ESPE Abstracts

Background: Diabetic neuropathic cachexia is a rare syndrome of acute neuropathic pain and profound weight loss. Mauriac syndrome has rarely been reported in children and adolescents with a poorly controlled diabetes mellitus type 1. Common presenting features include short stature, growth retardation, moon facies, protuberant abdomen, and proximal muscle wasting. We report the first case of the association of Mauriac Syndrome and Diabetic neuropathic cachexia...

Introduction: The selection of insulin therapy for children with type 1 diabetes (T1DM) poses a challenge, particularly in low- and middle-income countries. This study aimed to assess the utilization of insulin analogues in diabetic children and identify factors associated with achieving glycemic goals.Methods: In a retrospective study involving 80 children with T1DM, the impact of transitioning from human insulin to ins...

Introduction: McCune Albright syndrome (MAS) is classically defined by the clinical triad: fibrous dysplasia of bone, café-au-lait skin pigmentation and endocrinopathies :The most frequent is precocious puberty. Linked to a somatic mutation of the α subunit of the Gs protein, this syndrome leads to a constitutive activation of adenylate cyclase, to the excessive production of AMPcCase presentation: Here we r...

Introduction: Ketoacidosis is often indicative of diabetes in children in our Tunisian context. It can be severe and life-threatening, with mortality in the order of 1 to 2%.Methods: We report the results of a retrospective study over a period of 2 years (from 1/01/2017 to 31/12/2018) on all cases of inaugural ketoacidosis of type 1 diabetes mellitus in children, collected at the pediatric department of Mohamed Tlatl...

Background: Prior research has shown a correlation between TSH levels and BMI in euthyroid subjects. Whether this relation can be applied to hypothyroid chemically euthyroid children has yet to be determined.Objective and hypotheses: To determine if there is a correlation between TSH levels and BMI percentiles in hypothyroid children who are chemically euthyroid on levothyroxine.Method: Retrospective chart review of patients from R...

Introduction: Diabetes is a global disease with approximately 425 millions of people affected throughout the world. The treatment cost for diabetes constitutes a significant economic burden and is estimated to increase in areas of Africa, South East Asia and the middle east in parallel to the increase to the disease incidence. These regions contribute differently in the global market revenue for the use of continuous glucose monitoring (CGM) and insulin pump t...

Introduction: X Linked hypoposphatemic rickets (XLH) is a rare genetic disorder characterized by variable clinical features. It is often misdiagnosed with other types of rickets. A novel effective treatment is currently available. We report four cases of XLH who presented to our centre over a period of five years and describe their clinical presentation, diagnostic, treatment challenge and outcome.CASE 1 -The child presented with short s...

Introduction:Despite the widely proven value of insulin analogs in the treatment of children with type 1 diabetes (T1D), pediatric studies of Increased weight gain in T1D are complicated by the age-dependency and gender-dependency of BMI, and also by a trend towards obesity in the general population.Objective: to assess the impact of switching from Humain Insulin (HI) to insulin analogues on the BMI of children with T1D....

Amenorrhea constitutes one of the primary reasons for consultation in reproductive medicine. Amenorrhea in adolescents can be either primary or secondary.Clinical Observation: She is a 16-year-old girl, born of a second-degree consanguineous marriage, the eldest of 2living siblings, She presents with primary amenorrhea. A aunt, aged 40, also presents with the same unexplored issue. The illness history dates back a year following primary ...

Background: Hereditary hypomagnesemia with secondary hypocalcemia (HSH) is a are autosomal recessive disorder which presents in early infancy with generalized convulsions, or other symptoms related to increased neuromuscular excitability. Several mutations in the TRPM6 gene have been described. Early diagnosis is an effective means of preventing the inevitable neurocognitive sequelae which occur in the absence of appropriate treatment.<s...