hrp0095p1-380 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Effect of Long Acting Gonadotropin Releasing Hormone Agonists on Height Outcome in Children

Sahmoud Shaimaa , Gupta Sanjay , Greetham Sandra

Gonadotropin releasing hormone agonists (GnRHa) stops premature sexual maturation in young children and preserve the potential of achieving acceptable adult height.Aim: To assess the efficacy of long acting GnRHa in suppressing early pubertal development and its impact on height outcome in our patient population.Methods: Records of children treated with GnRHa since 2018 at Hull University Hospital;...

hrp0084p3-691 | Diabetes | ESPE2015

Acute Kidney Injury as a Severe Complication of Diabetic Ketoacidosis

Jeyaraman Alagusutha , Finlay Eric , Mathew Verghese , Gupta Sanjay

Background: Diabetic ketoacidosis (DKA) in children and young adults carries significant morbidity and mortality relating to complications such as cerebral oedema. Acute kidney injury (AKI) is a rare but potentially fatal complication of DKA. We present three cases of DKA complicated by AKI.Case 1: A 9-year-old girl presented with severe DKA at diagnosis. She was treated with intravenous fluids and insulin as per protocol. She had oliguria and haematuria...

hrp0084p3-1141 | Puberty | ESPE2015

Does Treatment with GnRH Analogues Affect BMI in Children with Precocious or Early Puberty?

Madhusudhana Madhavi , Willingham Linda , Gupta Sanjay , Matthew Verghese

Background: Treatment of precocious puberty with GnRH analogues is well established. But there are concerns about weight gain in patients on this treatment. There have been conflicting reports about the effect of GnRH analogues on weight.Objective and hypotheses: To assess the change in BMI in children treated with GnRH analogues within a UK Endocrine Service and to analyse the patient/parent experience of the treatment.Method: A r...

hrp0084p3-1224 | Thyroid | ESPE2015

Transient Polyarthritis with Carbimazole Treatment

Madhusudhana Madhavi , Barraclough Mary , Baguley Elaine , Gupta Sanjay

Background: Antithyroid drugs such as carbimazole form the mainstay of medical management of hyperthyroidism in children. Parents are always warned about agranulocytosis, which is a rare side effect of these drugs. Development of arthralgia after starting antithyroid medication can be a disabling side effect and needs to be distinguished from the more serious antineutrophil cytoplasmic antibody (ANCA) positive vasculitis.Objective and hypotheses: Here we...

hrp0097p1-246 | Fat, Metabolism and Obesity | ESPE2023

Obesity Caused by Mutations in the Melanocortin 4 Pathway: Experience From a Teaching Hospital

Gupta Sanjay , Dalpathadu Sanjalee , Mathew Verghese , Greetham Sandra

Introduction: The role of genetics in obesity is a much under discussed area. Whilst it is undeniable that environmental factors play a major role in obesity in most cases, there is a small proportion of cases where genetic mutations are the main underlying cause. This includes novel monogenic conditions involving mutations in the Melanocortin-4 receptor (MC4R) signalling pathway. In a healthy individual, the post-meal increase in leptin (LEP) stimulates melan...

hrp0097p1-96 | GH and IGFs | ESPE2023

Modified Insulin Stress Test for Assessment of Growth Hormone Secretion – Experience from a University Teaching Hospital

Gupta Sanjay , Dean Olivia , Mathew Verghese , Tharian Kavitha , Willingham Linda

Introduction: Insulin stress test (IST) to diagnose growth hormone (GH) deficiency is rarely used by paediatric endocrine teams in the United Kingdom, due to concerns over safety. We share our experience of undertaking modified IST in children, with regards to safety and outcomes.Methods: We adapted the protocol for insulin stress test, proposed by Galloway et al to undertake pituitary stimulation test for our c...

hrp0097p1-561 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Copeptin as a reliable marker in differentiating Nephrogenic Diabetes Insipidus (NDI) and Central Diabetes Insipidus (CDI)-a case study

Spilioti Diamantina-Xanthi , Minett Gemma , Rowland-Hill Chris , Douglas Linda , Gupta Sanjay

Introduction: Arginine vasopressin (AVP) and thirst are the main determinants of water homeostasis maintenance, and dysregulation leads to polyuria-polydipsia syndrome. This comprises of three key conditions: CDI due to insufficiently secreted AVP; NDI, due to renal AVP insensitivity and Primary Polydipsia (PP), caused by excessive fluid intake resulting in physiological suppression of AVP. Differentiating between these three conditions is important, as the tr...