hrp0089p1-p245 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Thyroid Function in Central Precocious Puberty Girls

Rhie Young-Jun , Nam Hyo-Kyoung , Lee Kee-Hyoung

Objectives: Obesity is a well-known risk factor for central precocious puberty (CPP). Recently, elevated thyroid stimulating hormone (TSH) were reported in obese youth. However, few data regarding the relationship between CPP and TSH are available. The aim of this study was to evaluate thyroid function in CPP girls and the relationship between CPP and serum TSH concentration.Methods: This is a retrospective cross-sectional study. A total 1,247 girls aged...

hrp0092p1-268 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

Idiopathic Scoliosis in Girls with Central Precocious Puberty: Incidence and Effect of Gonadotropin-Releasing Hormone Agonists

Chung Lindsey Yoojin , Nam Hyo-Kyoung , Rhie Young-Jun , Huh Rimm , Lee Kee-Hyoung

Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis, affecting approximately 2 to 4 percent of adolescents. AIS by definition occurs in children between 10 to 18 years old, in periods of growth spurts and puberty changes. In patients with central precocious puberty (CPP), generally, growth spurts start earlier than their peers. Therefore, AIS in patients with CPP is expected to develop earlier in juvenile age. Especially in girls, both AIS and CPP are mo...

hrp0092lb-15 | Late Breaking Posters | ESPE2019

Efficacy of 3-Monthly Compare to Monthly Depot GnRH Agonist (Triptorelin Pamoate) in the Treatment of Girls with Central Precocious Puberty in Korea

Yoojin Chung Lindsey , Huh Rimm , Nam Hyo-Kyoung , Rhie Young-Jun , Lee Kee-Hyoung

Background: Triptorelin depot is largely used to treat central precocious puberty (CPP) in children and currently 3 monthly depot was introduced. No Korean data are available on 3-monthly GnRH agonist treatment in central precocious puberty.Aim: To compare the efficacy of Triptorelin 11.25mg 3-months depot with 3.75mg monthly depot in suppressing pubertal development from the beginning to 6 month and 1 year after the tre...

hrp0092p2-283 | Thyroid | ESPE2019

Changes of Thyroid Function in Girls with Central Precocious Puberty After 6-Month GnRH Agonist Treatment

Huh Rimm , Yoojin Chung Lindsey , Nam Hyo-Kyoung , Rhie Young-Jun , Lee Kee-Hyoung

Objectives: In our previous study, serum thyroid stimulating hormone (TSH) level in the central precocious puberty (CPP) group was higher than that of the non-CPP group. Serum free thyroxine (fT4) level in the CPP group was notably lower than that of the non-CPP group. And it was also showed that age and peak luteinizing hormone (LH) were independent predictors of serum TSH concentration. Elevated TSH in girls with CPP is supposed to be associated with puberta...

hrp0092p3-123 | Fat, Metabolism and Obesity | ESPE2019

Validity of Non-High-Density Lipoprotein Cholesterol for Detecting Dyslipidemia Among Korean Adolescents

Nam Hyo-Kyoung , Yoojin Lindsey , Huh Rimm , Rhie Young-Jun , Lee Kee-Hyoung

Objectives: Non-high-density lipoprotein (HDL) cholesterol is an alternative method to assess dyslipidemia and is not required fasting. We aimed to assess the validity of non-HDL cholesterol for detecting dyslipidemia among Korean adolescents.Subjects and Methods: Data for 6,989 adolescents aged 10 to 19 years (3,684 boys and 3,305 girls), were obtained from the Korean National Health and Nutrition Examination Surveys du...

hrp0086p1-p741 | Pituitary and Neuroendocrinology P1 | ESPE2016

Serum Anti-Mullerian Hormone Levels in Precocious Puberty Girls According to the Timing of GnRH Agonist Treatment

Nam Hyo-Kyoung , Kim Hye Ryun , Rhie Young Jun , Lee Kee-Hyoung

Background: Few studies have investigated the long-term effects of gonadotropin releasing hormone (GnRH) agonist treatment on reproductive function.Objective and hypotheses: We assessed ovarian function by analyzing serum anti-mullerian hormone (AMH) levels in central precocious puberty (CPP) girls according to GnRH agonist-treatment timing.Method: Our study included 505 CPP girls subdivided into five groups based on the timing of ...

hrp0086p2-p838 | Syndromes: Mechanisms and Management P2 | ESPE2016

A Novel Fibrillin-1 Gene Mutation Leading to Marfan Syndrome in Korean Girl

Nam Hyo-Kyoung , Nam Myung-Hyun , Rhie Young-Jun , Lee Kee-Hyoung

Background: Marfan syndrome is one of the most common over-growth conditions and the cardinal features occur in ocular, skeletal and cardiovascular systems. Clinical variation is common and signs are age-dependent.Case: A 9-year-old girl was referred to our pediatric endocrinology clinic for tall stature. Physical examination revealed a lens dislocation with strabismus, high palate, positive wrist and thumb signs, joint hypermobility, and pes plenus. Dil...

hrp0084p3-706 | Diabetes | ESPE2015

Hearing Changes in Children and Adolescents with Type 1 Diabetes Mellitus

Rhie Young-Jun , Baek Joon Woo , Nam Hyo-Kyoung , Lee Kee-Hyoung

Background: There have been reports that patients with diabetes have hearing loss greater than those without. Suggested pathogenesis for diabetes-associated hearing loss has included cochlear microangiopathy, hyperglycaemia of cerebrospinal fluid, auditory neuropathy and diabetic encephalopathy.Objective and hypotheses: This study is aimed to investigate hearing changes in children and adolescents with type 1 diabetes mellitus and to examine if hearing c...

hrp0084p3-833 | Fat | ESPE2015

Correlation of Serum FGF-21 Levels with Metabolic Parameters in Korean Obese Children

Baek Joonwoo , Nam Hyo-Kyoung , Rhie Young-Jun , Lee Kee-Hyoung

Background: Serum FGF-21 levels are increased in adults with obesity, type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Serum FGF-21 levels have been implicated as a potential biomarker for early detection of the metabolic syndrome (MetS) and type 2 diabetes in adults. However, there are only a few studies about the correlation between FGF-21 levels and metabolic parameters in children.Aims and objective: This study is aimed to evaluate the r...

hrp0084p3-1142 | Puberty | ESPE2015

Qualitative Assessment of Precocious Puberty-Related UCC (User Created Contents) on YouTube

Nam Hyo-Kyoung , Bang Soo Min , Baek Joon Woo , Rhie Young-Jun , Lee Kee-Hyoung

Background: Precocious puberty is one of the fastest-growing paediatric diseases in South Korea. As the UCC (User Created Contents) has provided lots of medical information, it becomes an easy and important source of medical information.Objective and hypotheses: This study aimed to investigate and to evaluate the quality and scientific accuracy of precocious puberty-related UCC on Youtube.Method: The key words ‘precocious pube...