hrp0082p1-d2-28 | Autoimmune Endocrine Disease | ESPE2014

Immune Changes are Observed After Radioiodine Treatment for Hyperthyroidism in Graves’ Disease Patients

Cote-Bigras Sarah , Verreault Jean , Rottembourg Diane

Background: Graves’ disease (GD) involves autoimmunity against TSH receptor (TSHR) bearing cells, leading to hyperthyroidism and often orbitopathy. When hyperthyroidism is treated with radioactive iodine (RAI), exacerbation of the orbital disease can occur.Objective and hypotheses: We hypothesized that RAI has immune effects affecting the balance between auto-reactive T cells and T cells with regulatory properties.Method: We m...

hrp0082p2-d3-503 | Perinatal and Neonatal Endocrinology | ESPE2014

Survey of Opinion on the Antenatal and Surgical Management of Disorders of Sex Development and Congenital Adrenal Hyperplasia

White Mary , Hewitt Jacqueline

Background: Congenital adrenal hyperplasia (CAH) is characterised by elevated adrenal androgens which can lead to virilisation of affected females.Objective and hypotheses: To outline clinical opinion on two controversial aspects of CAH management (antenatal dexamethasone and genital surgery of affected females) which was hypothesised would differ between regional centres.Methods: A survey was conducted via the Aus...

hrp0082p3-d2-645 | Adrenals & HP Axis (1) | ESPE2014

Untreated Congenital Hyperplasia with Central Precocious Puberty

Dimitrova Mihaela , Stefanova Elisaveta , Kazakova Krasimira , Yordanova Desislava , Todorova Zdravka

Background: Congenital adrenal hyperplasia (CAH) may cause early maturation of hypothalamic–pituitary–gonadal axis when the initiation of corticosteroid treatment is late or/and there is poor compliance. The latter sometimes leads to a lack of treatment. In most cases, if the child survives, he or she develops central precocious puberty.Case report: We present a 12-year-old boy born of a normal pregnancy and delivery. In the first months of lif...

hrp0098rfc12.6 | Thyroid | ESPE2024

Evaluation of thyroid nodules in children and adolescents by shear wave elastography (SWE)

Borysewicz-Sańczyk Hanna , Bossowski Filip , Anikiej Katarzyna , Sawicka Beata , Michalak Justyna , Dzięcioł Janusz , Bossowski Artur

Background: Shear wave elastography (SWE) is an ultrasound diagnostic method evaluating tissue’s stiffness. It has been demonstrated that the mechanical properties of tissue involved in the pathological process are changed and SWE might indicate regions of the examined tissue covered by the disease. In adults SWE is used to differentiate benign and malignant nodules in thyroid gland, however there are still few studies on application of SWE in thyroid di...

hrp0098p1-100 | Thyroid 1 | ESPE2024

Evaluating Malignancy in Pediatric Thyroid Nodules: The Effectiveness of the Bethesda System and TIRADS

Gazek Natalia , Suarez Mozo Melissa , Celeste Mattone Maria , Santana Olivares Jesus , Ciaccio Marta , Dujovne Noelia

Introduction: The risk of malignancy of pediatric thyroid nodules is determined according to the Bethesda System. Biopsy is performed by fine needle aspiration (FNA) based on ultrasonography (US) patterns. To identify suspicious nodules in adults, the Thyroid Imaging Reporting and Data System (TI-RADS) is widely used; however, its use in pediatrics is less common.Aim: To analyze the usefulness of the Bethesda system and ...

hrp0098p2-76 | Diabetes and Insulin | ESPE2024

Severe hypertriglyceridemia: a rare but serious complication of diabetic ketoacidosis in children

Ould Mohand Ouamer , Allali Kawthar , Mekki Azzedine

Introduction: Ketoacidosis is an acute metabolic complication often indicative of diabetes in children. It can be severe and life-threatening, especially when complicated by major hypertriglyceridemia (HTg). This association is rare in pediatrics but should not be overlooked.Observation: A 8-year-old girl admitted for treatment of severe diabetic ketoacidosis (DKA). The biological assessment, apart from the diagnostic cr...

hrp0098p3-286 | Late Breaking | ESPE2024

Severe hypertriglyceridemia: A rare but serious complication of diabetic ketoacidosis in children

Ould Mohand Ouamer , Zeroual Zoulikha , Mekki Azzedine

Introduction: Ketoacidosis is an acute metabolic complication often indicative of diabetes in children. It can be severe and life-threatening, especially when complicated by major hypertriglyceridemia (HTg). This association is rare in pediatrics but should not be overlooked.Observation: A 8-year-old girl admitted for treatment of severe diabetic ketoacidosis (DKA). The biological assessment, apart from the diagnostic cr...

hrp0094p1-8 | Adrenal A | ESPE2021

Long-term Cardiometabolic Morbidity In Young Adults With Classic 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia

Righi Beatrice , Ali Salma R , Bryce Jillian , Tomlinson Jeremy W , Bonfig Walter , Baronio Federico , Costa Eduardo C , Filho Guilherme Guaragna , T’Sjoen Guy , Cools Martine , Markosyan Renata , Bachega Tania A S S , Miranda Mirela C , Iotova Violeta , Falhammar Henrik , Ceccato Filippo , Stancampiano Marianna R , Russo Gianni , Vukovic Rade , Giordano Roberta , Mazen Inas , Guven Ayla , Darendeliler Feyza , Poyrazoglu Cukran , Vries Liat de , Ellaithi Mona , Daniel Eleni , Johnston Colin , Hunter Steven J , Carroll Paul V , Adam Safwaan , Perry Colin G , Kearney Tara , Abraham Prakash , Rees D Aled , Leese Graham P , Reisch Nicole , Stikkelbroeck Nike M M L , Auchus Richard J , Ross Richard J , Ahmed S Faisal ,

Background: Congenital adrenal hyperplasia (CAH) and long-term glucocorticoid treatment may be associated with an increased risk of developing cardiometabolic sequelae such as abnormal glucose homeostasis, hyperlipidaemia, hypertension, cardiovascular (CV) disease, obesity and osteoporosis.Objectives: To study the current practice amongst expert centres for assessing cardiometabolic outcomes in adult patients with 21-hyd...

hrp0092p1-333 | Diabetes and Insulin (2) | ESPE2019

Abdominal Fat Distribution Assessed by Abdominal CT Scan in Adolescents with Type 2 Diabetes Mellitus

Abe Yuriko , Urakami Tatsuhiko , Hara Mitsuhiko , Yoshida Kei , Mine Yusuke , Aoki Masako , Suzuki Junichi , Saito Emiko , Iwata Fujihiko , Okada Tomoo , Morioka Ichiro

Background: Abdominal fat distributions are reportedly strongly associated with metabolic risks in type 2 diabetes mellitus. However, research on fat distribution in adolescents with type 2 diabetes mellitus has been limited.Aim: To investigate fat distribution characteristics in adolescents with type 2 diabetes mellitus for comparison to those with simple obesity in Japan.Design/Methods</s...

hrp0098rfc2.1 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Bone and Body Composition after one year of Vosorotide treatment in children with Achondroplasia: a longitudinal prospective study.

Angelelli Alessia , Elsa Maria Allegri Anna , Tedesco Caterina , Maiorano Nadia , Zucconi Alice , Repetto Agnese , Gizzi Gilda , Napoli Flavia , Casalini Emilio , Fava Daniela , Mohamad Maghnie , Di Iorgi Natascia

Background: Bone and body composition data in Achondroplasia (Ach) treated or not with vosorotide are lacking.Aim: To assess longitudinally body composition and bone markers in children with Ach during Vosorotide treatment (V-Tx).Method: Twenty-one patients (F=11, M=10) underwent DXA evaluation before (T0) and after 12 months of V-Tx (T12): bone mineral density-BMD (g/cm2</sup...