ESPE Abstracts

Background: Thyroid imaging is recommended to determine the aetiology of congenital hypothyroidism (CHT). Currently scintigraphy is the gold standard imaging modality. Negative scinitigraphy despite the presence of thyroid tissue may lead to a spurious diagnosis of athyreosis. Few centres routinely perform both scinitgraphy and ultrasound so that the incidence of misclassified athyreosis is unknown.Aim: To describe the incidence of sonographically normal...

Background: Mild isolated neonatal hyperthyrotropinaemia (HTT), defined as elevated thyroid stimulating hormone (TSH) with normal free thyroxine (FT4) concentrations, may be identified by newborn screening programmes for congenital hypothyroidism (CHT) or when neonatal thyroid function tests (TFTs) are performed for a clinical indication. Reported HTT incidence rates vary (from 0.001-0.1%)1. Case definition also varies, with some authors using a TSH...

Background: Hyperthyrotropinaemia (HTT) describes the biochemical condition of elevated thyroid stimulating hormone (TSH) with normal thyroid hormone concentration. The aetiology of this condition is likely multifactorial but factors such as maternal thyroid disease and presence of trisomy 21 (T21) are thought to play an important role. HTT can be identified during newborn screening for congenital hypothyroidism (CHT), or when thyroid investigations are perfor...