hrp0084p1-47 | Diabetes | ESPE2015

Relative Hypoaldosteronism in a Patient with WOLCOTT-Rallison Syndrome

Ucar Ahmet , Aydemir Yusuf , Dogan Ayse , Tuncez Ebru

Background: Wolcott–Rallison syndrome (WRS) is an autosomal recessive, multi-system disorder with early onset diabetes in infancy. It is associated with clinical features that show variability between WRS cases. Clinical data are still scarce.Patient data: A 9 year old girl followed-up due to diabetes and growth failure since 2 months of age from another centre presented with ketoacidosis and multi-organ failure. After resolution of her decompansate...

hrp0082p1-d1-199 | Reproduction | ESPE2014

Associations of Vascular Biomarkers and the Somatotrophic Axis with Carotid Ultrasound and Echocardiography Findings in Relation to Turner Arteriopathy

Ucar Ahmet , Oz Fahrettin , Bas Firdevs , Oflaz Huseyin , Nisli Kemal , Tugrul Melike , Darendeliler Feyza , Saka Nurcin , Poyrazoglu Sukran , Bundak Ruveyde

Background: Turner syndrome (TS) is associated with increased arterial stiffness. To date, factors associated with the ontogeny of Turner arteriopathy remain unclear.Objective and hypotheses: To assess the associations of vascular biomarkers and the somatotrophic axis with arterial stiffness indices, and left heart size, in normotensive ‘dipper’ TS.Method: Sixty-one patients with uncomplicated normotentensive &#1...

hrp0094p1-38 | Fat, Metabolism and Obesity A | ESPE2021

Are Serum Spexin Levels Associated With Metabolic Syndrome Antecedents In Obese Adolescents?

Gulderen Kalay Şenturk Nida , Cakır Aydilek Dağdeviren , Yıldırmak Zeynep Yıldız , Ucar Ahmet ,

Objective: Spexin is a novel peptide implicated in food intake and satiety. Spexin levels are reduced in obese patients.Aim: To evaluate the associations of metabolic syndrome (metS) antecedents with serum spexin levels in obese adolescents.Setting: A university- based tertiary care centre.Patients and methods: Eighty consecutive obese adolescents aged 10-18 y and 80 healthy ...

hrp0086p1-p11 | Adrenal P1 | ESPE2016

Evaluation of the Glucocorticoid, Mineralocorticoid, and Adrenal Androgen Secretion Dynamics in A Large Cohort of Patients Aged 6–18 Years with Transfusion-dependent β-Thalassemia Major, with an Emphasis on the Impact of Cardiac Iron Load

Ucar Ahmet , Oner Nergiz , Ozek Gulcihan , Cetincakmak Mehmet Guli , Abuhandan Mahmut , Yildirim Ali , Kaya Cemil , Unverdi Sena , Emeksiz Hamdi Cihan , Yilmaz Yasin , Yetim Aylin

Background: The variable presence of adrenal insufficiency (AI) due to hypocortisolemia (HC) in patients with thalassemia is well established; however, the prevalence of adrenocortical hypofunction (ACH) in the zona glomerulosa and zona reticularis of the adrenal cortex is unknown.Objective and hypotheses: To establish the prevalence of ACH, we examined the cortisol response to 1 μg- and 250 μg- ACTH tests, plasma aldosterone (A)/plasma renin a...

hrp0086p2-p721 | Endocrinology and Multisystemic Diseases P2 | ESPE2016

Stanazolol Abuse: Diagnostic Dilemma in an Adolescent with Persistent Hypoglycemia

Ucar Ahmet , Yetim Aylin , Battal Muharrem , Pinarli Ferda Alparslan , Kilic Evrim , Tuncel Deniz , Ozturk Feyza Yener , Kaya Reyhan , Oral Arzu , Genc Ozgur

Background: Multiple endocrine neoplasia (MEN)1 is a rare autosomal dominant disorder with primary hyperparathyroidism, enteropancreatic neuroendocrine tumors and anterior pituitary adenomas.Patient: A16-yr-old male was referred to our center due to recurrent seizures. Family history was significant for maternal death due to metastatic adenocarcinoma of the lung,paternal history of low-grade liposarcomas and nephrolitiasis. Physical examination was norma...

hrp0095p1-396 | Thyroid | ESPE2022

A rare cause of acquired von Willebrand factor deficiency: Primary hypothyroidism due to autoimmune thyroiditis

Dağdeviren Çakır Aydilek , Yıldız Yıldırmak Zeynep , Eren Simge , Mısırlı Özdemir Ebru , Özdemir Mustafa , Ucar Ahmet

In children, autoimmune thyroiditis is often diagnosed with signs and symptoms such as goiter, short stature, and constipation. Delayed diagnosis of hypothyroidism may result in atypical signs and symptoms at presentation, depending on the severity of hypothyroidism. Von Willebrand disease (vWD) is the most common bleeding disorder caused by the quantitative or qualitative deficiency of von Willebrand factor (vWF). Acquired vWD (avWD) is a disorder characterized by low levels ...

hrp0084p1-144 | Miscelleaneous | ESPE2015

Primary Adrenal Insufficiency in Children without Congenital Adrenal Hyperplasia: Molecular and Clinical Characterisation of a Nationwide Cohort

Guran Tulay , Buonocore Federica , Saka Nurcin , Ozbek Mehmet Nuri , Aycan Zehra , Bereket Abdullah , Bas Firdevs , Darcan Sukran , Bideci Aysun , Turan Serap , Guven Ayla , Tarim Omer , Agladioglu Sebahat Yilmaz , Atay Zeynep , Ozen Samim , Demir Korcan , Akinci Aysehan , Aydin Banu Kucukemre , Buyukinan Muammer , Yuksel Bilgin , Yildiz Metin , Akcay Teoman , Kara Cengiz , Ozgen Tolga , Catli Gonul , Isik Emregul , Bolu Semih , Ozhan Bayram , Gurbuz Fatih , Ucar Ahmet , Demirbilek Huseyin , Abali Zehra Yavas , Doger Esra , Eren Erdal , Berberoglu Merih , Hacihamdioglu Bulent , Achermann John C.

Background: Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that requires accurate diagnosis and urgent treatment. Congenital adrenal hyperplasia is the most common cause of PAI in children. Non-CAH causes of PAI are relatively rare. Although several molecular causes have been found, it is emerging that considerable overlap in the clinical and biochemical features of these conditions exists.Objective and hypotheses: We inv...