hrp0086p2-p766 | Pituitary and Neuroendocrinology P2 | ESPE2016

Congenital Craniopharyngioma: Report of Two Cases

Bogusz Agnieszka , Moszczynska Elzbieta , Szalecki Mieczyslaw

Introduction: Craniopharyngiomas are slow growing epithelial tumors located in the sellar or suprasellar region of the brain. Adamantinomatous subtype affects mainly children and accounts for 5–10% of all intracranial paediatric tumors. Diagnosed antenatal and neonatal craniopharyngiomas are very seldom, about 40 such cases have been detected to date. They are characterised by large size, progressive hydrocephalus and a poor prognosis.Aim: The aim o...

hrp0084p3-1125 | Pituitary | ESPE2015

Combined Pituitary Hormone Deficiency

Kot Karolina , Moszczynska Elzbieta , Szalecki Mieczyslaw

Background: Combined pituitary hormone deficiency (CPHD) may be congenital or acquired disorder, which affects more than one hormonal axis. Congenital hipopituitarism includes heterogenic group of disturbances. It may be result of mutations or deletions in genes for signaling and transcription factors responsible for pituitary development. The disorder might affect one or multiple family members. The age of appearance and intensity of the first hormone deficiency symptoms may ...

hrp0086p1-p746 | Pituitary and Neuroendocrinology P1 | ESPE2016

Prognostic Significance of the Proliferative Index Ki67 for Patients with Craniopharyngiomas

Moszczynska Elzbieta , Bogusz Agnieszka , Szymanska Sylwia , Grajkowska Wieslawa , Szalecki Mieczyslaw

Background: Craniopharyngioma is a benign, slow-growing epithelial tumor, in children it contributes to 5–10% of all brain tumors. Its incidence is 0.5-2 per 1,000,000 person-years. 30–50% of these tumors are recognized in childhood, most often in ages 5–14, no sex predilection is observed. It is located mainly in the sellar/parasellar region, in children adamantinomatous variant, with tendency to recur, is the most common type. Views on the usefulness of immuno...

hrp0084p3-815 | Endocrine Oncology | ESPE2015

Craniopharyngioma – Symptoms, Treatment and Follow Up – An Analysis of 100 Cases

Moszczynska Elzbieta , Bogusz Agnieszka , Bendysz-Golatowska Anna , Szalecki Mieczyslaw

Background: Craniopharyngiomas are rare embryogenic malformations of the sellar area with low-grade histological malignancy. Its incidence is 0.5–2.0 cases per million persons per year, 30–50% of all cases become apparent in children.Objective and hypotheses: The aim of the study was to analyse the clinical symptoms and treatment efficacy in children diagnosed with Craniopharyngioma.Method: A retrospective analysis includ...

hrp0084p3-853 | Fat | ESPE2015

Nonalcoholic Steatohepatitis Leading to Cirrhosis of the Liver as a Complication of Hypothalamic Disorders in a Course of Craniopharyngioma – Case Report

Watrobinska Urszula , Bendysz-Golatowska Anna , Moszczynska Elzbieta , Szalecki Mieczyslaw

Background: Craniopharyngioma is low – grade malignant tumour with high survival rate. Its incidence is 0.5–2.0 cases per million persons per year. 30–50% of all cases occur in the childhood. The tumour location leads to numerous complications like deficits of pituitary function, impairment of vision, neuropsychological deficits and obesity. Excess body fat is observed in 40–50% of craniopharyngioma patients.Case presentation: We pres...

hrp0086p2-p54 | Adrenal P2 | ESPE2016

Hyperandrogenism in a 12-year Old Girl with a Congenital Porto-Systemic Shunt and Congenital Hepatic Fibrosis

Danko Mikolaj , Kot Karolina , Szalecki Mieczysław , Moszczynska Elzbieta , Malinowska Anna

Background: Hyperandrogenism in children is associated with excessive adrenal or gonadal androgens secretion. The most common causes of androgens hypersecretion are PCOS, adrenal tumors, Cushing’s syndrome, CAH, and gonadal virilizing tumors. Within the last 15 years single case-reports of hyperandrogenism in female patients with congenital porto-systemic shunts were described in literature. The mechanism of such coincidence is unknown but the role of hyperinsulinism, imp...