hrp0089p3-p333 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

Young Male Adolescent with Gender Dysphoria (GD)/Gender Incongruence – A Case Presentation

Vlachopapadopoulou Elpis-Athina , Dikaiakou Eirini , Karagianni Stavroula , Michalacos Stefanos

Background: Children and adolescents who have a gender identity that does not correlate with their assigned gender (based upon genital anatomy and chromosomes) are described as Gender-Dysphoric/Gender-Incongruent Persons (GD/gender incongruence) based on the ICD-11 classification of the World Health Organization.Objective: The case of a young teenager with Gender Dysphoria Disorder.Case presentation: A boy, aged 13 and 4/12 years, ...

hrp0082p3-d1-906 | Pituitary | ESPE2014

Pituitary Dysfunctiona with Associated Lesions in the Hypothalamo-Pituitary Region: Histiocytosis or Dysgerminoma?

Vlachopapadopoulou Elpis , Papadakis Vassilios , Nomikos Panagiotis , Michalacos Stefanos , Polychronopoulou Sophia

Background: Patients who present with clinical and laboratory findings of pituitary dysfunction and whose MRI findings reveal increased pituitary size or thickening of pituitary stalk, pose a diagnostic challenge. The differential diagnosis mainly includes dysgerminoma, histiocytosis, and hypophysitis. A non-invasive approach is often non-diagnostic.Objective and hypotheses: To present two patients with similar clinical picture and positive MRI findings,...

hrp0095p1-13 | Adrenals and HPA Axis | ESPE2022

Clinical characteristics and pubertal development in Greek girls with premature adrenarche.

Athina Vlachopapadopoulou Elpis , Dikaiakou Eirini , Kosteria Ioanna , Athanasouli Fani , Kafetzi Maria , Michalacos Stefanos

Background: Premature adrenarche (PA) is characterized by the appearance of pubic and axillary hair associated with an increase in adrenal androgen production, in the absence of central puberty, steroidogenic enzyme defects, or virilizing tumors, before the age of 8 years in girls and 9 years in boys. Studies have shown increased likelihood of PA for children with obesity and those born small for gestational age (SGA).Aim:</stron...

hrp0092p1-96 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Assessment of Subjective and Objective Compliance to Growth Hormone Therapy of Children with Growth Hormone Deficiency

Vlachopapadopoulou Elpis Athina , Drosatou Chrysoula , Kaloumenou Eirini , Gerali Maria , Michalacos Stefanos

Introduction: The success of rhGH therapy is thought to be dependent on the patient's ability to maximally adhere to their treatment regimen.Aim: To compare the reported (subjective) compliance as it was documented via a questionnaire fulfilled by the parents and/or patients, with actual (objective) compliance as recorded by a delivery device, to rhGH therapy.Material and Methods</stron...

hrp0092p1-432 | Thyroid (2) | ESPE2019

Levothyroxine Effect on Thyroid Volume in Children with Autoimmune Hashimoto Thyroiditis (AHT) Presenting Subclinical (SH) or Overt (Oh) Hypothyroidism

Leka-Emiri Sofia , Petrou Vassilios , Evangelopoulou Cathrine , Vakaki Marina , Fotinou Aspasia , Vlachopapadopoulou Elpis , Michalacos Stefanos

Objectives: Assess thyroid volume in relation to TSH and FT4 at diagnosis of AHT and 2.9 years of follow up in children with SH or OH.Methods: wo hundred one children (155 girls) with AHT were divided according to TSH and FT4 levels [SH-FT4 >1.0 ng/dl: Group 1: TSH: 5-7.5 mU/l, Group 2: TSH: >7.5 mU/l, OH: Group 3: TSH>7.5 mU/l and FT4 ≤1.0ng/dl]. Mean L-T4 dose is reported in µg/Kg/day. Thyroid...

hrp0092p2-251 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

3β-HSD2 Deficiency Due to Compound Heterozygosity of a Missense Mutation (p.Thr259Met) and a Frameshift Deletion (p.Lys273ArgFs*7) in an Under-Virilized Infant Male with Salt Wasting

Leka-Emiri Sofia , Taibi Ludmia , Fotinou Aspasia , Vlachopapadopoulou Elpis , Michalacos Stefanos , de Roux Nicolas

Objectives: To describe clinical, hormonal and genetic findings of an under-virilized infant male, 13 month old, of afghani origin, presented at the emergency department with salt-wasting adrenal crisis.Case report: The patient, a 13 month old male infant, presented at the emergency department with complaints of vomiting and fever. Physical examination was significant for severe dehydration along with perineal hypospadia...

hrp0092p3-126 | Fat, Metabolism and Obesity | ESPE2019

Metabolic Risk Assessment in Obese Children Using Hypertriglyceridemic Waist (HTGW) Phenotype. Can it be a Useful Screening Marker?

Dikaiakou Eirni , Vlachopapadopoulou Elpis-Athina , Athanasouli Fani , Stergiotis Stefanos , Kafetzi Maria , Fotinou Aspasia , Michalacos Stefanos

Background: The prevalence of childhood obesity is dramatically increasing worldwide. Overweight and obesity are well known risk factors for metabolic disorders such as Insulin Resistance, Type II Diabetes, Arterial Hypertension and Non Alcoholic Fatty Liver Disease (NAFLD).Aims: This study was conducted to assess the prevalence of Hypertriglyceridemic Waist phenotype (HTGW) among overweight and obese Greek children. Fur...

hrp0089p2-p222 | GH &amp; IGFs P2 | ESPE2018

Height Perception of Children with GH Deficiency: Influencing Factors and Links to Psychosocial Functioning

Drosatou Chrysoula , Vlachopapadopoulou Elpis-Athina , Bullinger Monika , Quitmann Julia , Silva Neuza , Michalacos Stefanos , Tsoumakas Konstantinos

Objectives: The aims of this study were: (1) to evaluate the perception of children with GH Deficiency (GHD) and their parents, regarding their current and future predicted height, as well as the modulating factors; (2) to investigate the relation between perceptions of height and psychosocial functioning in children with GHD.Methods: The study group consists of 322 children/adolescents (219 boys) diagnosed with (isolated) GHD, treated with GH. The mean ...

hrp0089p2-p224 | GH &amp; IGFs P2 | ESPE2018

Factors Influencing Health Related Quality of Life in Children/Adolescents with GH Deficiency

Drosatou Chrysoula , Vlachopapadopoulou Elpis-Athina , Quitmann Julia , Bullinger Monika , Silva Neuza , Michalacos Stefanos , Tsoumakas Konstantinos

Objectives: To describe the Health Related Quality of life (HrQoL) of children/adolescents with GH Deficiency (GHD) and to examine the effects of sociodemographic (i.e., patients’ age, sex and family socioeconomic status) and clinical characteristics (i.e. degree of short stature and duration of treatment) on HrQoL from patients’ and their parents’ perspectives. Associations between QoLISSY questionnaire and demographics were evaluated using Mann-Whitney or Krus...

hrp0089p3-p259 | Growth &amp; Syndromes P3 | ESPE2018

17p13.1 Microduplication Syndrome in a Child with Familial Short Stature and GH Deficiency: A Short Case Report

Leka-Emiri Sofia , Petrou Vassilios , Manolakos Emmanouil , Fotinou Aspasia , Thomaidis Loretta , Vlachopapadopoulou Elpis , Michalacos Stefanos

Background: To date, six cases of 17p13.1 microduplications have been described in the literature. Intellectual disability is the core feature, together with minor facial dysmorphisms and obesity later in life, but a characteristic phenotype for 17p13.1 microduplication has not been delineated.Objective and hypothesis: We describe a young patient with a 422 Kb microduplication maternally inherited in 17p13.1, affected by mild intellectual disability and ...