ESPE Abstracts

Background: Decreased serum 25-hydroxyvitamin D (25-OHD) level has frequently been reported in obesity, a condition which is associated with insulin resistance. Insulin resistance was negatively associated with serum 25-OHD. Puberty is the period with altered insulin sensitivity. Previous studies showed conflicting results of the variation of serum 25-OHD levels across pubertal stages. However, data on serum 25-OHD levels across pubertal stages in obese childr...

Background: Subcutaneous gonadotropin-releasing hormone (GnRH) analog test is an alternative to standard intravenous GnRH test for diagnosing central precocious puberty (CPP). Previous studies showed different cutoffs of basal and peak serum LH levels following intravenous GnRH and subcutaneous GnRH analog for diagnosing CPP girls. However, no study that defined the discriminating basal and peak LH levels among CPP and premature thelarche (PT) girls with different breast Tanne...

Background: Elevated serum luteinizing hormone (LH) during gonadotropin-releasing hormone (GnRH) test is documented in girls with central precocious puberty (CPP). Lower LH secretion has been reported in obese girls as compared with lean girls. Few studies have addressed the effect of obesity on peak serum LH levels during GnRH test. This study aimed to determine peak serum LH levels during GnRH analog (GnRHa) test in CPP girls of different body mass index (BM...

Background: The neuropeptide kisspeptin has recently been demonstrated to play a role in regulating energy balance and glucose metabolism. Previous studies showed a positive effect of serum kisspeptin in relation to glucose metabolism. These included negative association between serum kisspeptin and body mass index (BMI), homeostatic model assessment of insulin resistance (HOMA-IR) and plasma insulin. However, some studies reported conflicting results. Data on...

Neonatal severe primary hyperparathyroidism (NSHPT) is a rare and life-threatening disorder caused by inactivating mutation in CASR gene, which encodes Ca-sensing receptor. NSHPT leads to severe neonatal hypercalcemia with inappropriately increased serum intact parathyroid hormone (iPTH) and decreased urinary Ca excretion. Hydration, forced diuresis, calcitonin, bisphosphonates and cinacalcet have been used to lower serum Ca prior to surgery. Total parathyroidectomy i...

Background: Pediatric acute lymphoblastic leukemia survivors (pALL-S) carry a risk for developing metabolic abnormalities, including obesity, abnormal glucose metabolism (AGM) and dyslipidemia. Previous studies showed conflicting data regarding the pathophysiology of AGM in those survivors. Additionally, there has never been a study comparing glucose metabolism between pALL-S and simple obese children (Ob-C). This study aimed to assess glucose metabolism in pA...