzata

Introduction: The Covid-19 pandemic drastically modified social life and lifestyle in particular among children and adolescents, promoting sedentary behaviors and unhealthy eating habits. In this scenario, the effectiveness of the outpatient approach for pediatric obesity may decrease.Objectives: Aims of this study were to assess the rate and the factors associated with outpatient drop-out by comparing two groups of chil...

hrp0095rfc11.2 | Late Breaking | ESPE2022

Dynamics of meal-related plasma asprosin levels

Corica Domenico , Pepe Giorgia , Aversa Tommaso , Currò Monica , Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Ientile Riccardo , Wasniewska Malgorzata

Background: Asprosin is an adipokine involved in glucose homeostasis and its plasma levels physiologically increases in fasting conditions and decreases with refeeding. In non-diabetic children and adolescents with obesity, insulin resistance (IR) and impaired fasting glucose (IFG) seem to influence the physiological variation in meal-related asprosin levels 120 minutes after an oral glucose load (Corica et al. doi:10.3389/fendo.2021.805700). No data ...

hrp0095t20 | Section | ESPE2022

Sensitivity to thyroid hormones and cardiometabolic risk in euthyroid obese children: a cross-sectional study.

Tropeano Angelo , Corica Domenico , Lorenza Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Pepe Giorgia , Aversa Tommaso , Wasniewska Malgorzata

Background: The typical biochemical phenotype related to obesity, that is high serum thyrotropin (TSH) within normal range, low/normal free thyroxine (FT4) and increased free triiodothyronine (FT3) levels, can be interpreted as a resistance to thyroid hormones. It is unclear the role played by thyroid hormones in the pathogenesis of metabolic derangement associated with obesity.Aim: To investigate the association between...

hrp0094p2-462 | Thyroid | ESPE2021

Growth impairment in children with severe autoimmune primary hypothyroidism and pituitary hyperplasia without goiter

Corica Domenico , Kucharska Anna Malgorzata , Vierucci Francesco , Valenzise Mariella , Li Pomi Alessandra , Tuli Gerdi , Munarin Jessica , Pyrzak Beata , Cesaretti Graziano , Aversa Tommaso , Wasniewska Malgorzata

Background: Prolonged severe hypothyroidism due to Hashimoto’s thyroiditis (HT) is a rare cause of pituitary hyperplasia (PH) in children. Loss of thyroxine negative feedback causes a TRH-dependent hyperplasia of pituitary thyrotroph cells resulting in adenohypophysis enlargement. A transdifferentiation of pituitary somatotroph cells into thyrotroph cells could explain growth failure in those patients. We report a case series of patients with growth impairment diagnosed...