hrp0092p1-256 | Pituitary, Neuroendocrinology and Puberty (1) | ESPE2019

Kisspeptin Levels is a New Diagnostic Approach of Hypogonadotropic Hypogonadism in Boys

Nikitina Irina , Yukhlina Yulya , Nagornaya Irena , Kelmanson Igor , Grineva Elena

Background: In hypogonadotropic hypogonadism (HH), hypophyseal follicle-stimulating and luteinizing hormones, normally released with GnRH stimulation, are detected low. Since kisspeptin (KP) is a strong stimulant of GnRH neurons, it is considered to have a role in HH aetiology. It may be hypothesized that abnormal plasma levels of KP are indicative of HH.Aim: Evaluation and comparison of plasma KP levels in boys of pre-p...

hrp0089fc13.5 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2018

Study of the Serum Kisspeptin Level in Healthy and Hypogonadotropic Boys

Nikitina Irina , Khoduleva Yulia , Nagornaya Irena , Vasileva Elena

Background: Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as key players of the gonadotropic axis. It was found that KiSS-1/GPR54 system plays an important role in the neuroendocrine control of gonadotropin secretion, brain sex differentiation, puberty onset and fertility. It is important to know if the kisspeptin serum level could be used as a diagnostic criterion to the stage of puberty or impairment of it in ...

hrp0089p3-p171 | Fetal, Neonatal Endocrinology and Metabolism P3 | ESPE2018

Comparison of Metabolic Parameters of Children’s Blood Depending on the Level of Mother’s Glycemia During Pregnancy

Masel Alisa , Kaprior Ekaterina , Polyanskaya Alexandra , Nikitina Irina

Introduction: The impact of gestational diabetes mellitus (GDM) on fetal development and the future health of the child need further studying. In accordance to the criteria by Hyperglycemia and Adverse Pregnancy Outcome Study, GDM can lead to a number of negative consequences, including the impact on disturbance of metabolic parameters.Aim: To compare the impact of glycemia during pregnancy on the childrenÂ’s metabolic status.M...

hrp0082p2-d2-602 | Thyroid (1) | ESPE2014

Influence of Amiodarone on Thyroid Function in Children

Nikitina Irina , Vasichkina Elena , Artemeva Irina , Liskina Anastasia , Lebedev Dmitri

Background: Unlike to adults, the side effects of long-term administration by amiodarone (A) of life-threatening arrhythmias (LThA) on thyroid function still is not studied exactly in children.Methods: Twenty-six children with LThA aged 1 week to 16 years (mean 10 years) treated by A were examined. The mean duration of oral treatment ranged from 1 month to 47 months (mean 12.5 months). We estimated serum level of T4, T3, TSH, antibo...

hrp0094p1-42 | Sex Endocrinology and Gonads A | ESPE2021

Disorders of sex development: clinical and genetic heterogeneity

Nikitina Irina , Kudryashova Elena , Sarakaeva Leyla , Kostareva Anna ,

Background and Aims: Disorders of sex development (DSD) are a group of rare congenital conditions. Clinical management of patients with DSD is often difficult and requires multidisciplinary approach.Material and methods: Twenty-eight patients aged 1 to 18 years with different forms of 46, XY DSD were included. The subjects have undergone a clinical examination, karyotype analysis followed by the next generation sequencing (NGS) using MiS...

hrp0086p2-p412 | Gonads & DSD P2 | ESPE2016

Towards the Roles of Kisspeptins in the Control of Gonadotropic Axis: Focus on Peripheral Signaling in Androgen-Dependent Tissues in the Experimentally Induced Model Hypogonadotropic Hypogonadism in Male Rats

Nikitina Irina , Khoduleva Yulia , Nagornaya Irina , Bairamov Alekber , Shabanov Petr , Masel Alisa

Background: Recently kisspeptins are considered as a key gatekeepers of the regulation of the gonadotropic axis.Objective and hypotheses: To investigate the impact of experimentally induced hypogonadism on kisspeptins signaling in androgen-dependent tissues and blood.Method: Wistar male rats (29 in total) were used. Rats were divided into four groups. Group 1 (control, prepubertal rats aged 2 months, n=7). Group 2 (control...

hrp0094fc7.6 | Fetal Endocrinology and Multisystem Disorders | ESPE2021

Reassessment of 18F-DOPA PET cut-offs in congenital hyperinsulinism

Gubaeva Diliara , Ryzhkova Daria , Nikitina Irina , Mitrofanova Lubov , Tiulpakov Anatoly , Melikyan Maria ,

Introduction: Congenital hyperinsulinism (CHI) is a rare but severe condition causing persistent hypoglycaemia. Approximately 30-40% of patients require surgical treatment. Extent of surgery depends on the histological form of the disease: subtotal pancreatectomy is done in diffuse CHI, whereas pancreatic resection is recommended in focal CHI.18F-DOPA PET scan is a gold-standard imaging technique that helps in differential diagnosis of diffuse and f...

hrp0095p1-237 | Diabetes and Insulin | ESPE2022

Neurodevelopmental outcomes in children with congenital hyperinsulinism.

Nikitina Irina , Sarakaeva Leyla , Eftich Egine , Bairov Vladimir , Sukhotskaya Anna , Smorodin Andrey , Ryzhkova Darya , Mitrofanova Lubov , Kelmanson Igor

Background: Congenital hyperinsulinism (CHI) is a rare group of genetic disorders resulting in persistent hypoglycemia which can lead to a considerable risk of neurological damage and developmental delay.Aim: To assess the neurodevelopmental outcome in children with CHI.Methods: Thirty-three patients with СHI aged from 7 to 58 months were included. All subjects underwent clinic...