hrp0098fc12.3 | Thyroid | ESPE2024

Usefulness of application novel TurboTM TSAb bioassay in the monitoring of pediatric Graves’ patients

Bossowski Artur , Sawicka Beata , Borysewicz-Sańczyk Hanna , Bossowski Filip , Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 95-99% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in a patient with Hashimoto’s thyroiditis (HT) using a novel and ultra-rapid TSAb bioassay.<...

hrp0098p1-34 | Diabetes and Insulin 2 | ESPE2024

SEXUAL KNOWLEDGE AND CONTRACEPTIVE USE IN ADOLESCENTS WITH TYPE 1 DIABETES IN COMPARISON WITH THEIR HEALTHY PEERS

Paltoglou George , Kandyla Betina , Tsitsika Artemis , Tzavara Chara , Soldatou Alexandra , Karanasios Spyridon , Kossiva Lydia , Karavanaki Kyriaki

Introduction: Adolescents with type 1 diabetes mellitus (T1D) may differ from their healthy peers in respect to sexually transmitted diseases (STDs) knowledge and contraceptive use.Objectives: We aimed to explore sexual knowledge and contraceptive use and associated factors in T1D adolescents compared to healthy peers.Methods: Fifty-eight T1D adolescents (mean&pm;SD age 16.3&pm;2.0...

hrp0098p1-133 | Fat, Metabolism and Obesity 2 | ESPE2024

The effect of a lifestyle intervention program of diet, sleep and exercise on apelin-12, vaspin and resistin concentrations in children and adolescents with overweight and obesity

Karampatsou Sofia-Iliada , Paltoglou George , Genistaridi Sofia-Maria , Kassari Penio , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents one of the most challenging public health problems of the 21st century owing to its epidemic proportions worldwide.Aim: The aim of our study was to determine the concentrations of apelin-12, vaspin and resistin in children and adolescents with overweight and obesity before and 1 year after the implementation of a lifestyle intervention program of diet, sleep and...

hrp0098p2-81 | Diabetes and Insulin | ESPE2024

“Sweet” lies detector; Factitious Diabetes Mellitus as a rare presentation of Munchausen by Proxy syndrome

Paltoglou George , Koutrouli Mina , Panos Alexandros , Plarinou Adamantini , Siori Dimitra , Tzavela Eleni , Soldatou Alexandra , Karavanaki Kyriaki

Background/Purpose: Case report of two siblings (nine-year-old boy and four-year-old girl) with rarely described factitious diabetes by proxy, aim ing to enhance physician’s awareness.Methods: Initially the boy was referred by a physician to the outpatient clinic to apply (successfully) for an insulin pump. The mother convincingly claim ed her son has had T1DM for 3 years. Reported history started during hospitaliz...

hrp0089rfc5.5 | Thyroid | ESPE2018

Evidence for a Founder Effect in Multiple Endocrine Neoplasia 2

Fanis Pavlos , Skordis Nicos , Frangos Savvas , Christopoulos George , Spanou-Aristidou Elena , Andreou Elena , Manoli Panayiotis , Mavrommatis Michalis , Nicolaou Stella , Kleanthous Marina , Cariolou Marios A , Christophidou-Anastasiadou Violetta , Tanteles George A , Phylactou Leonidas A , Neocleous Vassos

Purpose: Multiple Endocrine Neoplasia type 2 (MEN2) affects patients with RET proto-oncogene mutations. This cohort study refer to patients who were diagnosed with familial medullary thyroid carcinoma (MTC) and underwent RET genetic testing in Cyprus between years 2002 and 2017.Methods and Patients: Forty patients underwent RET testing by Sanger sequencing of exons 10–11 and 13–16. Genotyping with STR genetic markers ...

hrp0089rfc6.5 | Fat, Metabolism and Obesity | ESPE2018

High-Throughput Untargeted Plasma Metabolomics Unravels Gender Dimorphic Metabolic Trajectories in Naturally Conceived and ICSI Prepubertal Children

Telonis Aristeidis G , Gkourogianni Alexandra , Papassotiriou Ioannis , Konsta Maria , Papastamataki Maria , Margeli Alexandra , Bartzeliotou Anastasia , Mantzou Emilia , Kosteria Ioanna , Mastorakos George , Loutradis Dimitrios , Chrousos George P , Klapa Maria I , Kanaka-Gantenbein Christina

Background: Accumulating evidence has indicated that assisted reproductive technologies (ART) influence the metabolic physiology of the offspring, with a higher predisposition to metabolic disorders. Long-term metabolomic studies that separately consider males and females conceived with intra-cytoplasmic sperm injection (ICSI) vs naturally conceived (NC) children are needed. Previously, we had reported that ICSI-conceived prepubertal girls exhibit significant alterations in th...

hrp0092p1-148 | Thyroid | ESPE2019

Activating mutation M453V in receptor TSHR as a cause familial hyperthyroidism

Sawicka Beata , Stephenson Alexandra , Borysewicz- Sanczyk Hanna , Michalak Justyna , Stozek Karolina , Tanja Diana , Kahaly George , Paschke Ralf , Bossowski Artur

The most common hyperthyroidism in children is Graves' disease. The other rare cause of hyperthyroidism is activating mutation in receptor TSHR in thyroid gland.We would like to introduce a case of familial hyperthyroidism with a novel mutation M453V in the TSHR in three membersActually 11-year-old boy is a patient in outpatient clinic for first days after birth. During gestation his mother was treated with thyreostatic drugs b...

hrp0092p1-334 | Fat, Metabolism and Obesity (2) | ESPE2019

ADCY3 Genetic Variants in Cypriot Obese Children

Frixou Maria , Fanis Pavlos , Skordis Nicos , Stylianou Charilaos , Tanteles George A , Toumba Meropi , Neocleous Vassos , Phylactou Leonidas A , Pantelidou Maria

Background: The adenylate cyclase 3 (ADCY3) gene encodes a membrane-associated protein involved in the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This gene seems to be is involved in the regulation of several metabolic processes and has been recently associated to pathophysiological metabolic conditions. Several ADCY3 variants have been linked with obesity in children.M...

hrp0089fc1.5 | Adrenals &amp; HPA Axis | ESPE2018

Untargeted Plasma Metabolomics in Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies a Novel metabolic Signature

Nicolaides Nicolas C. , Ioannidi Maria-Konstantina , Koniari Eleni , Sertedaki Amalia , Klapa Maria I. , Chrousos George P. , Charmandari Evangelia

Background: Tissue glucocorticoid sensitivity is characterized by a considerable variation in terms of therapeutic response and side effects to synthetic glucocorticoids. The multi-metabolite concentration profile measured by untargeted plasma metabolomics provides a comprehensive metabolic signature that might be used in clinical practice.Objective and Hypotheses: To investigate the usefulness of plasma metabolomics in identifying a metabolic signature ...

hrp0089p1-p023 | Adrenals and HPA Axis P1 | ESPE2018

Associations Between Maternal and Offspring Hair Cortisol Concentrations and Child Behavioral Symptoms in Pairs of Children 18–48 Months Old and their Mothers With and Without Perinatal Mental Disorders

Agapaki Anna , Papagianni Fenia , Valavani Eleni , Zervas Ioannis , Mantziou Aimilia , Kanelli Stamatina , Spyropoulou Areti , Chrousos George , Pervanidou Panagiota

Introduction: Maternal perinatal mental disorders (PMDs) are associated with developmental and behavioral problems in the offspring, probably mediated by the programming of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. Increased or decreased cortisol concentrations during pregnancy and the perinatal period have been associated with alterations in the stress responses of the offspring and with child behavioral problems; however, such associations remain unclear.<p ...