hrp0089fc14.5 | Multisystem Endocrine Disorders | ESPE2018

Pubertal Females Produce an Enhanced Interferon-Alpha, Anti-viral Response Compared to Males, Which is Associated with X Chromosome Number, and Not Sex Hormones

Webb Kate , Butler Gary , Ciurtin Coziana , Peckham Hannah , Radziszewska Anna , Wedderburn Lucy R , Ioannou John

Introduction: Very little is known about the development of the immune system during puberty. Autoimmune diseases, like juvenile onset systemic lupus erythematosus (jSLE), have an unexplained female bias and a higher incidence after puberty. IFN alpha (IFNα) is a potent antiviral cytokine, and jSLE has a strong IFNα transcriptional signature. Toll like receptors 7 and 9 (TLR7/9) sense viral RNA and DNA respectively, and trigger plasmacytoid dendritic cells (pDC) to p...

hrp0089fc14.6 | Multisystem Endocrine Disorders | ESPE2018

Sex Differences in Autoimmune Disease: Testosterone is Associated with a Decrease in Expression of Key Anti-viral Genes During Puberty, Which may Decrease the Risk of Autoimmunity in Males

Webb Kate , Butler Gary , Ciurtin Coziana , Peckham Hannah , Radziszewska Anna , Wedderburn Lucy R , Ioannou Yiannis

Introduction: There are well described sex differences in the immune system. It has been shown in both innate and adaptive immunity that females have a more robust response than males. Various autoimmune diseases have a strong sex bias towards females. It is the accepted dogma that oestrogen in females relates to an increased risk of autoimmunity, but evidence to this end is scarce. Interferon alpha (IFNα) is a potent anti-viral innate cytokine, and many autoimmune diseas...

hrp0094p1-32 | Fat, Metabolism and Obesity A | ESPE2021

Sex hormones drive changes in lipoprotein profiles in adolescents; early implications for cardiovascular disease risk

Robinson George , Peng Junjie , Peckham Hannah , Radziszewska Anna , Butler Gary , Pineda-Torra Ines , Jury Elizabeth , Ciurtin Coziana ,

Prior to menopause, it is known that women have a lower risk of cardiovascular disease (CVD) and coronary heart disease compared to age-matched men; it is reported that women have around half the CVD risk and almost a 10-year delay in first myocardial infarction event compared to men. Sex differences in serum lipids could contribute to CVD risk through driving atherosclerosis, the buildup of lipids in the sub-endothelial intimal layer of medium-sized to large arteries. We hypo...

hrp0094fc5.2 | Sex Development and Gender Incongruence | ESPE2021

Unexpected impact of sex hormones on B-cells in trans- and cis-gendered healthy young people

Peckham Hannah , Rosser Elizabeth C , Radziszewska Anna , Robinson George , Martin-Gutierrez Lucia , De Gruijter Nina M , Jury Elizabeth C , Butler Gary E , Ciurtin Coziana ,

Background: Cis-gender females are known to mount stronger immune responses to invading pathogens or vaccines than cis-gender males. However, this is also associated with increased risk of autoimmunity. Little is known about the immunophenotypes of transgender individuals on gender-affirming hormonal treatment, despite growing evidence that hormones influence the immune system. Via the process of class-switch recombination (CSR), B-cell immunoglobulin isotype ...