hrp0084p3-758 | Diabetes | ESPE2015

A Case of Tacrolimus Related Posttranslated Diabetes Mellitus (PTDM)

Keskin Mehmet , Karaoglan Murat , Kara Mehtap Akbalik , Buyukcelik Mithat , Keskin Ozlem

Background: Tacrolimus is highly potent immunosuppressant agent. Despite it is quite prophylactic effect on renal allogreft rejection, the most marked side effect of tacrolimus is lead to posttranslated diabetes mellitus. There are some predictive risk factors which are determined on development of tacrolimus related diabetes mellitus: Advanced age, familial history, genetic factors, ethnicity, impaired glucose tolerance or metabolic syndrome in pre-transplantation period, obe...

hrp0084p3-1042 | Growth | ESPE2015

GH Treatment in Survivors of Paediatric Brain Tumors

Darcan Sukran , Ozcan Nurhan , Goksen Damla , Kantar Mehmet , Turhan Tuncer , Cetingul Nazan , Ozen Samim

Background: Survival from brain tumors is increasing in children and these patients will likely have severely GH deficiency.Objective and hypotheses: To evaluate the effect of GH treatment (GHT) in children treated for brain tumor successfully.Method: Thirteen patients who received GHT after brain tumor treatment were evaluated retrospectively. Height SDS, annual growth rate SDS, height gain, and serum IGF1 levels were collected at...

hrp0094p2-422 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

17-hydroxylase deficiency and diabetes in a case with 46 XY female

Yildirim Ahmet , Zeytun Hikmet , Albayrak Serpil , Karaoğlan Murat , Keskin Mehmet

A 13-year-old patient was admitted due to delayed puberty. Ovary and uterus had not seen in USG and MRI. On physical examination; body weight: 57 kg (79 P), height 157.7 cm (45P), BMI: 22.9 (83P), TA: 120/80 mmHg. The patient was externally in female appearance and there was no puberty development. Labia minora was seen. The urethral and vaginal openings were in the vestibulum and bilateral gonads could not be palpated in the inguinal canal. Mother and father was cousin. Fathe...

hrp0094p2-432 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

46,XY DSD due to biallelic DHX37 gene mutations

Eltan Mehmet , Helvacioglu Didem , Ates Esra Arslan , Abali Zehra Yavas , Turan Serap , Bereket Abdullah , Guran Tulay

Background: DEAH-box protein DHX37, encodes an RNA helicase, is involved in ribosome biogenesis. Monoallelic mutations in DHX37 gene have recently been identified in 46,XY differences/disorders of sex development (DSD) patients with nonsyndromic gonadal dysgenesis as well as testicular regression, while biallelic mutations have been associated with microcephaly and structural brain abnormalities. Here, we present a patient with penoscrotal hypospadias and bil...

hrp0094p2-65 | Bone, growth plate and mineral metabolism | ESPE2021

Is conventional treatment still the first choice in pediatric patients with PHEX mutations in an era of monoclonal FGF-23 antibody?

Alikasifoglu Ayfer , Unsal Yagmur , Gonc Nazlı , Ozon Alev , Kandemir Nurgun , Alikasifoglu Mehmet ,

Objective: Hereditary hypophosphatemic rickets is a rare renal phosphate wasting disorder causing burden on pediatric patients despite conventional treatment of phosphate and calcitriol. The aim of this study is to analyze genetic and clinical variability of children with X-linked hypophosphatemic rickets (XLHR), focusing on short term, long term and pubertal impact of conventional treatment. Design: Retrospective cohort studyMet...

hrp0094p2-114 | Diabetes and insulin | ESPE2021

Evaluation of serum myostatin levels in patients with insulin dependent diabetes mellitus

Burak Selver Muhammed , Emre Atabek Mehmet , Selver Eklioglu Beray , Kurban Sevil ,

Objective: We aimed to evaluate the relationship between serum myostatin levels and metabolic parameters in children with insulin dependent (Type 1) diabetes mellitus and to show the relationship with sarcopenia in children with insulin dependent diabetes mellitus.Methods: Forty -four patients aged between 8 and 16 years, and 45 control patients were enrolled in the study. Anthropometric measurements and laboratory analy...

hrp0094p2-144 | Diabetes and insulin | ESPE2021

Is Type 1 Diabetes Mellitus Predictable? Investigation of Predictive Markers n Siblings of Probands with Newly Diagnosed Type 1 Diabetes Mellitus

Albayrak Serpil , Karaoglan Murat , Yıldırım Ahmet , Keskin Mehmet ,

Background/Aim: Type 1 diabetes Mellitus (T1DM) often presents with clear clinical signs after a long-term asymptomatic autoimmune process. This long and silent period has been leading to an increase in awareness day by day in order to prevent and predict the development of the disease. Among the well-known genetic and environmental risk factors, close relatives of the index cases constitute a population that is quite suitable for predicting and preventing the...

hrp0094p2-254 | Growth hormone and IGFs | ESPE2021

Clinic, laboratory and prognostic findings of patients who are diagnosed by Kowarski syndrome (biologically inactive growth hormone)

Gokcehan Zevker Emine , Keskin Mehmet , Karaoglan Murat , Aytac Kaplan Emel H ,

Objective: The clinical, laboratory and prognostic findings of the patients diagnosed with Kowarski Syndrome (biologically inactive growth hormone) were evaluated between February 2009 and February 2019 in order to contribute to literature.Materals and Methods: 110 cases diagnosed with Kowarski syndrome between February 2009 and February 2019 were evaluated retrospectively. 97 cases continued to work. 92 cases at least one year, 62 cases...

hrp0097fc13.4 | Pituitary, neuroendocrinology and puberty 2 | ESPE2023

Clinical and molecular genetic characteristics of 98 patients with congenital hypopituitarism: A single-center experience

Yavas Abali Zehra , Arslan Ates Esra , Eltan Mehmet , Turan Serap , Bereket Abdullah , Guran Tulay

Background: Congenital hypopituitarism (CH) refers to a deficiency of one or more pituitary hormones resulting from variants in genes encoding transcription factors for pituitary development. CH cases are mostly sporadic but 5-30% can be familial. Genetic etiology is not determined in most cases. The aim of our study was to evaluate the genetic features of CH using different molecular and/or molecular cytogenetic techniques.Subje...

hrp0097p2-134 | Fat, Metabolism and Obesity | ESPE2023

Short-term data of the newly opened pediatric obesity center in Ankara

Kocaay Pınar , Adıgüzel Kezban , Tepe Derya , Boyraz Mehmet

Childhood obesity has emerged as an important public health problem in the worldwide. It is important to follow these cases in multidisciplinary centers at an early age in order to prevent metabolic and psychosocial comorbidities that may develop. Bariatric surgery is a treatment method whose frequency is increasing in adolescent obesity. In the study, the 6-month results of the patients who applied to the obesity center were shared.Materials-Met...