hrp0086fc11.5 | Thyroid | ESPE2016

Pediatric Reference Values of Thyrotropin (TSH) should be Personalized According to Child Characteristics

Meyerovitch Joseph , Feldhamer Ilan , Manor Mira , Oron Tal

Background: Primary care pediatricians (PCPs) use thyroid function tests (TFT) as screening tests in children and adolescents with various health complaints. Thus, it is crucial to evaluate the results according to appropriate cut-offs individualized to the child characteristics. Such references values, which are missing in the pediatric age group, are needed for proper evaluation of the thyroid functions.Objective and hypotheses: To determine normal TSH...

hrp0095p2-53 | Diabetes and Insulin | ESPE2022

Clinical and immunological characteristics of new-onset type 1 diabetes in children during the COVID-19 pandemic

Gil Margolis Merav , Weizman Sarit , Lazar Liora , Yakobovich-Gavan Michal , Tenenbaum Ariel , Phillip Moshe , Oron Tal

Background: Type 1 Diabetes (T1D) is a chronic disease resulting from autoimmune destruction of insulin-secreting pancreatic β cells. Viruses are known to play a role in the pathogenesis of T1D. There is no consistent evidence that SARS-CoV-2 induces T1D in children or adults. Nevertheless, evidence suggests that the SARS-CoV-2 affects β cell function, suggesting a role for the virus in the pathogenesis of the disease. It is thus plausible that the e...

hrp0089p1-p041 | Diabetes & Insulin P1 | ESPE2018

Concealment of Type 1 Diabetes in Adolescence Affects Adherence to Treatment, Metabolic Control, and Quality of Life

Nir Judith , Leffler Nir , Nagelberg Nessia , Yacobovitz-Gavan Michal , Phillip Moshe , Oron Tal

Introduction: Type 1 diabetes (T1D) is one of the common chronic diseases of childhood. T1D management is affected both by physiological and behavioral factors. Some patients and their parents choose to conceal the disease from others. Concealment of disease status is not unique for T1D, and has been shown to adversely affect clinical outcomes, social support and well-being of patients with other chronic conditions. There is limited data on the effects of concealment of T1D in...

hrp0084p3-1182 | Thyroid | ESPE2015

The Role of Early Thyroid Imaging in Children with Congenital Hypothyroidism

Oron Tal , Lebenthal Yael , Ben-Yishai Shimon , Tenenbaum Ariel , Yackobovitch-Gavan Michal , Phillip Moshe , Lazar Liora

Background: Congenital hypothyroidism (CH) occurs in 1:3000–1:4000 newborns. The majority of newborns with CH are detected by routine screening programs and treatment is promptly initiated following confirmatory thyroid function testing. Although early imaging studies do not influence the treatment decision or management, they establish the underlying diagnosis and may distinguish between permanent and transient CH.Objective: To assess the role of e...

hrp0094p1-171 | Growth Hormone and IGFs B | ESPE2021

Diagnosing growth hormone deficiency - Can a combined arginine and clonidine stimulation test replace two separate tests?

Oron Tal , Krieger Avihu , Yakobovich-Gavan Michal , Tenenbaum Ariel , Diamant Rotem , Phillip Moshe , Lazar Liora ,

Objective: Given a large number of false-positive growth hormone deficiency (GHD) diagnoses from a single GH stimulation test in normal children, two different pharmacological tests, performed on separate days or sequentially, are required. This study aims to assess the reliability and safety of a combined clonidine-arginine stimulation test (CACST).Design: Retrospective, single-center, observational study....

hrp0084p1-44 | Diabetes | ESPE2015

Is Metabolic Control Affected by Military Service in Young Adults with Type 1 Diabetes?

Brener Avivit , Mel Eran , Shalitin Shlomit , Lazar Liora , de Vries Liat , Tenebaum Ariel , Oron Tal , Philip Moshe , Lebenthal Yael

Background: Young adults with type 1 diabetes (T1D) are exempt from conscript military service due to risk of severe hypoglycaemia and metabolic compromise. Nevertheless, there are patients who volunteer to military service.Aims and objectives: To evaluate the effect of military service on metabolic control and incidence of acute diabetes complications.Methods: Study design: retrospective, comparative analysis. Data of 145 T1D pati...

hrp0097p1-492 | GH and IGFs | ESPE2023

GH stimulation testing: is it time to change the paradigm?

Smuel Keren , Lazar Liora , Yackobovitch-Gavan Michal , Tirosh Liron , Phillip Moshe , Oron Tal , Sarah Flanagan , Jayne Houghton

Background: The efficacy of growth hormone (GH) treatment in short, healthy children diagnosed with growth hormone deficiency (GHD) or those meeting the criteria of idiopathic short stature (ISS) suggest that an overlap exists between these two conditions. Although flawed and inconsistent, growth hormone stimulation tests (GHST) are the key diagnostic tool differentiating between GHD and ISS affecting clinical decisions such as treatment eligibility and dose.<...

hrp0095fc8.2 | Diabetes and Insulin | ESPE2022

Detection of anti-islet antibodies in capillary blood by the antibody detection by agglutination-PCR (ADAP) technology is sensitive and suitable for general population screening programs

Oron Tal , de Jesus Cortez Felipe , Shtaif Biana , Robinson Peter V. , Yackobovitch-Gavan Michal , Seftel David , Phillip Moshe , Tsai Cheng-ting , Gat-Yablonsky Galia

Background: Detection of type 1 diabetes (T1D) at the pre-clinical stage is possible by detecting islet autoantibodies (IA) years before the appearance of symptomatic diabetes. An efficient screening program based on these antibodies will identify children at risk of developing diabetes during childhood. The antibody detection Israeli research (ADIR) is a general population screening program in Israel searching for children with multiple IA who are at risk of ...

hrp0092t17 | Top 20 Poster | ESPE2019

Factors Associated with Dyslipidemia in Patients with Type 1 Diabetes: A Single-Center Experience

Volsky Sari Krepel , Shalitin Shlomit , Yackobovitch-Gavan Michal , Lazar Liora , Bello Rachel , Oron Tal , Tenenbaum Ariel , de Vries Liat , Phillip Moshe , Lebenthal Yael

Background: Type 1 diabetes (T1D) contributes to altered lipid profiles and increased cardiovascular disease (CVD) risk. Youth with T1D may have subclinical CVD within the first decade of diagnosis.Objective: To assess risk factors associated with dyslipidemia in young subjects with T1D.Study Design and Methods: A longitudinal and cross-sectional retrospective cohort study was cond...