ESPE Abstracts

Background: Inhaled corticosteroids (ICS) and montelukast are commonly prescribed drugs in asthma treatment. Several studies have investigated the adverse effects of ICS on growth and weight gain in children. However, the biosafety studies of montelukast are mostly focused on the neuropsychiatric side effects. The present study aimed at investigating the adverse effects of montelukast and ICS on anthropometric parameters in children.Methods: The present ...

Aims: To define the normal ranges of the thicknesses of the skin and subcutaneous tissues via ultrasonography, and to determine whether the current syringe needle-lengths used for the subcutaneous injections were appropriate.Methods: The thicknesses of the skin and subcutaneous tissues of 2 244 students were measured at the left arm using ultrasonography. Patients were divided into three groups based on age: 6–8, 9–12 and 13–17 ye...

Background: Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder characterized by susceptibility to tumours including haemangioblastomas of retina and central nervous system, renal cell carcinoma and phaeochromocytomas. The disease is caused by mutations in the VHL tumour suppressor gene.Objective and hypotheses: We present an adolescent with VHL disease confirmed by genetic analysis which revealed the mutation p. A149P (PCC>GCC), which ...

Objective: To determine the prevalences of goitre and thyroid nodule, and to analyse the associations among age, gender, anthropometrics and thyroid volume in school children.Materials and method: Schools governed by Ministry of Education in Van province were included into the study. Sonographic evaluations of thyroid glands were performed in children aged 6–17 years, and weight, height, waist circumference, hip circumference, and skinfold thickness...

Purpose: The aimof this study is to investigate the presence of microalbuminuria in children and adolescents diagnosed with Graves' Disease (GD) and Hashimoto's thyroiditis (HT) and compare the results with the healthy control group.Materials and Methods: This cross-sectional, single-center study included 35 patients with GH, 29 patients with HT, and 34 healthy control groups. Microalbumin and creatinine measur...

Introduction: The impact of COVID-19 on the thyroid axis is still unclear. The most recent studies have presented contradictory findings. Theoretically, both direct toxic effects and indirect inflammatory responses can influence thyroid functions. A limited number of studies conducted in pediatric patients have revealed cases of hypothyroidism, hyperthyroidism, and nonthyroidal illness syndrome occurring during the COVID-19 infection.<st...

Purpose: Therapeutic goals in the adolescent male with hypogonadotropic hypogonadism(HH) are virilization, optimal adult height, normal bone mass, body composition, psychosocial development, and fertility. Until recently, only testosterone was used to treat adolescent males with HH. However, this treatment did not cover all treatment goals and adverse effects on fertility were reported. Therefore, gonadotropin therapy can be used in addition to testosterone in...

Background: Hypergonadotropic hypogonadism(HH) in females results from primary gonadal failure related to genetic defects affecting ovarian development and function or acquired gonadal damage; limited knowledge exist regarding underlying genes involved or potential gene X environment interactions responsible for disease trait manifestations. While pathogenic variants in single genes, chromosomal abnormalities such as Turner syndrome and acquired gonadal damage...

Background: Vitamin D, mainly important in calcium phosphate homeostasis and bone health, has been recently suggested as an important factor in pathogenesis of numerous chronic conditions such as type 2 diabetes, metabolic syndrome and polycystic ovarian syndrome (PCOS).Objective and hypotheses: The aim of this study is to investigate the relation between PCOS and premature adrenarche (PA), suggested as predictor of PCOS.Method: A ...

Background: Recently, T3 receptor alpha (TRα) mutations have been identified in a number of patients with varying degrees of growth impairment, delayed development, constipation, increases in serum T3 and decreases in T4 and rT3.Objective: To determine the spectrum of clinical and functional consequences of novel TRα mutations.Method: Clinical assessment and biochemical, imaging...