hrp0095p2-207 | Multisystem Endocrine Disorders | ESPE2022

Bisphenol A (BPA): A Hidden Enemy

Grau Gema , Andrade Fernando , Vela Amaya , López Oceja Raquel , Rica Itxaso

Introduction: Endocrino disruptors (EDs) are substances that interfere with hormonal function. The long list of EDs includes multiple natural compounds and numerous synthetic chemicals such as bisphenol A (BPA). BPA is present in plastics used in common products (Packaging, bottles, toys, digital media, etc). Several studies have shown its ability to alter the regulation of developmentally relevant genes, inhibit the synthesis of sex hormones and induce the pr...

hrp0094p2-203 | Fat, metabolism and obesity | ESPE2021

Anthropometric and clinical situation in two groups of young adults born Small for Gestational Age (a group with catch-up and another without catch-up and treated with Growth Hormone)

Vela Amaya , Gonzalez Maria Regina , Diaz Cristina , Elorza Amaia , Grau Gema , Rodriguez Amaya , Rica Itxaso ,

Introduction: Children with Small for Gestational Age (SGA) are known to have lower neurocognitive development and an increased in cardiovascular risk in adulthood. 10% of SGA don´t usually do the catch-up and if they meet criteria they have indication to follow Growth Hormone (GH) treatment.Objectives: To establish the difference between SGA diagnosed children who did or did not catch-up (treated with GH), in terms...

hrp0097p2-215 | Adrenals and HPA Axis | ESPE2023

Pseudocushing. an exceptional patology in pediatrics

Vela Amaya , Grau Gema , Bermejo Marta , Miguel Vazquez , Garrido Marta , Rica Itxaso

Introduction: PseudoCushing is an unusual pathology. Among adults several cases have been published, however, in paediatrics it is unusual.Objective: Description of a PseudoCushing case from a patient admitted in a hospital and results from a study to discard secondary hypercortisolism due to stress.Patients and methods: 13 years old patient that it is admitted in hospital due to v...

hrp0097p2-115 | GH and IGFs | ESPE2023

Are there sex differences among patients to whom a growth hormone (GH) test with clonidina stimulus was required during the study of short stature?

Vela Amaya , GarcÍA Maria , Izquierdo Jon , Ugeso Alberto , Grau Gema , Rica Itxaso

Introduction: GH stimulus test is usually performed in pacientes With short stature and/or growth delayed study if GH deficit is suspected. Several articles concluded that male are more frequently diagnosed and treated of GH deficiency than femaleObjectives: To know gender's ratio and the possible anthropometric differences between patients that required a consult for short stature and to whom a stimulus test was pe...

hrp0089p3-p400 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

Clinical and Molecular Characterization of One Nr5a1 Gene Mutation Found in a Patient WITH 46, XY DSD

Vela Amaya , Lapiscina Idoia Martinez De , Nanclares Gustavo Perez De , Amaia Rodriguez , Rica Itxaso , Castano Luis , Grau Gema

Introduction: Steroidogenic factor-1 (SF1), encoded by the NR5A1 gene, regulates several genes involved in male sexual determination, such as SOX9 and AMH, cholesterol mobilization and synthesis of a number of steroidogenic enzymes, like 3╬▓HSD, and androgen biosynthesis, like INSL3. Mutations in NR5A1 have been associated to a broad phenotypic spectrum in 46, XY subjects, including pure gonadal dysgenesis, infertility, anorchia...