hrp0092p1-407 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

No Association Between Serum Level of NPTX 1 and MKRN3 in Central Precocious Puberty

Rim Jeong Hwal , Tae Hwang Il

Abstract: Background: Makorin ring finger protein 3 (MKRN3) is most common genetic cause of central precocious puberty (CPP) and associated with the initiation of puberty. Although its actual function is veiled. Recent study reported MKRN3 interacted with and suppressed neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in mice.Objective: The aim of this study was t...

hrp0089p2-p231 | GH & IGFs P2 | ESPE2018

Relationship between Growth Velocity and Change of Serum Insulin-Like Growth Factor-1 (IGF-1), Serum IGF Binding Protein-3 (IGFBP-3) Concentrations, and IGFBP-3 Promoter Polymorphism during Gonadotropin-Releasing Hormone Agonist (GnRHa) Treatment

Yang Seung , Suk Shim Young , Tae Hwang Il

Purpose: This study aims to investigate the effect of GnRHa on GH-IGF-1 axis and to evaluate if −202 A/C IGFBP-3 promoter polymorphism affects the growth velocity during treatment on girls with central precocious puberty (CPP).Methods: Data was collected from 97 girls, diagnosed under 9 year of age and treated by GnRHa for at least 1 year in Kangdong Sacred Heart Hospital between 2014–2015. Their body height, weight, Δ Height standard dev...

hrp0095p1-63 | Fat, Metabolism and Obesity | ESPE2022

Association of transient elastography and ultrasonographic fatty liver indicator in pediatric non-alcoholic steatohepatitis

Seo Yoon Jong , Tae Hwang Il , Young Kim Eun

Background: Transient elastography (TE) uses pulsed echo ultrasound to measure the hardness of the liver, showing excellent accuracy in the assessment of fibrosis, and is considered a useful test in nonalcoholic fatty liver disease (NAFLD). Ultrasound fatty liver indicator (US-FLI) is proposed as a non-invasive, semi-quantitative method for predicting hepatitis in children with NAFLD and may reflect the severity of liver histological changes. US-FLI ≥4 or 6...

hrp0095p1-264 | Fat, Metabolism and Obesity | ESPE2022

Triglyceride–glucose–alanine aminotransferase index as a novel and superior predictor for non-alcoholic fatty liver disease in children and adolescents

Seo Yoon Jong , Gyeol Kim Bit , Tae Hwang Il

Background: Insulin resistance, non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS) are strongly correlated with each other. Triglyceride and glucose (TyG) index, a simple and useful insulin resistance surrogate marker, has recently been reported to be superior in predicting NAFLD in adults.Objects: We evaluated the usefulness of TyG–alanine aminotransferase (ALT) for detecting NAFLD and compar...

hrp0095p1-464 | Fat, Metabolism and Obesity | ESPE2022

Triglyceride glucose index is associated with the severity of ultrasonographic fatty liver indicator in pediatric non-alcoholic steatohepatitis

Gyeol Kim Bit , Seo Yoon Jong , Tae Hwang Il

Background: Triglyceride glucose (TyG) index is known as a reliable insulin resistance surrogate marker to identify non-alcoholic fatty liver disease (NAFLD). Ultrasound fatty liver indicator (US-FLI) is proposed as a non-invasive, semi-quantitative method for predicting hepatitis in children with NAFLD and may reflect the severity of liver histological changes. US-FLI ≥4 has been suggested as a predictive finding for severe NASH. US-FLI correlates signific...

hrp0095p1-469 | Fat, Metabolism and Obesity | ESPE2022

Triglyceride-glucose-alanine aminotransferase index is associated with the severity of transient elastography in pediatric non-alcoholic steatohepatitis

Seo Yoon Jong , Tae Hwang Il , Hee Yi Kyung

Background: The triglyceride glucose (TyG) index is significantly associated with the presence of nonalcoholic fatty liver disease (NAFLD) and is a reliable insulin resistance (IR) surrogate marker. Alanine aminotransferase (ALT) has been commonly used to reflect liver inflammation and liver damage in patients with chronic liver diseases, including NAFLD. Transient elastography (TE) uses pulsed echo ultrasound to measure the hardness of the liver, showing exce...

hrp0095p1-543 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Klotho response to treatment with GnRH agonist in children with central precocious puberty

Seo Yoon Jong , Bit Gyeol Kim , Tae Hwang Il

Background: Klotho is an anti-aging protein acting as a circulating hormone. Major physiologic activities attributed to klotho include regulation of phosphate and calcium homeostasis, aging, adipogenesis, and glucose metabolism. Pubertal children had higher klotho than prepubertal. Insulin like growth factor-1 (IGF-1) directly promotes klotho shedding. Klotho levels significantly correlated with IGF-1 standard deviation scores (SDS).<str...

hrp0086p1-p484 | Fat Metabolism and Obesity P1 | ESPE2016

Fetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children

Joung Oh Yeon , Hee Yi Kyung , Jae Kang Min , Woo Baek Joon , Yang Seung , Tae Hwang Il

Background: Fetuin-A plays a role in insulin resistance and cardiovascular disease.Objective and hypotheses: The aim of present study was to determine the relation between fetuin-A levels and caridiometabolic risk factors and to investigate effect of serum fetuin-A to insulin sensitivity indices for determining whether fetuin-A is additional marker of insulin resistance in prepubertal children.Method: Ninety-nine prepubertal Korean...

hrp0092lb-23 | Late Breaking Posters | ESPE2019

Long-Term Safety and Effectiveness of Recombinant Human Growth Hormone in Korean Pediatric Patients with Growth Disorders: 7-year Interim Analysis from LG Growth Study

Ah Lee Young , Chung Sochung , Rhie Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Yoo Jae-ho , Ho Choi Jin , Tae Hwang Il

Objectives: This study aimed to evaluate the long-term safety and effectiveness of recombinant human growth hormone (rhGH) (Eutropin® Inj.., Eutropin®Pen Inj., Eutropin®AQ Inj., and Eutropin®Plus Inj., LG Chem, Ltd.) based on the interim analysis of a 7-year accumulated data of the LG Growth Study (LGS) in Korean pediatric patients with growth disorders including growth hormone deficiency (GHD), T...

hrp0095p1-499 | GH and IGFs | ESPE2022

Long-term safety and effectiveness of recombinant human growth Hormone inKorean pediatric patients with growth disorders: 9-year interim analysis fromLG Growth Study

Kim Yoo-Mi , Chung Sochung , Rhie Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Ho Choi Jin , Ah Lee Young , Sang Lee Hae , Tae Hwang Il

This study aimed to evaluate the long-term safety and effectiveness of recombinant human growth hormone (rhGH; Eutropin®, Eutropin®Pen, Eutropin®AQ, and Eutropin®Plus, LG Chem, Ltd.) treatment in Korean pediatric patients. This observational study has been conducted since 2011, and the data were collected up to August 2021 for interim analysis. The incidence rates of all adverse events (AEs) were assessed for safety a...