hrp0098p1-219 | Bone, Growth Plate and Mineral Metabolism 3 | ESPE2024

Prospective longitudinal assessment of bone mineral density, circulating markers of bone turnover and changes in body composition in children and adolescents treated for acute lymphoblastic leukemia

Molinari Silvia , Laura Nicolosi Maria , Capitoli Giulia , Tondelli Daniele , Corbetta Sabrina , Vai Silvia , Radaelli Silvia , Biondi Andrea , Adriana Cristina Balduzzi , Sala Alessandra , Cattoni Alessandro

Background: Acute lymphoblastic leukemia (ALL) is the most frequently reported cancer in paediatrics. Reduced bone mineral density (BMD) and increased risk of fractures have been well-documented in this population, but long-term longitudinal trendlines of BMD and data about the impact of bone turnover markers are still scarce. Additionally, changes in body composition have to be furtherly analysed among childhood ALL survivors.St...

hrp0098p1-176 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

Pelvic ultrasound and pubertal attainment in girls with sexual precocity: the pivotal role of uterine volume in predicting the timing of menarche

Cattoni Alessandro , Russo Gianni , Capitoli Giulia , Rodari Giulia , Laura Nicolosi Maria , Molinari Silvia , Tondelli Daniele , Pelliccia Ciretta , Radaelli Silvia , Arosio Andrea , Fondata Katia , Tattesi Giulia , Passoni Paolo , Boneschi Annalisa , Giavoli Claudi , Laura Carla Meroni Silvia , Rita Stancampiano Marianna , Garuti Elda , Biondi Andrea , Balduzzi Adriana , Bizzarri Carla

Introduction: Among girls assessed for pubertal precocity, pelvic ultrasound (pUS) may represent a pivotal tool to predict the time expected to elapse between sonographic assessment and the onset of menarche (TUS-M). Accordingly, the present analysis is meant to define the statistical relationship between sonographic parameters and TUS-M, in order to identify the most reliable predictor of the timing of menarche.<st...

hrp0084p3-971 | GH &amp; IGF | ESPE2015

Patients with Childhood Onset Growth Hormone Deficiency Treated with rhGH – Reevaluation in the Transition Period between Childhood and Adulthood – Preliminary Study

Procopiuc Camelia , Caragheorgheopol Andra , Gherlan Iuliana , Brehar Andreea , Padure Adriana , Dumitrascu Andra , Costache Mariana , Ardeleanu Ioana , Dumitrescu Crisina

Background: More than two thirds of teenagers with childhood-onset GH deficiency (CO-GHD) documented normal GH response when retested at final height.Objective and hypotheses: To identify potential predictors for persistent GHD after reaching final height under rhGH with a particular accent on children with isolated GHD (IGHD).Method: Prospective study: reevaluation CO-GHD in the transition period; cohort of 27 CO-GHD patient who r...

hrp0084p3-1018 | Growth | ESPE2015

Vitamin D in Short Children on GH Therapy: Effects of Vitamin D Status and Vitamin D Supplementation on Glucose Homeostasis

Dumitrescu Cristina , Caragheorgheopol Andra , Gherlan Iuliana , Brehar Andreea , Padure Adriana , Olaru Maria , Procopiuc Camelia

Background: Glucose metabolism effects of vitamin D deficiency are debated. GH therapy is associated with increased insulin values and decreased insulin sensitivity.Objective and hypotheses: To investigate vitamin D status in short children treated with GH- to investigate if the known effects of GH therapy on glucose metabolism are modulated by vitamin D supplementation.Method: 41 children treated with GH for short stature where ev...

hrp0084p3-1172 | Thyroid | ESPE2015

Central Hypothyroidism and GH Deficiency in a Boy with Williams–Beuren Syndrome

Ciccone Sara , Fumarola Adriana , Bigoni Stefania , Bonifacci Valentina , Marrella Elisa Maria Gabriella , Buldrini Barbara , Host Cristina

Background: Thyroid disorders (subclinical hypothyroidism and structural abnormalities) are common in Williams syndrome (WS) patients.Objective and hypotheses: Central hypothyroidism and GH deficiency (GHD) in a WS patient are discussed.Method: Case report and literature review.Results: A 5-month-old male was admitted to our hospital because of growth failure since the 3rd month, mild dysmorphisms, micropenis...

hrp0095lb12 | Late Breaking | ESPE2022

Sleep Quality in Caregivers of Type 1 Diabetes Mellitus Pediatric Patients - The Impact of isCGM Alarms

Sousa Eulália , Luís Telma , Cristina Santos Ana , Lima Conceição , Adriana Rangel Maria , Arménia Campos Rosa , Luísa Leite Ana

Background: Type 1 diabetes mellitus (T1DM) is one of the most frequent chronic diseases in the pediatric age and demands constant and rigorous glycemic control. Intermittently scanned continuous glucose monitoring (isCGM) systems are a helpful tool in diabetes management. Second-generation isCGM contain alarms to assist in the detection of hyper or hypoglycemia. We aimed to compare the sleep quality of principal caregivers of T1DM pediatric patients who use i...

hrp0082p3-d3-796 | Fat Metabolism &amp; Obesity (2) | ESPE2014

Prevalence of Overweight and Obesity in Children and Adolescents at Public and Private Schools from Uberaba Brazil

Silva Adriana Paula , Feibelmann Taciana Carla Maia , Silva Daniela Cristina , Palhares Heloisa Marcelina Cunha , Scatena Lucia Marina , Borges Maria de Fatima

Background: In Brazil there is a nutritional transition between child malnutrition and increasing prevalence of obesity.Objective and hypotheses: The study aims to identify the prevalence of overweight and obesity in children aged 5–18 years in five private and 15 public schools from city of Uberaba Brazil.Method: Anthropometric data, inventorys physical activities and socioeconomic aspects were evaluated from 1125 individuals...

hrp0082p3-d1-925 | Puberty and Neuroendocrinology | ESPE2014

The Timing and Evolution of Puberty in a Sample of School-Aged Children in a Brazilian City

Feibelmann Taciana Carla Maia , da Silva Adriana Paula , Silva Daniela Cristina , de Resende Elisabete Aparecida Mantovani Rodrigues , Scatena Lucia Marina , de Fatima Borges Maria

Background: The beginning and evolution of physiological puberty may be occurring earlier, resulting in change in the age at which clinical investigation on precocious puberty must be conducted, as well as concerns regarding the possible deleterious effects of hormone exposure in a later stage of life.Objective and hypotheses: Assess age of beginning and evolution of puberty in boys and girls acknowledging the age of thelarche (T), menarche (M), period b...

hrp0089p2-p408 | Thyroid P2 | ESPE2018

The Congenital Hypothyroidism Screening Programme in a Sigle Italian Centre: a 5-Years Retrospective Study

Maggio Maria Cristina , Ragusa Saveria Sabrina , Aronica Tommaso Silvano , Granata Orazia Maria , Gucciardino Eleonora , Corsello Giovanni

Congenital hypothyroidism (CH) occurs in approximately 1:2000–1:3000 newborns in Italy. Lowering of the TSH cut-off was the most important factor contributing to the increase of CH incidence in Italy. The aim of this study is the determination of the prevalence of CH in northwest Sicily, evaluated by the single screening centre of the Children Hospital ‘G. Di Cristina’, ARNAS, Palermo. From January 2013 to December 2017, 79.699 newborns were screened testing TSH...

hrp0082p1-d3-53 | Bone (1) | ESPE2014

Bone Mineral Density Evaluation in Children with Gaucher Disease

Larroude Maria Silvia , Drelichman Guillermo , Cassinelli Hamilton , Richard Lucia , Ruiz Alba , Reicher Paola , Cuello Fernanda , Lanza Victoria , Fernandez Ramiro , Maro Alejandra , Corrales Marcela , Arizo Adriana , Escobar Nicolas Fernandez , Rapetti Cristina , Donato Hugo , Chain Juan Jose , Zirone Sandra , Cedola Alejandra , Bietti Julieta , Sweri Maia

Background: Bone involvement is described as a relevant sign in patients suffering Gaucher disease (GD).Objective and hypotheses: To analyze the long-term effect of enzyme replacement therapy on bone mineral density, a retrospective observational study was conducted in a cohort of 34 GD pediatric patients (14 males, 20 females, median age 11.3 years).Method: Lumbar spine (LS) (L2–L4, N: 34) and total body (TB) (N: 24) bone min...