hrp0082p2-d2-384 | Fat Metabolism & Obesity (1) | ESPE2014

Ambulatory Arterial Stiffness Index in Obese Children

Saner Christoph , Mullis Primus , Simonetti Giacomo , Janner Marco

Background: Altered arterial stiffness is a recognized risk factor of poor cardiovascularhealth. Ambulatory arterial stiffness index (AASI, defined as one minus the regression slope of diastolic on systolic blood pressure values derived from a 24 h arterial blood pressure monitoring (ABPM)) is an upcoming and readily available marker of arterial stiffness. We tested the hypothesis that AASI is increased in obese children compared to healthy subjects.Meth...

hrp0084p2-343 | Fat | ESPE2015

Chronodisruption in Obese Children

Saner Christoph , Mullis Primus , Simonetti Giacomo D , Janner Marco

Background: Altered circadian and ultradian blood pressure (BP) and heart rate (HR) rhythmicity has been described in many diseases with increased cardiovascular risk.Objective and hypotheses: We tested the hypothesis that rhythmicity in obese children is changed, compared to healthy subjects.Method: Circadian and ultradian BP and HR rhythmicity was assessed with Fourier analysis from 24-h ambulatory BP measurement (ABPM) in 75 obe...

hrp0097p1-514 | Growth and Syndromes | ESPE2023

Addition of genetic workup in children with isolated short stature to improve the diagnostic yield for growth hormone treatment

Martinez de Lapiscina Idoia , Zürcher Matthias , Saner Christoph , E. Flück Christa

Introduction: Short stature is a common finding that affects per definition about 3% of the population. Isolated, severe short stature may be treated successfully with recombinant human growth hormone (rhGH). Currently, rhGH is offered to short children with specific disorders or biochemically proven growth hormone deficiency (GHD). However, biochemical testing for GHD is artificial and therefore controversial. Adding genetic testing may improve the diagnostic...